A kind of preparation method of oteracil potassium

Abstract

The invention provides a preparation method of oteracil potassium. The method comprises the steps of: dissolving allantoin, alkali and potassium iodide in purified water at room temperature, adding N-halogenated amides in batches after the reaction solution is cooled, and heating up the reaction after the addition is completed. After the reaction is detected, the reaction solution is Lower the temperature, adjust the pH with acid, stir and grow the crystal, and filter with suction. The filter cake is washed with cold purified water until it is colorless, then rinsed with cold anhydrous alcohol solvent, and dried in vacuum to obtain oteracil potassium. Compared with the prior art, the whole process has simple and easy raw materials, easy operation, mild reaction conditions, stable quality, high yield, no pollution to the environment, and is suitable for industrialized production.

Description

A kind of preparation method of oteracil potassium technical field The invention belongs to the technical field of medicinal chemistry, be specifically related to a kind of preparation method of oteracil potassium. Background technique Compound that the present invention relates to is oteracil potassium (Potassium oxonate), has another name called potassium oxonate, chemical Name: 1,4,5,6-tetrahydro-4,6-dioxy-1,3,5-triazine-2-potassium carboxylate, chemical structural formula is as follows: [0003] Oteracil potassium is one of three kinds of active medicines in oral anticancer compound medicine Sigirone Capsules, Seggio Capsules It is an oral anticancer agent of fluorouracil derivatives, mainly composed of tegafur and two biochemical regulators, gimeracil and oteracil. It is composed of western potassium, among which tegafur has excellent oral bioavailability and can be converted into 5-fluorouracil in the body; gimeracil It can inhibit the degradation of 5-fluoro...

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Problems solved by technology

[0015] Aiming at the problems of low conversion rate, long reaction time, many impurities and low operation safety existing in the current preparation process, the present invention aims to provide a method with simple operation, mild reaction conditions, high product yield and high purity. A preparation method suitable for industrialized production of oteracil potassium with less pollution

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