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Pharmaceutical composition for treating cerebral arterial thrombosis and application thereof

A technology for ischemic stroke and a composition, applied in the field of medicine, can solve the problems of insufficient drugs, many adverse reactions, poor curative effect, etc. effects of stroke

Active Publication Date: 2020-04-14
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a pharmaceutical composition composed of Codonopsis total saponins, Ligusticolide I and Borneol in order to solve the problems of insufficient drugs, poor curative effect and many adverse reactions in the current effective treatment of ischemic stroke. , the pharmaceutical composition has the advantages of few components, small dosage, good effect and no side effects

Method used

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  • Pharmaceutical composition for treating cerebral arterial thrombosis and application thereof
  • Pharmaceutical composition for treating cerebral arterial thrombosis and application thereof
  • Pharmaceutical composition for treating cerebral arterial thrombosis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The sources of the components are as follows.

[0033] The preparation method of the total saponins of Codonopsis Codonopsis: Codonopsis Codonopsis medicinal material is crushed, passed through a 40-mesh sieve, added ethanol with a volume fraction of 70% (according to 1g of powder to add 30mL ratio), soaked for 24h, ultrasonicated at 40°C for 30min, suction filtered, and the filtrate was decompressed to recover the solvent to obtain Codonopsis total saponins extract. The yield of total saponins of Codonopsis pilosula was 1.522%.

[0034] Ligusticolide I reference substance was purchased from Chengdu Croma Biotechnology Co., Ltd., batch number 140827. Borneol was purchased from Beijing Tongrentang Pharmacy, produced by Beijing Sanhe Pharmaceutical Co., Ltd., batch number 77820501.

Embodiment 2

[0036] Preparation of a pharmaceutical composition for treating ischemic cerebral apoplexy: take 4 parts of Codonopsis total saponins, 5 parts of Ligusticolactone I and 11 parts of Borneol. After mixing with 1.5 parts of starch, sieve and dry, add 0.1 part of magnesium stearate and 0.1 part of talcum powder, and press into tablets.

Embodiment 3

[0038] Preparation of a pharmaceutical composition for treating ischemic cerebral apoplexy: 5 parts of Codonopsis total saponins, 6 parts of Ligusticolactone I and 12 parts of Borneol are weighed. After mixing with 1.7 parts of starch, sieve and dry, then add 0.11 parts of magnesium stearate and 0.11 parts of talcum powder, and tablet it.

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Abstract

Being applicable to the technical field of medicine, the invention provides a pharmaceutical composition for treating cerebral arterial thrombosis related diseases. The pharmaceutical composition comprises: 3-7 parts of total saponins of codonopsis pilosula, 4-8 parts of senkyunolide I and 10-15 parts of borneol. The pharmaceutical composition provided by the invention is simple in formula, economical and practical, complementary, and reasonable in compatibility, and can effectively treat cerebral arterial thrombosis. Moreover, the components are all from natural products, and no adverse reaction, toxic or side effect is generated after long-term use, therefore the pharmaceutical composition is worthy of popularization and application. According to the preparation method of the pharmaceutical composition provided by the invention, the components in the formula ratio are uniformly mixed and then are mixed with pharmaceutically acceptable auxiliary materials so as to obtain the pharmaceutical preparation. The method is simple, convenient to operate, and is suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating ischemic stroke and its application. Background technique [0002] Stroke is one of the three major diseases that endanger human health and life, second only to heart disease and tumors, and its mortality rate has reached 21.3% in our country. Among them, ischemic stroke is the most common type of stroke (about 69.6%). With the aging population and the increase in the number of hypertensive patients in my country, reducing the morbidity, mortality and disability of ischemic stroke has become an urgent and important task. The current Western medicine treatment of stroke mainly uses nifedipine, aspirin, tissue prothrombin activator (tPA) etc. to increase cerebral blood flow, antithrombotic, and anticoagulant treatment. However, because the drug needs to be taken for a long time, it is prone to adverse reactions including cardiac depressi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/344A61P9/10A61K31/365A61K31/045
CPCA61K31/045A61K31/365A61K36/344A61P9/10A61K2300/00
Inventor 喻斌阮鸣程海波孙东东姚瑶张晓枫
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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