Naringin preparations for improving male osteoporosis to prevent bone fracture

Abstract

Along with the increase of age, the testosterone levels of middle-aged and elderly men are gradually reduced and the bone biomechanical properties are reduced, so that bone fracture and osteoporosis easily occur. The research discovers that a preparation composed of naringin and fructose can replace testosterone to prevent male osteoporosis and reduced bone biomechanical properties. The naringin is natural flavanone glycosides and the fructose is a special energy supplement; and the naringin and fructose are combined according to the ratio of 1: (3-4) to prepare oral liquid, a capsule, a tablet, a granule, oral liquid and beverage, thereby preventing and treating people suffering from the bone biomechanical property reduction and osteoporosis due to various factors. In addition, the invention also discloses formulas and production processes of naringin-fructose oral liquid, a naringin-fructose vitamin D calcium granule, a naringin-fructose estrogen tablet, and a naringin-fructose aspirin tablet. The products have good effects on preventing male osteoporosis and low bone biomechanical function as well as the good curative effect on female osteoporosis patients.

Description

technical field [0001] The invention belongs to the technical field of health food and medicine production, and specifically relates to a group of naringin preparations for improving male osteoporosis and preventing fractures. Background technique [0002] With the aging of my country's population, the elderly population continues to increase, and the incidence of osteoporosis in the male population is also gradually increasing. According to the survey, the overall prevalence of osteoporosis in the male population over 50 years old in my country is 22.5%, and the incidence of fractures is 22.5%. It is 13%, which is higher than that of prostate cancer. The prevalence rate varies in different regions and age groups, but the overall trend remains upward. It is estimated that by 2050, the number of patients with osteoporosis in my country will reach 212 million, and the medical expenses due to osteoporotic fractures will reach 1.8 trillion (Lin X, et al., Clin Interv Aging, 2015)...

AI Technical Summary

Problems solved by technology

However, the effect of naringin on the testicle-removed animal model has not been observed so far. Whether naringin can help middle-aged and elderly osteoporosis patients with low testicular function in men, we used the testicle-removal method to establish the male The animal model of osteoporosis caused by hormone deficiency observed the effects of testosterone and naringin on the decline of bone biomechanical properties and osteoporosis in mice caused by androgen deficiency. At the same time, a series of drugs with naringin and The control drug of other drug combined prescription was observed, and it was found that naringin was given by intragastric administration of 300mg / kg and 600mg / kg solution for 8 consecutive weeks, and the bone biomechanical properties of the testicularized mice were significantly improved. It also has certain benefits for osteoporosis, and the differences are statistically significant

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