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Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor

A technology of hyaluronic acid and polylysine, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and other household appliances to achieve excellent hemostatic function, adhesion, and fast blood absorption

Inactive Publication Date: 2020-04-10
优瑞株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem with hyaluronic acid is that when it is used alone, it is decomposed in a relatively short period of time in the body, and it spreads out from the surface of the wound in a short period of time.
In order to compensate for this property of hyaluronic acid, a method of preparing a hyaluronic acid gel composition by chemical crosslinking using BDDE, DVS, EDC / HoBt, etc. is proposed, but a complicated process of removing the crosslinking agent is required, and carboxyl The use of additives such as methyl cellulose may cause safety problems due to biodegradability, etc.

Method used

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  • Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor
  • Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor
  • Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 6 and comparative example 1、2

[0066] Examples 1 to 6 and Comparative Examples 1 and 2: Manufacture of Foam Wound Covering (Patch)

[0067] 5 g of hyaluronic acid was added to 450 ml of purified water, and stirred for 2 hours. 21.1 g of CaCl was dissolved in 50 ml of purified water, added to the above solution, and stirred slowly at room temperature for 3 hours to produce hyaluronic acid-calcium salt. After that, HA and PLL adjusted to pH 8.4, respectively, were mixed in the amounts shown in the following [Table 1] to prepare mixed liquids each having a total volume of 10 ml, the mixed liquids were allowed to stabilize at 0 to 4° C. for 6 to 10 hours, and then Freezing at -10 to -20°C for 10 to 12 hours, followed by freeze-drying, to manufacture HA-PLL foam-type wound coverings (hereinafter, also referred to as "HA-PLL patch" or "HA-Ca-PLL patch") sheet"), and observe whether foam is formed or not. The results are shown in Table 1 below. In Table 1, Comparative Examples 1 and 2 are patches made of only...

Embodiment 7

[0070] Embodiment 7: the manufacture of liquid type wound dressing

[0071] Sodium chloride was added to the mixed solution having the composition of Example 2 so as to have a concentration of 0.8%, and the resulting solution was charged into a prefilled syringe, thereby preparing a liquid-type wound covering.

Embodiment 8

[0072] Example 8: Manufacture of film-type wound dressing

[0073] The mixed liquid having the composition of Example 2 was poured into a mold with a size of 10 cm×10 cm, and placed in a thermostat at 40° C. for 12 to 16 hours to manufacture a film-type wound covering.

[0074] figure 1 These are photographs showing the appearance of the patches produced in Examples 1 to 6 and Comparative Examples 1 and 2. As above Table 1 and figure 1 As shown, the compositions of Examples 1 to 6 all formed patches well. However, the higher the HA content, the stiffer the patch was, showing a tendency to stiffen the patch even with increasing PLL content. On the other hand, when the PLL content in the production liquid exceeds 0.75% (w / v) or the HA content exceeds 1% (w / v), it becomes brittle due to too high hardness. Therefore, in the case of providing the wound dressing in a foam type or a film type, an HA content of not more than 1.0% and a PLL content of not more than 0.75% are evalua...

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Abstract

The present invention relates to a wound dressing comprising hyaluronic acid-calcium and polylysine, and a manufacturing method therefor, the method comprising: (1) a step for adjusting each of the pHvalues of a hyaluronic acid-calcium salt and a polylysine aqueous solution to 8.4 or higher, and then mixing the hyaluronic acid-calcium salt and the polylysine aqueous solution to obtain a mixture liquid; and (2) obtaining a wound dressing from the mixture liquid obtained in step (1).

Description

technical field [0001] The invention relates to a wound dressing comprising hyaluronic acid-calcium and polylysine and a manufacturing method thereof. Background technique [0002] Damage to blood vessels from surgery and trauma to the body can lead to bleeding. Minor superficial bleeding is eventually stopped by a complex cascade of blood vessels, platelets, and plasma factors known as physiological hemostasis. However, in severe cases of bleeding, surgical and medical methods of hemostasis are required. For surgical hemostasis, surgical hemostasis can be assisted by suturing the ruptured blood vessel or covering the wound site with a hemostatic sponge. Such a hemostatic sponge or composition is useful in surgery, vascular surgery, dental surgery, and the like. [0003] Hemostatic products developed in the past include: sponge-shaped Topical Thrombin, which contains blood clotting factors in the body that promote blood clotting; and etc., which exhibit a blood coag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/22A61L15/28A61L15/32
CPCA61L15/225A61L26/0052A61L15/44A61L15/46A61L15/425A61L15/64A61L26/0066A61L26/0085A61L26/009A61L2300/252A61L2300/10A61L2300/236A61L2300/404A61L2300/424A61L2300/418A61L2400/04C08L5/08C08L77/04A61L15/28A61L15/32A61K31/728A61K31/785B29C35/16B29K2105/04B29L2031/753
Inventor 严香梅薛慈英
Owner 优瑞株式会社
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