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Antibacterial coating with pH monitoring function, functional material of antibacterial coating with pH monitoring function and preparation method thereof

A technology of antibacterial coating and functional materials, applied in the fields of botanical equipment and methods, chemicals for biological control, biocides, etc. problems to achieve a strong bonding effect

Pending Publication Date: 2020-01-10
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This traditional operation method that separates the use, sampling, and monitoring of materials usually has a certain time lag and cannot reflect the working status of materials in clinical applications in real time, resulting in delays in disposal
For a simple bacterial monitoring surface, even if convenient information transmission can be achieved, the lack of antibacterial function will still cause medical device infection, or the material itself cannot control the development of infection in the first place

Method used

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  • Antibacterial coating with pH monitoring function, functional material of antibacterial coating with pH monitoring function and preparation method thereof
  • Antibacterial coating with pH monitoring function, functional material of antibacterial coating with pH monitoring function and preparation method thereof
  • Antibacterial coating with pH monitoring function, functional material of antibacterial coating with pH monitoring function and preparation method thereof

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preparation example Construction

[0091] The present invention also provides a kind of preparation method of the antibacterial coating with pH monitoring function, comprises the following steps:

[0092] 1) After mixing 8-hydroxyl-1,3,6-pyrenetrisulfonic acid trisodium salt with a hydrogen-absorbing quaternary ammonium salt solution having a structure of formula (I), a hydrogen-absorbing quaternary ammonium salt / pyranine complex solution is obtained ;

[0093]

[0094] Among them, R 1 and R 2 each independently selected from -CH 3 、-CH 2 CH 3 ;

[0095] R 3 Alkyl group selected from C6~C18;

[0096] 2) After the hydrogen-absorbing quaternary ammonium salt / pyranine complex solution obtained in the above steps is cured by ultraviolet light, an antibacterial coating with a pH monitoring function is obtained.

[0097] The present invention compares the structure, material and specific parameters of the compound in the above preparation method, specific process parameters, and corresponding optimization ...

Embodiment 1

[0126] Preparation of Antibacterial Compounds with pH Monitoring Function and Coating Sample Surfaces

[0127] A) dissolving pyranine in ultrapure water to prepare a pyranine solution with a concentration of 0.025mmol / ml; N-(4-benzoylbenzyl)-N,N-dimethyldodecyl-1- Ammonium bromide was dissolved in ultrapure water to prepare a hydrogen pumping quaternary ammonium salt solution with a concentration of 0.075mmol / ml; the above 20mL pyranine solution was added dropwise to 20ml of N-(4-benzoylbenzyl) -N,N-Dimethyldodecyl-1-ammonium bromide solution. Mix and stir until precipitation occurs, centrifuge and wash the N-(4-benzoylbenzyl)-N,N-dimethyldodecyl-1-ammonium bromide / pyranine complex. After the complex was washed with ultrapure water, it was dried.

[0128] B) Dissolving the N-(4-benzoylbenzyl)-N,N-dimethyldodecyl-1-ammonium bromide / pyranine complex in ethanol to prepare 0.5g / ml of complex solution; the polymer sample is immersed in the above complex solution, and the solven...

Embodiment 2

[0131] A) dissolving pyranine in ultrapure water to prepare a pyranine solution with a concentration of 0.025mmol / ml; N-(4-benzoylbenzyl)-N,N-dimethyldodecyl-1- Ammonium bromide was dissolved in ultrapure water to prepare a hydrogen pumping quaternary ammonium salt solution with a concentration of 0.0725mmol / ml; the above 20mL pyranine solution was added dropwise to 20ml of N-(4-benzoylbenzyl) -N,N-Dimethyldodecyl-1-ammonium bromide solution. Mix and stir until precipitation occurs, centrifuge and wash the N-(4-benzoylbenzyl)-N,N-dimethyldodecyl-1-ammonium bromide / pyranine complex. After the complex was washed with ultrapure water, it was dried.

[0132] B) Dissolving the N-(4-benzoylbenzyl)-N,N-dimethyldodecyl-1-ammonium bromide / pyranine complex in ethanol to prepare 0.5g / ml of complex solution; the polymer sample is immersed in the above complex solution, and the solvent is evaporated at room temperature to obtain the loaded N-(4-benzoylbenzyl)-N,N-dimethyldodecyl-1 - Sa...

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Abstract

The invention provides an antibacterial coating with pH monitoring function. The antibacterial coating comprises a hydrogen abstraction type quaternary ammonium salt pyranine compound, which is obtained by reaction of trisodium 8-hydroxy-1, 3, 6-pyrene trisulfonate with the hydrogen abstraction type quaternary ammonium salt; and the hydrogen abstraction type quaternary ammonium salt has a structure shown as formula (I). A benzophenone functional group in the hydrogen abstraction type quaternary ammonium salt in the coating can undergo chemical bonding with a substrate material molecule, Pyranine and a hydrophobic alkyl chain, the inside of the coating undergoes mutual cross-linking to form a three-dimensional network structure, the self-stability of the coating can be improved, meanwhile,the coating and a coated substrate realize chemical bond cross-linking, so that the stability of the coating and the coated substrate is greatly improved, and the pH monitoring and antibacterial effect can be more durable. The method provided by the invention adopts an ultraviolet curing mode to form the coating, and has the characteristics of simple process, easy operation, and high feasibility.

Description

technical field [0001] The invention belongs to the field of antibacterial medical devices, and relates to an antibacterial coating with pH monitoring function, a functional material of the antibacterial coating with pH monitoring function and a preparation method thereof, in particular to an antibacterial coating with pH monitoring function, Antibacterial coating medical material with pH monitoring function and preparation method thereof. Background technique [0002] Nosocomial infection not only significantly increases the morbidity and mortality of patients, but also causes heavy economic losses to patients and the society, and poses a serious challenge to the global medical and health undertakings. According to statistics, the additional case fatality rate caused by nosocomial infection is 4% to 33%. About 720,000 nosocomial infections occur in the United States every year, resulting in about 75,000 deaths and increasing medical expenses by about 4.5 billion to 11 bill...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/18A01N25/10A01N35/04A01N33/12A01P1/00C08L23/06C08L23/12C08L27/06C08L69/00C08L75/04C08L25/06C08L77/00C08L33/12C08L83/04
CPCC08J7/18A01N25/10A01N35/04A01N33/12C08J2323/06C08J2323/12C08J2327/06C08J2369/00C08J2375/04C08J2325/06C08J2377/00C08J2333/12C08J2383/04
Inventor 闫顺杰周容涛栾世方殷敬华杨华伟张帅朱雪真孙振龙万雪刘应福
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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