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Detection method of positive ion content in leonurus heterophyllus injection

A cation and injection technology, which is applied in the direction of measuring devices, material analysis by electromagnetic means, instruments, etc., can solve the problems of hidden dangers in the use of injections, hypercalcemia, and the inability to detect calcium and magnesium ions, etc., to achieve simple operation, Accurate results and guaranteed safety

Inactive Publication Date: 2019-12-27
CHENGDU FIRST PHARMACEDTICAL CO LTD
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Problems solved by technology

[0002] Chinese medicine injection is an original new dosage form in my country. Its appearance has changed the traditional way of administering Chinese medicine. Its research and development has become one of the hot spots in the modernization of Chinese medicine. Therefore, the safety of traditional Chinese medicine injections has always been the focus of attention at home and abroad
It has been reported that HPLC-ELSD method was used to establish the fingerprint of motherwort injection. It can only measure potassium and sodium cations in the injection, but cannot detect calcium and magnesium ions. If the calcium and magnesium in the injection exceed the standard, it will lead to hypercalcemia and hypermagnesemia. This method cannot comprehensively detect cations, giving The use of injections brings great hidden dangers

Method used

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  • Detection method of positive ion content in leonurus heterophyllus injection
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  • Detection method of positive ion content in leonurus heterophyllus injection

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Embodiment 1

[0028] Embodiment 1, cationic detection in motherwort injection of the present invention

[0029] (1) Establishment of positive ion standard curve

[0030] a. Preparation of reference substance solution:

[0031] Take Na, Mg, K, Ca standard solution, add 2% nitric acid solution (containing 200ng / ml Au) to dilute to a stock solution with a concentration of 100000ng / ml, and add 2% nitric acid solution (containing 200ng / ml Au) to the stock solution Stepwise dilution into a series of concentrations (5ng / ml, 10ng / ml, 20ng / ml, 50ng / ml, 80ng / ml, 100ng / ml, 200ng / ml, 400ng / ml);

[0032] b, internal standard solution preparation: take Ge standard solution, add 2% nitric acid solution (containing 200ng / ml Au) and dilute into 500ng / ml internal standard solution;

[0033] c. Determination of reference substance solution:

[0034] Take a series of concentration reference substance solutions and inject them into the ICP-MS instrument for detection, and at the same time use a peristaltic p...

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Abstract

The invention discloses a detection method of positive ion content in a leonurus heterophyllus injection. The detection method comprises the steps of (1) establishment of a positive ion standard curve; and (2) determination of the positive ion content in a to-be-detected sample, wherein a test solution and a blank solution are taken and injected into an ICP-MS (inductively coupled plasma-mass spectrometer) for detection, and the positive ion content in the to-be-detected sample is obtained according to the standard curve. Through the detection method of the positive ion content in the leonurusheterophyllus injection, sodium ions, potassium ions, calcium ions and magnesium ions in the leonurus heterophyllus injection can be determined simultaneously, the sample does not need pretreatment,operation is easy and convenient, the result is accurate, the positive ions in the leonurus heterophyllus injection can be effectively controlled, and therefore the safety of the leonurus heterophyllus injection is guaranteed.

Description

technical field [0001] The invention specifically relates to a method for detecting cation content in motherwort injection. Background technique [0002] Chinese medicine injection is an original new dosage form in my country. Its appearance has changed the traditional way of administering Chinese medicine. Its research and development has become one of the hot spots in the modernization of Chinese medicine. Therefore, the safety of traditional Chinese medicine injections has always been the focus of attention at home and abroad. In recent years, with the development of traditional Chinese medicine injections and their more and more clinical applications, the reports of related adverse reactions have gradually increased, among which the detection and limit control of trace elements are very important. The main trace elements potassium, calcium, magnesium and sodium in the human body, as an important part of the material basis of drug properties, are closely related to the dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62G01N27/626
CPCG01N27/62
Inventor 刘昭华江燕史平伍
Owner CHENGDU FIRST PHARMACEDTICAL CO LTD
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