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Surgical implant material for muscle mechanics-assisted repair, and preparation method thereof

A surgical implantation and mechanics technology, applied in medical science, coating, prosthesis, etc., can solve problems such as poor compatibility, achieve good fusion, reduce bleeding and inflammatory reactions, and overcome high material waste.

Inactive Publication Date: 2019-12-20
PKU HKUST SHENZHEN HONGKONG INSTITUTION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application found that the material still has disadvantages such as poor compatibility with tissues.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A method for preparing the above-mentioned surgical implant material for assisted repair of muscle mechanics is implemented according to the following steps:

[0016] Step 1: dissolving the collagen in acetic acid to obtain an acetic acid solution whose mass percent concentration of collagen is 3%;

[0017] Step 2: Put the reticular bacterial cellulose substrate material that was treated with endotoxin removal and purification according to the method of patent application 201810180455.4 into the collagen acetic acid solution prepared in step 1, use a Votex-genie 2 vortex oscillator, and adjust To the 8th gear, after 10 minutes of vortex treatment, hang the material to dry at room temperature;

[0018] Step 3: Put the base material prepared in step 2 into an aqueous solution of glutaraldehyde with a mass percent concentration of 3%, and then add 0.02% Al to the solution 2 (SO4) 3 , at 37 o C and rotating speed is to soak 60 minutes in the shaker of 110rmp;

[0019] S...

Embodiment 2

[0021] The material of the above-mentioned Example 1, the bacterial cellulose base material (comparative example 1) and the bacterial cellulose surgical implant material coated with collagen on the surface (comparative example 2) prepared by the prior art were respectively tested for nitrogen atom content and surface roughness of the material Degree measurement, the results are shown in Table 1.

[0022] Table 1

[0023] sample Atomic content of nitrogen % RMS surface roughness nm Comparative example 1 0 27.5 Comparative example 2 1.7 75.6 Example 1 5.56 45.7

[0024] Show from above-mentioned measurement result, the material of present embodiment 1 compares the material of comparative example 2, can make bacterial cellulose contain more collagen that can improve biocompatibility (because only nitrogen is contained in collagen, so the content of nitrogen element It reflects the content of collagen), and at the same time, the surface roug...

Embodiment 3

[0026] The method for preparing the surgical implant material for muscle mechanics assisted repair by the method substantially the same as that of Example 1 has the following differences:

[0027] 1. Vortex for 30 seconds;

[0028] 2. The concentration of the aqueous solution of glutaraldehyde is 10%, and the soaking time is 50 minutes at 48oC and magnetic stirring;

[0029] 3. Under the vacuum environment of 0.5Mpa, soak the base material in the third step for 60 o C, react for 10 minutes.

[0030] After testing, the content of nitrogen atoms in the above-mentioned surgical implant material is 14.89%, and the root mean square surface roughness of the material is 42.6nm according to the surface roughness measurement.

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Abstract

The present invention provides a surgical implant material for muscle mechanics-assisted repair, and a preparation method thereof. A reticular bacterial cellulose substrate material contains a collagen compound; the bacterial cellulose substrate material is put into a collagen solution and treated by a vortex oscillation mode, and drying at normal temperature is conducted; and then the material issoaked in an aqueous solution of an aldehyde compound to react for 10-30 min under a vacuum environment to prepare the surgical implant material for the muscle mechanics-assisted repair. The surgicalimplant material can effectively improve biocompatibility, can also maintain soft, smooth and conformable properties of the substrate material to reduce friction-induced damages to surrounding tissues, and thus reduces bleeding and inflammatory reactions. Meanwhile, the preparation method is more reasonable and convenient in process condition control and more suitable for industrial production expansion.

Description

technical field [0001] The invention relates to a medical surgical material and a preparation method, in particular to a surgical implant material and a preparation method for muscle mechanics auxiliary repair. Background technique [0002] Pelvic support comes from the muscular connective tissue (fascia) of the pelvic floor, as well as the thickened portion of the ligaments. However, as women age, the pelvic floor muscles gradually relax. When the fascia and ligaments cannot bear the corresponding weight, the pelvic organs will descend and enter the vaginal wall, causing female pelvic floor dysfunction such as urinary incontinence and uterine prolapse. Diseases, the incidence rate is as high as 40-60% in middle-aged and elderly women. Surgical implantation of the corresponding material is the only effective treatment. The surgical implant materials currently used clinically are all imported and mainly concentrated in European and American countries, such as Johnson & John...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/34A61L27/50
CPCA61L27/20A61L27/34A61L27/50A61L2420/02A61L2430/30C08L1/02C08L89/00A61L27/24A61L27/48A61F2/0063A61F2002/0081A61F2240/001A61L27/3637A61L27/3687
Inventor 赖琛奚廷斐盛立远
Owner PKU HKUST SHENZHEN HONGKONG INSTITUTION
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