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Antibacterial caries-preventing composition as well as preparation method and application thereof

A composition and an anti-caries technology, applied in the field of daily chemicals, can solve the problems of limiting the antibacterial and anti-caries effects of polydopamine particles, easy aggregation of polydopamine particles, limited antibacterial ability, etc., avoiding toxic side effects and enhancing the anti-caries effect. , The effect of strengthening the prevention of periodontal disease

Active Publication Date: 2019-12-13
CHONGQING DENCARE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are following defects in the scheme of prior art: (1) use polydopamine particle alone, the antibacterial ability to common bacteria (as Streptococcus mutans and Porphyromonas gingivalis) in oral environment is limited; (2) polydopamine particle is easy Aggregation prevents polydopamine particles from evenly attaching to the tooth surface, hinders its application in the oral environment, and limits the antibacterial and anti-caries effects of polydopamine particles

Method used

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  • Antibacterial caries-preventing composition as well as preparation method and application thereof
  • Antibacterial caries-preventing composition as well as preparation method and application thereof
  • Antibacterial caries-preventing composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0055] Toothpaste is prepared as follows:

[0056] (1) Use polyethylene glycol to dissolve the polydopamine granules, then add the remaining moisturizing agent, then add the thickener, after stirring homogeneously, add flavoring agent, polyphosphate, surfactant and water in turn, and stir evenly, Obtain mixture A;

[0057] (2) Add friction agent to mixture A, vacuumize the container holding mixture A, stir mixture A and friction agent evenly, and obtain mixture B;

[0058] (3) Add essence to homogeneous mixture B, stir to homogenize, and get toothpaste after degassing.

[0059] The concrete formula of toothpaste in embodiment 8-embodiment 17 is as shown in table 2.

[0060] Table 2: Parameter information in embodiment 7-embodiment 16

[0061]

[0062] The specific preparation method of toothpaste in embodiment 8-embodiment 17 is: add polyethylene glycol to dissolve polydopamine particle in the paste making machine, then add sodium carboxymethyl cellulose and glycerin, st...

experiment example 1

[0063] Experimental Example 1: Fractional Inhibitory Concentration (FIC)

[0064] Polydopamine particles containing different concentrations and polyphosphate were mixed and dissolved in the agar medium by the agar dilution method, and then the tested bacteria passed the bacterial growth or not to determine the minimum antibacterial (inhibitory) substances inhibiting the growth of the tested bacteria. Inhibitory concentration (MIC value).

[0065] According to the MIC of the two substances alone and in combination, the FIC index (MIC A药联用 / MIC A药单用 +MIC B药联用 / MIC B药单用 ). When the FIC index≤0.75, it indicates that the two have a synergistic effect; when 0.75

[0066] The MIC values ​​of polydopamine particles and polyphosphate and the FIC index after the combination of the two are shown in Table 3-Table 7.

[0067] Table 3: Experimental results of the ...

experiment example 2

[0078] Experimental example 2: Toothpaste antibacterial test

[0079] 1. Obtaining toothpaste samples

[0080] In order to verify the antibacterial and anti-caries effect of the toothpaste of the present invention, the toothpaste (group 2 in Table 8) that does not add polydopamine particles and only polyphosphate was prepared, and the toothpaste (in Table 8) that added polydopamine particles and polyphosphate 4 groups), and the contrast of two kinds of toothpastes (group 1 and group 3 in table 8), the specific formula is shown in table 8.

[0081] Table 8: In Experimental Example 2, the formulation information of Group 1-4

[0082]

[0083] To four groups of toothpastes shown in table 8, according to Ministry of Public Health 2002 edition " disinfection technical specification " (2.1.8.3) minimum inhibitory concentration test method, adopt the agar dilution method to be mixed with four groups of toothpastes containing above-mentioned table 8 of different concentrations Di...

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Abstract

The invention belongs to the field of daily chemical products, and relates to a composition for oral cavity supplies as well as a preparation method and application thereof, in particular to an antibacterial caries-preventing composition as well as a preparation method and application thereof. The antibacterial caries-preventing composition is prepared from polydopamine granules and polyphosphate;based on an effect of suppressing common bacteria in an oral cavity environment, the two substances have a synergistic effect, and thus, the antibacterial caries-preventing composition which is prepared from polydopamine granules and polyphosphate has a better effect on both prevention of periodontal diseases and caries diseases. The antibacterial caries-preventing composition can be applied to research and development as well as production of toothpastes, liquid toothpastes, mouthwash, dental powder, tooth gel or gum.

Description

technical field [0001] The invention belongs to the field of daily chemicals, and relates to a composition for oral products and its preparation method and application, in particular to an antibacterial and anti-caries composition, its preparation method and application. Background technique [0002] Dopamine (4-(2-ethylamino)benzene-1,2-diol) is a typical catechol-based derivative that can self-polymerize under alkaline conditions to form polydopamine particles. There are a large number of active groups such as phenolic hydroxyl groups and amino groups on the surface and inside the structure of polydopamine particles, so they have excellent surface activity. Polydopamine particles are rich in reducing functional groups such as catechol and imine, and have certain antioxidant activity, which can effectively inhibit periodontal disease (including oxidative stress periodontal disease) caused by excessive active oxygen. The polydopamine granules themselves also have antibacter...

Claims

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Application Information

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IPC IPC(8): A61K8/84A61K8/24A61Q11/00A61P1/02A61P31/02
CPCA61K8/84A61K8/24A61Q11/00A61P1/02A61P31/02Y02A50/30
Inventor 尹丽娟张环邓全富唐伟月陆瑜邓嵘邱琳
Owner CHONGQING DENCARE CORP
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