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Traditional Chinese medicine composition and external patch for resolving depression, calming heart and soothing nerves and preparation method of external patch

The technology of a composition and traditional Chinese medicine is applied in the field of preparation of traditional Chinese medicine compositions and external patches, which can solve the problems of toxic and side effects, dependence and drug resistance, rebound insomnia and the like, and achieve the effect of remarkable curative effect and easy to obtain.

Inactive Publication Date: 2019-12-31
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of this type of western medicine is prone to toxic and side effects, dependence and drug resistance, and rebound insomnia occurs after stopping the medicine

Method used

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  • Traditional Chinese medicine composition and external patch for resolving depression, calming heart and soothing nerves and preparation method of external patch
  • Traditional Chinese medicine composition and external patch for resolving depression, calming heart and soothing nerves and preparation method of external patch
  • Traditional Chinese medicine composition and external patch for resolving depression, calming heart and soothing nerves and preparation method of external patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The proportions of lavender, geranium, calamus, rose, valerian, and lime blossom were screened, and the drug components were screened based on the extraction amount and extraction rate of volatile oil. The results are shown in the table below. The results show that the components in the prescription are compatible. The extraction rate of volatile oil is higher, indicating that the volatile oil in Jieyu Ningxin Anshen Formula formed after the compatibility of all parties has a similar and compatible solubilizing effect.

[0025] Table 1 Extraction effect table of different prescription volatile oils

[0026]

[0027] Note: Extraction rate of volatile oil = extraction amount of volatile oil / absolute content of volatile oil * 100%

[0028] The absolute content of the volatile oil extraction rate of the purchased medicinal materials is: 1.0% of lavender, 0.1% of geranium, 1.27% of calamus, 0.02% of rose, 0.75% of valerian, and 0.008% of lime flower.

[0029] The metho...

Embodiment 2

[0033] The screening research of the traditional Chinese medicine composition Jieyu Ningxin Anshen prescription: the composition and effect of Jieyu Ningxin Anshen prescription were investigated by mouse tail suspension test and forced swimming test, and the effects of each prescription on mouse autonomic activity (open field method) and threshold Effects of upper doses of pentobarbital sodium on sleep time of mice The sedative and hypnotic effects of various prescriptions of Jieyu Ningxin Anshen were investigated, and mice in all groups participated in the experiment.

[0034] 1. Antidepressant experiment

[0035] 1) Test substance: Take the medicine extracted in Example 1 (Table 1) as the test substance, rose as group 1, sour orange flower as group 2, sour orange flower, valerian, rose (1:0.15: 1) For group 3, lime blossom, valerian, calamus, rose (1:0.15:0.1:1) for group 4, lime blossom, geranium, calamus, rose, valerian (1:0.25: 0.1:1:0.15) is group 5, lime blossom, geran...

Embodiment 3

[0078] Further confirmation research on the efficacy of the prescription of the traditional Chinese medicine composition: the antidepressant effect of different dosage groups of Jieyu Ningxin Anshen prescription was investigated through the study of mouse tail suspension test and forced swimming experiment, and the effect of different dosage groups on the autonomous activity of mice (open field method) was investigated. ) and on the sleep time of mice induced by suprathreshold dose of pentobarbital sodium to investigate its sedative and hypnotic effect, and all groups of mice participated in the experiment.

[0079] 1. Experimental materials

[0080] 1) Experimental animals

[0081]Healthy Kunming mice, male, 18-22g. Experimental animals were purchased from the Animal Center of Jiangxi University of Traditional Chinese Medicine (permit number: SCXK (Gan) 2018-0003).

[0082] 2) test drug

[0083] Tween 80 (Xilong Chemical Co., Ltd.); Jieyu Anshen Granules (Shenwei Pharmaceu...

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Abstract

The invention discloses a traditional Chinese medicine composition and an external patch for resolving depression, calming the heart and soothing nerves and a preparation method of the external patch.The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 45-60 parts of citrus aurantium, 12-15 parts of geranium, 5-6 parts of rhizoma acori graminei, 45-60 parts of rose, 6-9 parts of valerian and 6-9 parts of lavender. Volatile oil of the citrus aurantium, the geranium, the rhizoma acori graminei, the rose, the valerian and the lavender is extracted by adopting a steam distillation method, water decoctions are collected, and the water decoctions of the six medicines are concentrated to be equivalent to 1g x mL<-1> of raw medicinal materials; and the volatile oil is prepared into micro-emulsion from hydrogenated castor oil 0040-polyethylene glycol-40, Tween 80, glyceryl monocaprylate, absolute ethyl alcohol and double distilled water, and auxiliary materials are added to obtain the patch for resolving depression, calming the heart and soothing nerves. Natural medicinal materials are adopted, are easy to obtain, and have small toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of gel plasters, in particular to a preparation method of a traditional Chinese medicine composition with the functions of relieving stagnation, calming the heart and tranquilizing the nerves, and an external patch. Background technique [0002] Insomnia is characterized by insomnia, which is called "insomnia" in traditional Chinese medicine, also known as "not sleeping", "not lying down" and "not dimming". Sleeping soundly, severe one can't sleep all night etc. Insomnia has become a social public health problem of widespread concern in many countries because of its high incidence and severe daytime function decline. With the acceleration of the pace of life in modern society and the continuous improvement of people's life pressure, people's average sleep time is significantly shortened. According to the World Health Organization, nearly a quarter of people in the world suffer from insomnia, which seriously...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K9/70A61P25/20A61P25/24
CPCA61K9/7061A61K36/185A61K36/53A61K36/738A61K36/752A61K36/84A61K36/888A61K2236/331A61P25/20A61P25/24A61K2300/00
Inventor 管咏梅陈丽华朱卫丰藏振中刘佳金晨杜清
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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