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Veterinary anhydrous calcium chloride enrofloxacin injection as well as preparation method and application thereof

A technology of anhydrous calcium chloride and enrofloxacin, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, inorganic non-active ingredients, etc., can solve problems such as barriers to application, loss of antibacterial activity, barriers, etc., to achieve stimulation The effect of small resistance and stable quality

Active Publication Date: 2020-01-14
庞燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the strong alkalinity of enrofloxacin injection will quickly destroy the chemical structure of penicillin and other β-lactam drugs, making them lose their antibacterial activity, which hinders the clinical practice of veterinary medicine to dissolve and mix the two in vitro before giving Injection of sick animals also hinders the application of the above-mentioned ideal drug regimen
[0007] At present, there is a lack of a preparation method that can produce acidic enrofloxacin injection and avoid "decarboxylation"

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] This example provides an anhydrous calcium chloride enrofloxacin injection for veterinary use. The mass fraction of enrofloxacin is 0.5%, and the total amount of the injection is 200,000 mL, which is prepared by the following method.

[0072] (1) Put 40,000 mL of propylene glycol, 16,000 mL of ethanol, and 130,000 mL of water for injection into the liquid mixing tank, and adjust the temperature to 43°C.

[0073] (2), drop into 200g of anhydrous calcium chloride. After stirring and dissolving, add 503.5 g of enrofloxacin (500 g of the active ingredient of enrofloxacin), and then divide the remaining 200 g of anhydrous calcium chloride and 503.5 g of enrofloxacin into 2 equal portions. Under slow stirring, add 1 equal part of enrofloxacin, 1 equal part of anhydrous calcium chloride, and 1 equal part of enrofloxacin every 3 minutes. Divide the last 1 equal part of anhydrous calcium chloride that has not been added into 5 equal parts, and slowly add in batches until the en...

Embodiment 2

[0077] This example provides an anhydrous calcium chloride enrofloxacin injection for veterinary use. The mass fraction of enrofloxacin is 1.0%, and the total amount of the injection is 200,000 mL, which is prepared by the following method.

[0078] (1) Put 40000mL propylene glycol, 16000mL ethanol, and 130000mL water for injection into the liquid mixing tank first, and adjust the temperature to 42°C.

[0079] (2) Add 400 g of anhydrous calcium chloride. Add enrofloxacin 1007g (active ingredient 1000g) during stirring, and stir to dissolve. , at the same time, divide 400g of anhydrous calcium chloride and 1007g of enrofloxacin into 3 equal parts respectively, and under slow stirring, add 1 equal part of enrofloxacin and 1 equal part of anhydrous calcium chloride in sequence every 3 minutes , until the enrofloxacin is finished, divide the remaining last 1 equal part of anhydrous calcium chloride into 7 small equal parts, slowly add in batches until the enrofloxacin is complete...

Embodiment 3

[0084] This example provides an anhydrous calcium chloride enrofloxacin injection for veterinary use. The mass fraction of enrofloxacin is 2.5%, and the total amount of the injection is 200,000 mL, which is prepared by the following method.

[0085] (1), first put 50000mL propylene glycol, 18000mL ethanol, and 120000mL water for injection into the liquid mixing tank, and adjust the temperature to 46°C.

[0086] (2), drop into 893g of anhydrous calcium chloride. After stirring and dissolving, 2517.5 g of enrofloxacin was added. At the same time, 893g of anhydrous calcium chloride and 2517.5g of enrofloxacin were divided into 3 equal parts respectively, and under slow stirring, 1 equal part of enrofloxacin and 1 equal part of anhydrous calcium chloride were added in sequence every 3 minutes. . After the third equal portion of enrofloxacin is finished, divide the remaining third equal portion of anhydrous calcium chloride into 7 small equal portions, and slowly put it into the ...

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PUM

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Abstract

The invention relates to a veterinary anhydrous calcium chloride enrofloxacin injection as well as a preparation method and an application thereof. The enrofloxacin injection is prepared from a composite solvent, enrofloxacin and anhydrous calcium chloride, wherein the composite solvent comprises the following components in percentage by volume: 20-40% of propylene glycol, 8-12% of ethanol and thebalance of water; wherein the mass ratio of the anhydrous calcium chloride to the enrofloxacin is 1: (2.5-3.2); wherein the mass fraction of enrofloxacin in the injection is 0.5%-10%; wherein a pH value of the injection is 4.0 to 6.0. The veterinary anhydrous calcium chloride enrofloxacin injection provided by the invention can avoid enrofloxacin decarboxylation, retains the antibacterial activity of enrofloxacin, is stable in quality, is not separated out when being placed at room temperature of 5 DEG C or above, is used for intramuscular injection of livestock and poultry, is small in irritation of an injection part, and conforms to related quality regulations of veterinary drugs; after intramuscular injection of livestock and poultry, the injection is metabolized and degraded into enrofloxacin and ciprofloxacin in vivo, and antibacterial activity is kept continuously.

Description

technical field [0001] The invention belongs to the field of production technology and application of veterinary medicines, and in particular relates to anhydrous calcium chloride enrofloxacin injection for veterinary use and a preparation method and application thereof. Background technique [0002] Penicillin has been widely used in the treatment of poultry bacterial infection diseases. However, bacterial resistance is increasing rapidly. With the continuous increase of bacterial resistance, the dosage of drugs is also increasing. The two are rising in a spiral vicious circle, which will inevitably lead to an increase in drug residues in meat, eggs, and milk. Also can cause toxic and side effects to strengthen because of the substantial increase of dosage, harm the health of sick livestock and poultry. [0003] Enrofloxacin is a quinolone veterinary drug. Its bactericidal mechanism is to enter the nucleus of pathogenic bacteria and interfere with DNA replication. It is ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/02A61K31/496A61K31/43A61K31/546A61P31/04
CPCA61K9/08A61K9/0019A61K47/02A61K31/496A61K31/43A61K31/546A61P31/04A61K2300/00Y02A40/70
Inventor 庞永中庞燕庞雁陈文欣
Owner 庞燕
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