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Application of pyrazolopyrimidine derivative in treatment of autoimmune thyroid diseases

A pyrazolopyrimidine, autoimmune technology, applied in the field of pyrazolopyrimidine derivatives for the treatment of autoimmune thyroid diseases, can solve problems such as no use of autoimmune thyroid diseases, and achieve the expansion of drug selectivity, The effect of extending the scope of application

Active Publication Date: 2020-02-25
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there are only reports about pyrazolopyrimidine derivatives in the treatment of acute myeloid leukemia and psoriasis, but there is no use in the treatment of autoimmune thyroid diseases

Method used

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  • Application of pyrazolopyrimidine derivative in treatment of autoimmune thyroid diseases
  • Application of pyrazolopyrimidine derivative in treatment of autoimmune thyroid diseases
  • Application of pyrazolopyrimidine derivative in treatment of autoimmune thyroid diseases

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Experimental program
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Embodiment 1

[0036] The influence of embodiment 1 on EAT mouse thyroid pathological structure and hormone, antibody level

[0037] 1. Experimental animals: ICR mice, female, weighing 18-22 g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0038] 2. Experimental materials: pyrazolopyrimidine derivatives were synthesized by the inventors. Mix castor oil and ethanol 1:1 and pass through a 0.22 μm sterile filter membrane to obtain ELE solution, weigh a certain amount of pyrazolopyrimidine derivative powder of the present invention, dissolve the powder with ELE solution, and after the powder is completely dissolved, Add a certain volume of sterilized water, mix well and set aside. The volume ratio of ELE solution to sterile water is 1:3. Porcine thyroglobulin (PTg, sigma company). Periodic iodine solution (0.64g potassium iodide dissolved in 1L distilled water). Preparation with complete Freund's adjuvant: Mix liquid paraffin and emulsifier lanolin in a rati...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of a pyrazolopyrimidine derivative in treating autoimmune thyroid diseases. The pyrazolopyrimidine derivativehas the good treatment effect on autoimmune thyroid diseases, can significantly reduce the levels of T3, T4, FT3, FT4 and other thyroid hormones in serum, significantly reduces the levels of antibodies TMAb and TGAb in serum, and effectively improves the infiltration condition of lymphocytes in thyroid tissues. The treatment effect of the pyrazolopyrimidine derivative on autoimmune thyroid diseases is equivalent to that of thyroxine or prednisone.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the use of pyrazolopyrimidine derivatives in treating autoimmune thyroid diseases. Background technique [0002] Autoimmune thyroid disease (AITD), which accounts for 30% of all autoaggressive diseases, is an organ-specific autoimmune disease. Among them, chronic lymphocytic thyroiditis (chroniclymphocyticthyroiditis, CLT) and Graves' disease (Graves Disease, GD) are the most common. The former is also known as Hashimoto’s thyroiditis (Hashimoto’s thyroiditis, HT), which is characterized by the presence of high titer thyroid autoantibodies in the serum, accompanied by the infiltration of thyroid lymphocytes, which gradually destroy the gland and eventually lead to clinical hypothyroidism and Fibrosis of thyroid tissue. At present, it is generally believed that its pathogenesis may be due to genetic susceptibility of humans or animals, due to the influence of pathogenic factor...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P37/00A61P5/14
CPCA61K31/519A61P37/00A61P5/14
Inventor 陈焕展巫鑫李柏霖钟杰敏赖树生李鑫林艳英黄源春
Owner GUANGXI WUZHOU PHARMA GRP
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