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Eucommia bark waist-tonifying mixture and application thereof

A technology of solvents and pig kidneys, applied in the field of composition pharmaceuticals, to achieve the effect of improving endocrine disorders and repairing damaged ovaries

Active Publication Date: 2020-03-06
HUBEI WEISHI BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is used for waist and leg pain, fatigue and weakness, lack of energy, frequent urination, and its efficacy in treating premature ovarian failure has not been seen yet.

Method used

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  • Eucommia bark waist-tonifying mixture and application thereof
  • Eucommia bark waist-tonifying mixture and application thereof
  • Eucommia bark waist-tonifying mixture and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0016] 1. Preparation of Pig Kidney Extract

[0017] The invention provides a preparation method of pig kidney extract, which comprises the steps of: preparing pig eyeballs through extraction, adsorption, refining and post-treatment.

[0018] Extraction: Take the pig kidney cortex, homogenize it in the first solution at 2-8°C, take the supernatant after solid-liquid separation, precipitate the supernatant with solvent, dissolve the precipitate in the second solution, add solvent to extract, centrifuge, absorb The centrifuged aqueous layer was concentrated by ultrafiltration in the second solution to obtain the first concentrated solution.

[0019] Specifically, the first solution is selected from sodium chloride solution (H1), PBS solution (H2), disodium hydrogen phosphate-sodium chloride solution (H3), potassium dihydrogen phosphate-dipotassium hydrogen phosphate buffer solution (H4) and One of potassium dihydrogen phosphate-sodium hydroxide buffer (H5). The second solution...

Embodiment 1

[0032] Embodiment 1: 150 parts of pig kidney extract of embodiment 3, 200 parts of Eucommia ulmoides, 120 parts of Rehmannia glutinosa, 85 parts of Codonopsis pilosula, 200 parts of angelica, 50 parts of medlar, 120 parts of psoralen, 80 parts of Achyranthes bidentata, 50 parts of dodder , 40 parts of Ligustrum lucidum, wherein the Chinese medicinal materials are obtained by boiling the liquid at high temperature with water for 2 hours according to the above ratio, and the solid matter obtained after freeze-drying is formulated with the extract of pig kidney to make Eucommia tonic mixture, which is an oral solution.

Embodiment 2

[0033] Embodiment two: 100 parts of pig kidney extract of embodiment 3, 200 parts of Eucommia ulmoides, 120 parts of rehmannia glutinosa, 85 parts of Codonopsis pilosula, 200 parts of angelica, 50 parts of medlar, 120 parts of psoralen, 80 parts of Achyranthes bidentata, 50 parts of dodder , 40 parts of Ligustrum lucidum, wherein the Chinese medicinal materials are obtained by boiling the liquid at high temperature with water for 2 hours according to the above ratio, and the solid matter obtained after freeze-drying is formulated with the extract of pig kidney to make Eucommia tonic mixture, which is an oral solution.

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Abstract

The invention discloses a eucommia bark waist-tonifying mixture and application thereof. A pig kidney extracting solution used in the eucommia bark waist-tonifying mixture is prepared through four steps of extraction, salting-out, chromatography and aftertreatment. The eucommia bark waist-tonifying mixture is prepared from the following raw materials in parts by mass: 80-150 parts of pig kidney extract which is obtained by freeze-drying the pig kidney extracting solution, 200-205 parts of eucommia bark, 120-125 parts of prepared rehmannia roots, 80-85 parts of codonopsis pilosula, 200 parts ofangelica sinensis, 50 parts of fructus lycii, 120-125 parts of fructus psoraleae, 80-85 parts of radix achyranthis bidentatae, 50 parts of semen cuscutae and 40 parts of glossy privet fruits. By controlling process parameters of a preparation method, the yield of the obtained pig kidney extracting solution is as high as 763.5 mg / kg. Rat tests show that the eucommia bark waist-tonifying mixture prepared from the pig kidney extract has an application prospect as a medicine for treating premature ovarian failure.

Description

technical field [0001] The invention relates to the technical field of composition medicaments, in particular to a eucommia tonic mixture and its application. Background technique [0002] Pig kidney, commonly known as pig loin, has the functions of invigorating the kidney, curing deficiency, promoting body fluid and quenching thirst, and can be used for symptoms such as kidney deficiency, edema, and deafness. Pig kidney contains zinc, iron, copper, phosphorus, vitamin A, B vitamins, vitamin C, protein, fat, carbohydrates and other nutrients. "Materia Medica" pickled this product with pepper and salt to remove the fishy water, added 10g of Eucommia powder, wrapped it in lotus leaves and simmered it, and used it to treat kidney deficiency and low back pain. The Eucommia Buyao mixture prepared from this mainly contains Eucommia ulmoides, Rehmannia glutinosa, Codonopsis pilosula, Angelica, Lycium barbarum, Psoralen, Achyranthes bidentata, Cuscuta seed, pork kidney, shiitake mu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P15/08A61K35/22
CPCA61K35/22A61K36/46A61K36/804A61K36/344A61K36/232A61K36/815A61K36/487A61K36/21A61K36/39A61K36/43A61K36/638A61P15/08A61K2300/00
Inventor 罗先隽
Owner HUBEI WEISHI BIO PHARMA
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