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Medical hemostatic sponge material and preparation method thereof

A technology of hemostatic sponge and polyvinyl alcohol, which is applied in the field of medical materials, can solve the problems of slow metabolism, deficiency, and easy infection, and achieve the effects of high liquid absorption rate, fast water absorption rate, and excellent hemostatic effect

Active Publication Date: 2020-03-31
BEIJING YINGJIA MEDICAL MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oxidized cellulose, chitosan in polysaccharide hemostatic powder, and some synthetic polymer biomaterials lack relevant metabolic enzymes in normal human tissues, resulting in slow metabolism of these materials in the body and easy to cause infection

Method used

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  • Medical hemostatic sponge material and preparation method thereof
  • Medical hemostatic sponge material and preparation method thereof
  • Medical hemostatic sponge material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0044] Dissolve 10kg of tapioca starch and 5kg of potato starch in 30kg of water to form a suspension, heat and gelatinize at 65°C for 40min, after standing for 10min, add sodium acetate buffer until the pH of the mixture is 4.0, and obtain starch paste;

[0045] Add 0.3kg of glucoamylase to sodium acetate buffer solution to prepare an enzyme solution with a pH of 4.0, add the enzyme solution to the starch paste, stir and react at 60°C for 15 hours to obtain a mixed solution, then centrifuge the mixed solution, and wash 3 times Afterwards, dry at 40° C. and pulverize with a ball mill to obtain porous starch.

preparation example 2

[0047] Dissolve 15kg of tapioca starch and 5kg of potato starch in 50kg of water to form a suspension, heat and gelatinize at 67°C for 60min, after standing for 15min, add sodium acetate buffer until the pH of the mixture is 4.5, and obtain starch paste;

[0048] Add 1 kg of glucoamylase into sodium acetate buffer solution to prepare an enzyme solution with a pH of 4.5, add the enzyme solution to the starch paste, stir and react at 62°C for 20 hours to obtain a mixed solution, then centrifuge the mixed solution, and wash 3 times Dry at 45°C, and the porous starch will be obtained after ball milling.

preparation example 3

[0050] Carry out according to the method in the preparation example 1, difference is that the addition of tapioca starch is 15kg.

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Abstract

The invention discloses a medical hemostatic sponge material and a preparation method thereof. The preparation method comprises the following steps: S1, preparing materials; to be specific, dissolvingpolyvinyl alcohol in water to obtain a polyvinyl alcohol aqueous solution; S2, adding a catalyst and a cross-linking agent into the polyvinyl alcohol aqueous solution and making a reaction for 15 to25 minutes; and S3, adding porous starch, making a stirring reaction at a temperature of 60 to 65 DEG C and a rotating speed of 800 to 1000 rpm, and carrying out curing to obtain hemostatic sponge. The porous starch is obtained by conducting pre-gelatinization on potato starch and cassava starch to obtain a starch paste and then carrying out enzymolysis on the starch paste by using saccharifying enzyme liquid. According to the invention, the obtained hemostatic sponge material has advantages of being high in liquid absorption rate, good in hemostatic effect and is capable of being used for massive hemorrhage with high safety and efficiency.

Description

technical field [0001] The invention relates to the technical field of medical materials, more specifically, it relates to a medical hemostatic sponge material and a preparation method thereof. Background technique [0002] Negative pressure drainage therapy is a wound treatment method that uses a negative pressure suction device to connect with a wound dressing to intermittently or continuously generate pressure below atmospheric pressure on the wound to promote wound healing. Negative pressure drainage technology is widely used in burns, wound repair and In the field of plastic surgery, negative pressure stimulates the growth of granulation to promote recovery. [0003] As a new type of hemostatic material, biomedical materials have the advantages of absorbability, high efficiency, and economy, and are widely used in negative pressure drainage therapy. Currently, the most common hemostatic materials on the market are polysaccharide materials, protein materials, and oxidize...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/42A61L15/44A61L15/50A61L15/64C08B30/18C08J9/00
CPCA61L15/24A61L15/28A61L15/42A61L15/425A61L15/44A61L15/50A61L15/64A61L2300/232A61L2400/04C08B30/18C08J9/00C08J2303/02C08L3/02C08L29/04
Inventor 朱铁桥
Owner BEIJING YINGJIA MEDICAL MATERIAL CO LTD
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