The establishment method of the fingerprint of Yaoshen ointment and the control fingerprint of Yaoshen ointment
A technology for comparing fingerprints and fingerprints, which is applied in the field of pharmaceutical analysis, and can solve problems such as multiple components and complexity
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Embodiment 1
[0056] Embodiment 1: Methodological verification
[0057] Select six batches of Yaoshen ointment of 18046, and prepare the test solution according to the proposed method. Take the first copy for precision and stability inspection; a total of six copies for repeatability inspection.
[0058] Preparation of the test solution: Take three pieces of waist and kidney paste, cut them into strips, tear off the backing, combine them into a group with one piece as a unit, stuff them into a 250ml flask, add 100ml of water, and connect with 2ml of ethyl acetate to extract the volatile oil. reflux on the electric heating mantle for 3 hours; let cool after reflux, put the ethyl acetate layer of the volatile oil extractor into a separatory funnel, rinse the volatile oil extractor with 2ml, 2ml, and 1ml of ethyl acetate respectively, wash the solution and Put it into a separatory funnel, discard the water layer, pass the ethyl acetate layer through the filter paper loaded with 1g of anhydrou...
Embodiment 2
[0087] Embodiment 2: the establishment of the fingerprint of Yaoshen ointment
[0088] 1. Exclude excipient peaks
[0089] 1. Peak of auxiliary materials in liquid chromatography
[0090] Waist and kidney ointment is made by spreading the mixed ointment on elastic cloth. The elastic cloth is soaked in methanol and ethanol, so that the dye on the elastic cloth is eluted and enters the test solution. For this reason, try to use 50% ethanol and 50% methanol to reflow the elastic cloth of Yaoshen plaster to reduce the amount of eluted dye, so as to reduce the interference of similarity evaluation.
[0091] Chromatographic conditions: Instrument: Agilent 1100 high performance liquid chromatography. The elution conditions are shown in Table 3 below. Other chromatographic conditions are the same as the experimental conditions proposed in Example 1.
[0092] table 3
[0093] time min Acetonitrile (%) 0.02% trifluoroacetic acid solution (%) 0 30 70 20 60 ...
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