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Composition and preparation method thereof

A technology of composition and extract, which is applied in the field of composition and its preparation, can solve the problems of no preparation process, etc., and achieve the effects of reducing bitterness and improving stability

Pending Publication Date: 2020-02-14
王京杭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In a word, there is no dihydromyricetin-caffeine-resistant dextrin / or cyclodextrin (DMY-CAF-RS / CD) composition and preparation process thereof according to the present invention

Method used

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  • Composition and preparation method thereof
  • Composition and preparation method thereof
  • Composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Research on Composition Formulation

[0060] Method: Take appropriate amount of dihydromyricetin (DMY≥98%), caffeine (CAF≥98%) or guarana extract (CAF≥22%), resistant dextrin (RS, food grade) or cyclodextrin (CD, food grade), mixed with an appropriate amount of pure water, heated to 80°C for 10 minutes under stirring to dissolve, divided into screw-top test tubes (10ml / tube), and sterilized in a water bath at 90°C for 10 minutes to prepare DMY respectively 10mg / ml-CAF series aqueous solution, DMY 10mg / ml-RS 6%-CAF series aqueous solution, DMY 10mg / ml-γ-CD 10mg / ml-CAF series aqueous solution, etc. Then put the test samples at room temperature (20-30°C) and in the refrigerator (4°C) for observation for at least 30 days. The solubility (or stability of properties) of DMY and its composition is evaluated by the mass or volume percentage of the amount of sediment in the solution, and the low temperature solubility is more sensitive; the taste (bitterness) of the solution is...

Embodiment 2

[0071] Composition Stability Studies

[0072] Method: refer to the method of Example 1, adjust the pH with dilute acetic acid and dilute NaOH, and prepare DMY 10mg / ml-CAF 2mg / ml series aqueous solutions (pH7.0-3.0) and RS (or CD) containing series aqueous solutions with different pH values etc., and then use the high temperature accelerated oxidation method (95 ℃ × 2 hours) to process the sample, after cooling to room temperature, dilute it with water to measure its browning index (OD410nm) 10 times colorimetrically, and observe its property stability (precipitation reaction) and DMY content.

[0073] The results show:

[0074] 1) The anti-browning effect of the aqueous solution of DMY-CAF-RS and DMY-CAF-CD composition increases with the decrease of pH (browning index decreases), that is, it has better anti-browning stability under the condition of increasing acidity role (see attached figure 2 ). In the pH neutral-acidic range, the aqueous solution of DMY-CAF-RS (or CD) ...

Embodiment 3

[0077] Preparation of Dihydromyricetin Oral Liquid

[0078]

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Abstract

The invention provides a composition and a preparation method thereof. The invention discovers that caffeine has significant synergistic solution-promoting and stabilizing effects on dihydromyricetinand a composition of the dihydromyricetin and resistant dextrin (or cyclodextrin); and the resistant dextrin (or cyclodextrin) has sensory quality improving (debitterizing) and stabilizing enhancing effects on the composition, a dihydromyricetin-caffeine-dextrin (or cyclodextrin) composition and a preparation process thereof are research and developed thereby, and important industrial applicationvalue is achieved.

Description

[0001] field of invention [0002] The invention relates to a composition and a preparation method thereof. More specifically, the present invention relates to a composition rich in dihydromyricetin-caffeine-resistant dextrin / or cyclodextrin and a preparation method thereof. Background technique [0003] Dihydromyricetin (DMY), also known as ampelopsin, is a white needle-like crystal, slightly soluble in water, and easily soluble in hot water, ethanol and acetone. DMY is a natural dihydroflavonol compound, mainly derived from vine tea, also known as Maoyanberry tea, nectar tea, etc. (Ampelopsis megalophylla Diels et.Gilg) and other plants, the DMY content in the young leaves and tea tips of vine tea can usually reach more than 20%, which is the known plant source with the highest DMY content. Vine tea contains no or very little (negligible) caffeine. Pharmacological studies have shown that DMY has significant anti-inflammatory, anti-oxidation, weight loss, blood fat lowerin...

Claims

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Application Information

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IPC IPC(8): A61K47/22A61K47/36A61K47/40A61K31/352A61P29/00A61P39/06A61P3/04A61P3/06A61P9/12A61P3/10A61P1/16A23L2/38A23L2/39A23L33/105A23L33/21
CPCA61K47/22A61K47/36A61K47/40A61K31/352A61P29/00A61P39/06A61P3/04A61P3/06A61P9/12A61P3/10A61P1/16A23L2/38A23L2/39A23L33/105A23L33/21A23V2002/00A23V2250/21A23V2250/2108A23V2250/5112A23V2250/5114
Inventor 王京杭
Owner 王京杭
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