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Simethicone compound recipe liquid composition and preparation method and application thereof

A technology of liquid composition and simethicone, which is applied in the field of medicine to achieve the effects of good stability, improved clinical curative effect, and enhanced defoaming ability

Active Publication Date: 2020-01-24
WUHAN DOCAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Functional abdominal distension is a type of functional enteropathy, often accompanied by anorexia, belching, borborygmus, and increased flatulence. It is not uncommon in clinical practice. Accompanied by a measurable increase in abdominal girth for which there is currently no recognized effective treatment

Method used

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  • Simethicone compound recipe liquid composition and preparation method and application thereof
  • Simethicone compound recipe liquid composition and preparation method and application thereof
  • Simethicone compound recipe liquid composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The compound liquid composition of embodiment 1 simethicone and itopride

[0038] The proportioning of the compound liquid composition of table 1 simethicone and itopride

[0039] Composition Dosage mass volume percentage Itopride Hydrochloride 1g 0.1％ Simethicone 40g 4％ Polyethylene glycol monostearate 30g 3％ Glyceryl monostearate 20g 2％ Carbomer 971 20g 2％ Sorbic acid 0.5g 0.05％ sodium saccharin 50g 5％ Acesulfame Potassium 0.1g 0.01％ banana flavor 0.1g 0.01％ sodium hydroxide Appropriate amount Appropriate amount purified water About 830ml 83％

[0040] The present embodiment takes Table 1 as a formula, and prepares pharmaceutical preparations by the following method:

[0041] (1) Stir and mix simethicone and emulsifier at 60-80°C to obtain an oil phase;

[0042] (2) stirring and dissolving itopride hydrochloride, flavoring agent, bacteriostat and 60% purified water of the ...

Embodiment 2

[0045] The compound liquid composition of embodiment 2 simethicone and itopride

[0046] The proportioning of the compound liquid composition of table 2 simethicone and itopride

[0047] Composition Dosage mass volume percentage Itopride Hydrochloride 2g 0.2％ Simethicone 20g 2％ Tween 40 14g 1.4％ Span 40 16g 1.6％ Carbomer 974 10g 1％ benzoic acid 0.5g 0.02％ liquid sorbitol 100g 10％ Acesulfame Potassium 0.2g 0.02％ orange flavor 0.2g 0.02％ sodium hydroxide Appropriate amount Appropriate amount purified water About 840ml 84％

[0048] The preparation method of this embodiment is the same as that of Example 1.

Embodiment 3

[0049] The compound liquid composition of embodiment 3 simethicone and mosapride

[0050] The proportioning of the compound liquid composition of table 3 simethicone and mosapride

[0051] Composition Dosage mass volume percentage Mosapride hydrochloride 0.5g 0.05％ Simethicone 5g 0.5％ Polyethylene glycol monostearate 6g 0.6％ Glyceryl monostearate 4g 0.4％ Carbomer Copolymer 20g 2％ Potassium sorbate 0.5g 0.05％ Sorbitol 80g 8％ Acesulfame Potassium 0.1g 0.01％ orange flavor 0.1g 0.01％ sodium hydroxide Appropriate amount Appropriate amount purified water About 880ml 88％

[0052] In this embodiment, Table 3 is used as a formula, and the pharmaceutical preparation is prepared by the following method:

[0053] (1) Stir and mix simethicone and emulsifier at 65-75°C to obtain an oil phase;

[0054] (2) stirring and dissolving mosapride hydrochloride, flavoring agent, bacteriostat and 70% pur...

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Abstract

The invention relates to a simethicone compound recipe liquid composition and a preparation method and application thereof. The simethicone compound recipe liquid composition comprises simethicone andgastric motility promoting medicines or pharmaceutically-acceptable salts of the gastric motility promoting medicines, wherein the gastric motility promoting medicines are one or two of Itopride, mosapride and cisapride, and the mass ratio of the simethicone to the gastric motility promoting medicines or the pharmaceutically-acceptable salts of the gastric motility promoting medicines is (10-40)to 1. The simethicone and the gastric motility promoting medicines are compounded in a specific proportion and are made into the form of a liquid preparation, so that the defoaming capacity is strengthened, and defoaming can be completed only within 3-5 seconds; and besides, the stability is good, and the simethicone compound recipe liquid composition can still maintain better preparation shape and better defoaming capacity after being stored for 30 days.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound liquid composition of simethicone and its preparation method and application. Background technique [0002] Functional abdominal distension is a type of functional enteropathy, often accompanied by anorexia, belching, borborygmus, and increased flatulence. It is not uncommon in clinical practice. Accompanied by a measurable increase in abdominal girth, there is currently no recognized effective treatment for this condition. Its etiology and pathogenesis have not yet been fully elucidated. In recent years, theories include accumulation of intestinal gas, food intolerance, intestinal fluid retention, weak abdominal muscles, abnormal visceral sensory and dynamic function, and psychological factors. Studies have shown that patients with functional abdominal distension have proximal colonic gas discharge obstruction, and gas accumulation in the proximal colon, and increas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/04A61K47/24A61K47/14A61P1/14A61K31/166A61K31/4468A61K31/5375
CPCA61K31/166A61K31/5375A61K31/4468A61K47/24A61K47/02A61K9/0095A61K47/14A61P1/14Y02A50/30
Inventor 黄岭张晓花尹磊胡金涛
Owner WUHAN DOCAN PHARMA
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