Curcumin piperine preparation, and preparation method and application thereof

A technology of curcumin piperine and piperine, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the lack of early clinical diagnosis and treatment, and the unclear process of histopathological changes , high mortality of patients with severe heat stroke, etc., to achieve the effect of improving bioavailability, uniform distribution of the main drug, and good mixing

Active Publication Date: 2020-02-07
INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the mechanism of cell damage and histopathological changes caused by heatstroke are still unclear, and there is a lack of effective early clinical diagnosis and treatment, resulting in high hospitalization costs and high mortality in severe heatstroke patients. prevention first

Method used

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  • Curcumin piperine preparation, and preparation method and application thereof
  • Curcumin piperine preparation, and preparation method and application thereof
  • Curcumin piperine preparation, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The preparation method of curcumin piperine capsule preparation in the present embodiment is as follows:

[0063] (1) Prepare preparation raw materials according to the following components and proportioning, the main ingredients are curcumin and piperine with a weight ratio of 10:1, and the auxiliary materials include diluents, lubricants and solvents, wherein the diluents are curcumin and piperine with a weight ratio of 2:1 Corn starch and / or potato starch and dextrin, dextrin is water-soluble maltodextrin prepared by enzymatic method, which is prepared by low-level controlled hydrolysis conversion, purification and drying by enzymatic process, the lubricant is PEG4000, diluent and lubricating agent The weight ratio of agent is 1.5:1, and solvent is the ethanol solvent that weight concentration is 75%, and the weight ratio of principal agent and solvent is 4:1, and the weight ratio of principal agent and auxiliary material is 2:1;

[0064] And choose the pharmacopoeia...

Embodiment 2

[0069] The preparation method of curcumin piperine capsule preparation in the present embodiment is as follows:

[0070] (1) Prepare preparation raw materials according to the following components and proportions, the main ingredients are curcumin and piperine in a weight ratio of 9:1, and the auxiliary materials include diluents, lubricants and solvents, wherein the diluents are curcumin and piperine in a weight ratio of 2.6:1 Potato starch and dextrin, dextrin is water-soluble maltodextrin prepared by enzymatic method, which is prepared by low-level controlled hydrolysis conversion, purification and drying by enzymatic process, the lubricant is PEG4000, and the weight ratio of diluent and lubricant is 1:1, the solvent is an ethanol solvent with a weight concentration of 70%, the weight ratio of the main ingredient to the solvent is 3:1, and the weight ratio of the main ingredient to the auxiliary material is 1.5:1;

[0071] And select Pharmacopoeia Standard No. 1 capsule she...

Embodiment 3

[0076] The preparation method of curcumin piperine capsule preparation in the present embodiment is as follows:

[0077] (1) Prepare preparation raw materials according to the following components and proportioning, the main ingredients are curcumin and piperine with a weight ratio of 11:1, and the adjuvants include diluents, lubricants and solvents, wherein the diluents are curcumin and piperine with a weight ratio of 1.5:1 Corn starch and dextrin, dextrin is water-soluble maltodextrin prepared by enzymatic method, which is prepared by low-level controlled hydrolysis conversion, purification and drying by enzymatic process. The lubricant is PEG4000, and the weight ratio of diluent and lubricant is 2:1, the solvent is an ethanol solvent with a weight concentration of 90%, the weight ratio of the main drug to the solvent is 5:1, and the weight ratio of the main drug to the auxiliary material is 2.5:1;

[0078] And choose the pharmacopoeia standard No. 1 capsule shell, store it ...

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Abstract

The invention relates to a curcumin piperine preparation, and a preparation method and application thereof, and belongs to the technical field of pharmacy. The curcumin piperine preparation comprisesprimary medicines and auxiliary materials, wherein the primary medicines are curcumin and piperine according to a weight ratio of (9 to 11):1; the auxiliary materials comprise a diluent, a lubricatingagent and a solvent; and the weight ratio of the primary medicines to the auxiliary materials is (1.5 to 2.5):1. The mixing condition of the primary medicines and the auxiliary materials of the curcumin piperine preparation is good; the distribution of the primary medicines is uniform; and conditions of auxiliary material agglomeration and primary medicine cladding do not exist, so that the medicine stability can be effectively ensured through the primary medicines, and the medicine effect of the primary medicines is effectively achieved. The curcumin piperine preparation can be applied to resistance of female genital inflammatory reaction effect caused by heat injury effects and heat stress effects, can be taken for a long time, and has high safety.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a curcumin piperine preparation, a preparation method and application thereof. Background technique [0002] Curcumin is a natural plant compound, a yellow phenolic compound extracted from turmeric, turmeric, curcuma, curry, etc., and is the main component of dietary turmeric. Turmeric has been used as a medicinal material in ancient China and India, and it is most commonly used as a curry spice in modern times. Curcumin has a wide range of biological activities, including antioxidant, neuroprotective, anti-inflammatory, anti-aging, etc. (Du et al. 2012). Curcumin has high safety and effectiveness. As a health treatment drug under pathological conditions and a health care nutritional agent under healthy conditions, curcumin has rapidly gained attention in the field of pharmacology. However, due to poor water solubility, easy photolysis, and low oral bioavailability of curcumin, ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K31/12A61K31/4525A61P15/00
CPCA61K9/4866A61K31/12A61K31/4525A61P15/00A61K2300/00
Inventor 安改红杨丹凤王静马强李超安芳红陈学伟褚浩陈家俊
Owner INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI
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