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Preparation method of polypropylene imine modified magnetic nanocrystalline cellulose molecular imprinted polymer

A technology of nanocrystalline cellulose and polypropylene imine, which is applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of low utilization rate of imprinted polymer molecules, and achieve the effect of improving utilization rate and simple and convenient operation.

Inactive Publication Date: 2020-01-17
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, Chinese Patent Publication No. CN104693353 discloses a method for preparing a molecularly imprinted polymer that can enrich paclitaxel, using paclitaxel as a template molecule, using acetone solvent as a porogen, using methacrylic acid as a functional monomer, and using ethylene glycol dimethyl Acrylate as cross-linking agent and azobisisobutyronitrile as initiator to prepare a molecularly imprinted polymer capable of separating pakinol from the crude extract of Taxus chinensis. In this technical scheme, ethylene glycol dimethyl Acrylate cross-linking agent, through functional monomer methacrylic acid = cross-linking to form imprinted polymer, the surface of the formed imprinted polymer solid particles is combined with imprinted template molecules, using a large amount of imprinted polymers and imprinted molecules can only form a small amount of binding sites, the utilization of imprinted polymer molecules is low

Method used

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  • Preparation method of polypropylene imine modified magnetic nanocrystalline cellulose molecular imprinted polymer

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Effect test

Embodiment 1

[0021] A method for preparing a polypropyleneimine-modified magnetic nanocrystalline cellulose molecularly imprinted polymer, comprising the following steps:

[0022] 1) Add 3g nanocrystalline cellulose to 150mL deionized water and ultrasonically disperse to form a dispersion liquid, add 2g FeCl to the dispersion liquid 3 ·6H 2 O and 5g FeCl 2 4H 2 O, dropwise adding sodium hydroxide with a concentration of 10 wt% to adjust the pH to 9.5, react at 35° C. for 3 h, separate the product from the solution with a magnet, wash, and dry to obtain magnetic nanocrystalline cellulose;

[0023] 2) Add 3-(2,3-epoxypropoxy)propyltrimethoxysilane into toluene solvent and stir to dissolve to obtain 2wt% 3-(2,3-epoxypropoxy)propyltrimethoxysilane Silane solution, adding the magnetic nanocrystalline cellulose obtained in step 1) to the solution, stirring and reacting, separating the solid product, washing, and drying to obtain alkylated magnetic nanocrystalline cellulose;

[0024] 3) addin...

Embodiment 2

[0027] A method for preparing a polypropyleneimine-modified magnetic nanocrystalline cellulose molecularly imprinted polymer, comprising the following steps:

[0028] 1) Add 3g nanocrystalline cellulose to 150mL deionized water and ultrasonically disperse to form a dispersion liquid, add 2g FeCl to the dispersion liquid 3 ·6H 2 O and 6g FeCl 2 4H 2 O, dropwise adding sodium hydroxide with a concentration of 10 wt% to adjust the pH to 10, react at 40° C. for 2 h, separate the product from the solution with a magnet, wash, and dry to obtain magnetic nanocrystalline cellulose;

[0029] 2) Add 3-(2,3-epoxypropoxy)propyltrimethoxysilane into toluene solvent and stir to dissolve to obtain 3-(2,3-epoxypropoxy)propyltrimethoxysilane with a concentration of 4wt%. Silane solution, adding the magnetic nanocrystalline cellulose obtained in step 1) to the solution, stirring and reacting, separating the solid product, washing, and drying to obtain alkylated magnetic nanocrystalline cellu...

Embodiment 3

[0033] A method for preparing a polypropyleneimine-modified magnetic nanocrystalline cellulose molecularly imprinted polymer, comprising the following steps:

[0034] 1) Add 3g nanocrystalline cellulose to 150mL deionized water and ultrasonically disperse to form a dispersion liquid, add 2g FeCl to the dispersion liquid3 ·6H 2 O and 4g FeCl 2 4H 2 O, dropwise adding sodium hydroxide with a concentration of 10 wt% to adjust the pH to 9.5, react at 30° C. for 5 h, separate the product from the solution with a magnet, wash, and dry to obtain magnetic nanocrystalline cellulose;

[0035] 2) Add 3-(2,3-epoxypropoxy)propyltrimethoxysilane into toluene solvent and stir to dissolve to obtain 3-(2,3-epoxypropoxy)propyltrimethoxysilane with a concentration of 1.5wt%. base silane solution, adding the magnetic nanocrystalline cellulose obtained in step 1) to the solution, stirring and reacting, separating the solid product, washing, and drying to obtain alkylated magnetic nanocrystalline...

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Abstract

The invention relates to the technical field of imprinted polymers, and discloses a preparation method of a polypropylene imine modified magnetic nanocrystalline cellulose molecular imprinted polymer.The preparation method comprises the following steps: 1) preparing magnetic nanocrystalline cellulose; 2) carrying out alkylation treatment; 3) adding alkylated magnetic nanocrystalline cellulose into a polypropylene imine solution to obtain polypropylene imine grafted nanocrystalline cellulose; and 4) adding the polypropylene imine grafted nanocrystalline cellulose, paclitaxel and a methacrylicacid monomer into an acetone solvent to carry out stirring and dissolving, adding ethylene glycol dimethacrylate and azobisisobutyronitrile, and carrying out heating for reacting to obtain the polypropylene imine modified magnetic nanocrystalline cellulose molecular imprinted polymer. According to the invention, nanocrystalline cellulose is use as a carrier, and the functional monomer methacrylicacid is crosslinked on the surface of a carrier to form spherical imprinted polymer microspheres. The spherical imprinted polymer microspheres have a high specific surface area, binding sites with template molecules are increased, and thus the utilization rate of imprinted polymer molecules is increased.

Description

technical field [0001] The invention relates to the technical field of molecularly imprinted polymers, in particular to a preparation method of polypropyleneimine-modified magnetic nanocrystalline cellulose molecularly imprinted polymers. Background technique [0002] Molecularly imprinted polymer, also known as molecular imprinting technology, belongs to an interdisciplinary field among polymer chemistry, material science, biochemistry, and analytical chemistry. Molecular imprinting technology is an experimental preparation technology for obtaining polymers that completely match a certain molecule in terms of spatial structure and binding sites. Molecularly imprinted polymers refer to the use of target molecules as template molecules, combining structurally complementary functionalized polymer monomers with template molecules through covalent or non-covalent bonds, and adding cross-linking agents for polymerization reactions. The template molecules are extracted to form a ...

Claims

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Application Information

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IPC IPC(8): B01J20/281C08F220/06C08F222/14C08J9/26
CPCB01J20/281C08F220/06C08F222/1006C08J9/26
Inventor 曲有乐欧阳小琨王南黄芳芳
Owner ZHEJIANG OCEAN UNIV
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