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Preparation method of novel fucoxanthin-supporting fucoidan nanoparticle

A technology of copper algae fucoidan sulfate and fucoidan sulfate, which is applied in the field of preparation of fucoidan sulfate nanoparticles to achieve the effect of improving stability, good stability and good market prospects

Inactive Publication Date: 2020-02-11
BIOLOGY INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, fucoidan sulfate is one of the polysaccharides commonly used to construct nanoparticle carriers, but at present, commercialized kelp and fucoidan fucoidan sulfate are mostly used for the preparation of nanoparticles. Fucoidan sulfate from other brown algae sources Research on sugar sulfates is still sparse

Method used

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  • Preparation method of novel fucoxanthin-supporting fucoidan nanoparticle

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A new type of fucoxanthin-loaded fucoidan sulfate nanoparticles. The nanoparticles are formed by copper alginate fucoidan sulfate and chitosan through the method of polyelectrolyte self-assembly. During the self-assembly process, copper alginate is wrapped Alcoxanthin, chitosan deacetylation degree is 85%.

Embodiment 2

[0032] For the novel fucoxanthin-loaded fucoidan sulfate nanoparticles described in Example 1, the total sugar content of the copper algae fucoidan sulfate is 52.45%, the protein content is 7.96%, and the sulfate group content The content of uronic acid is 26.72%, the content of uronic acid is 9.25%, the molecular weight is 341.7kDa, the monosaccharide composition is fucose, galactose, mannose, glucuronic acid, and xylose, and the ratio is 1:0.85:0.41:0.34:0.15 ( The molar ratio of).

Embodiment 3

[0034] In the novel fucoxanthin-loaded fucoxanthin nanoparticles described in Example 1, the fucoxanthin is extracted from copper algae and is determined to be fucoxanthin by high performance liquid chromatography, The yield was 0.38 mg / g.

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Abstract

The invention discloses a novel fucoxanthin-supporting fucoidan nanoparticle. The nanoparticle is formed by a method of polyelectrolyte self-assembly of fucoidan from sargassum horneri and chitosan, fucoxanthin from sargassum horneri is coated in the self-assembly process, and the deacetylation degree of the chitosan is 85%. The preparation method is used for preparing the novel fucoxanthin-supporting fucoidan nanoparticle.

Description

technical field [0001] The invention relates to a preparation method of novel fucoidan sulfate nanoparticles loaded with fucoxanthin. Background technique [0002] Oral administration is simple, does not damage the skin and mucous membranes, and has no cross-infection. It is the most commonly used route of drug therapy and the only way to use health food. However, the stability of active ingredients of drugs and health foods in the gastrointestinal tract environment greatly limits their utilization. How to improve the oral utilization of drugs and health food is still an urgent problem to be solved at this stage. In recent years, nano-drug loading system, which is a research hotspot in the field of preparation, has attracted widespread attention. The nano drug loading system has small particle size, high particle dispersion and strong adhesion, which can improve the stability of the loaded active substance, increase the absorption and utilization of the active substance by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/36A61K31/336C07D303/32C08B37/00A23L33/125
CPCA61K9/5161A61K9/5192A61K31/336A23L33/125C07D303/32C08B37/0003
Inventor 刘雪刘昌衡贾爱荣刘新史亚萍王加祥张绵松白新峰
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI
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