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Titanium metal-biological ceramic bone tissue engineering scaffold and preparation method thereof

A technology of bone tissue engineering and bioceramics, which is applied in the field of biomedical materials, can solve the problems of poor mechanical properties of pure bioceramic materials and insufficient biological activity of pure metal materials, so as to ensure biosafety, biocompatibility, and good structure. The effect of integrity, good mechanical properties

Inactive Publication Date: 2020-03-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the shortcomings of poor mechanical properties of pure bioceramic materials and insufficient biological activity of pure metal materials, and to prepare a titanium metal-bioceramic bone tissue engineering scaffold and its preparation method based on 3D printing technology

Method used

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  • Titanium metal-biological ceramic bone tissue engineering scaffold and preparation method thereof
  • Titanium metal-biological ceramic bone tissue engineering scaffold and preparation method thereof
  • Titanium metal-biological ceramic bone tissue engineering scaffold and preparation method thereof

Examples

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Embodiment 1

[0034] This embodiment provides the preparation method of the 3D printing titanium metal-bioceramic composite material and bone tissue engineering scaffold of the present invention, specifically:

[0035] According to the mass ratio of titanium alloy (Ti6Al4V) to hydroxyapatite (HA) being 75:25, 30 g of titanium alloy (Ti6Al4V) powder and 10 g of hydroxyapatite (HA) powder were taken. Take 50ml of deionized water and 38.5g of polyethylene glycol to prepare an aqueous solution, add 9ml of polyethylene glycol aqueous solution, 1ml+6 drops of glycerin, 10g of hydroxyapatite (HA) and 30g of titanium alloy in the defoamer (Ti6Al4V). Set the operating parameters of the defoamer: the first stage of powder mixing time is 1min, the speed is 500r / min, the defoaming time is 1min, and the speed is 1000r / min. In the second stage, the powder mixing time is 1min, the speed is 1000r / min, the defoaming time is 2min, and the speed is 1500r / min. Observe whether the ink is stirred evenly, other...

Embodiment 2

[0039] This embodiment provides the preparation method of the 3D printing titanium metal-bioceramic composite material and bone tissue engineering scaffold of the present invention, specifically:

[0040] The modeling, freeze-drying, and sintering process of the scaffold are the same as in Example 1, except that the 3D printing ink raw material is prepared in a different material batching method from that in Example 1. According to this embodiment, the mass ratio of titanium alloy (Ti6Al4V) to biphasic apatite (BCP) is 75:25, 40 g of titanium alloy (Ti6Al4V) powder and 10 g of biphasic apatite (BCP) are taken. Get 50ml deionized water and 38.5g Polyethylene Glycol to be mixed with aqueous solution, add 7.5ml Polyethylene Glycol aqueous solution, 0.5ml+5 drops of glycerol, 10g biphasic apatite (BCP) and 40g titanium alloy (Ti6Al4V). The parameter of defoamer is identical with example 1, until stirring evenly. Finally, it is freeze-dried and then sintered into shape.

[0041]...

Embodiment 3

[0043] This embodiment provides the preparation method of the 3D printing titanium metal-bioceramic composite material and bone tissue engineering scaffold of the present invention, specifically:

[0044] The modeling, freeze-drying, and sintering process of the scaffold are the same as in Example 1, except that the 3D printing ink raw material is prepared in a different material batching method from that in Example 1. According to this embodiment, the mass ratio of titanium alloy (Ti6Al4V) to tricalcium phosphate (TCP) is 75:25, 40 g of titanium alloy (Ti6Al4V) powder and 10 g of tricalcium phosphate (TCP) are taken. Take 50ml of deionized water and 38.5g of polyethylene glycol to prepare an aqueous solution, add 7.5ml of polyethylene glycol aqueous solution, 0.5ml+5 drops of glycerin, 10g of tricalcium phosphate (TCP) and 40g of titanium in the defoamer alloy (Ti6Al4V). The parameter of defoamer is identical with example 1, until stirring evenly. Finally, it is freeze-drie...

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Abstract

The invention discloses a titanium metal-biological ceramic bone tissue engineering scaffold and a preparation method thereof. The titanium metal-biological ceramic bone tissue engineering scaffold isof a multi-layer microporous structure, the porosity is 5%-85%, and the wire diameter of a porous structure solid supporting material is 300-5000 [mu]m; the titanium metal-biological ceramic bone tissue engineering scaffold is formed by printing ink raw materials layer by layer; the ink raw materials comprise: 60 to 75wt% of a titanium metal and biological ceramic composite material, 10 to 16wt%of polyethylene glycol, 2 to 4wt% of glycerol and 13 to 20wt% of water. The preparation method of the titanium metal-biological ceramic bone tissue engineering scaffold comprises the following steps:S1, preparing a 3D printing ink raw material; S2, designing a model; S3, carrying out 3D printing of a target model blank; and S4, sintering the blank and molding to obtain the titanium metal-biological ceramic bone tissue engineering scaffold.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a titanium metal-bioceramic bone tissue engineering scaffold and a preparation method thereof. Background technique [0002] Bone defect is an important subject that has been troubling people clinically. Scaffold materials, as an important part of bone tissue engineering, provide cells with a space structure for adhesion, proliferation, differentiation, and growth templates, and can guide tissue regeneration. Functionally, they must have good biological activity, compatibility, and inducibility. At the same time, certain mechanical properties are also required in different parts or functions. At present, for bone repair engineering, calcium phosphate bioceramic materials and medical metal materials are the main application materials. Calcium phosphate bioceramic materials have good biocompatibility and bioactivity, and can form a firm osseointegration with natural ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/12A61L27/06A61L27/18A61L27/50A61L27/56A61L27/58B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/06A61L27/12A61L27/18A61L27/50A61L27/56A61L27/58A61L2300/412A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L71/02
Inventor 周长春范洪远易涛雷皓远鲜广樊渝江蒋青张兴栋
Owner SICHUAN UNIV
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