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Hantavirus (HTV) long-peptide vaccine

A technology of Hantavirus and virus antigen, applied in the field of long peptide vaccine of Hantavirus, can solve the problems of weakening the immune effect of the vaccine, and achieve the effects of simple and easy preparation method, strong immunogenicity and high safety

Pending Publication Date: 2019-12-10
王美亮
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, certain components in inactivated virus vaccines or viral structural protein subunit vaccines may induce pathological T cell responses in the body, thereby weakening the immune effect of the vaccine

Method used

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  • Hantavirus (HTV) long-peptide vaccine
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  • Hantavirus (HTV) long-peptide vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0029] Example. Immunogenicity of HTNV long peptide compositions

[0030] 1. Materials and Methods

[0031] 1.1 Mice: BALB / c mice aged 6–8 weeks were purchased from the Animal Experiment Center of Lanzhou General Hospital of Lanzhou Military Region.

[0032]1.2 Peptides: According to the N nucleoprotein and Gn / Gc glycoprotein sequences of HTNV 76-118 strain, SEOV R22 strain, and DOBV Slo / Af-BER strain, as well as the immunodominant regions with dense T and B cell epitopes published in the literature, design and Synthetic HTNV long peptide was used as the antigenic component of the vaccine. N nucleoprotein is the most conserved structural protein in HTV, and it is also the main target for virus-specific T cell recognition. Its T cell epitope is mainly located in the 115–429 region of N nucleoprotein. In summary, 17 peptides covering the region of HTNV N110–429 were designed, including HTNV N110–136, HTNV N124–158, HTNV N144–169, HTNV N155–189, HTNV N175–200, HTNV N191–225 , ...

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Abstract

The invention relates to immunogenic long peptides derived from hantavirus (HTV), or a long-peptide composition, provides a method for inducing or enhancing HTV specific immune response, and further relates to a vaccine and method used for preventing and / or treating HTV-related diseases, wherein the vaccine includes the peptides.

Description

technical field [0001] The invention belongs to the technical field of vaccinology and antiviral immunology, and specifically relates to a long peptide vaccine of hantavirus and its preventive and therapeutic application in hantavirus-related diseases or infections. Background technique [0002] Hantavirus (HTV) can cause two acute febrile diseases in humans: hemorrhagic fever with renal syndrome (HFRS) and Hantavirus pulmonary syndrome (HPS). HFRS is mainly prevalent in Eurasia, composed of Hantaan virus (HTNV), Puumala virus (PUUV), Dobrava-Belgrade virus (Dobrava-Belgradevirus, DOBV) and Seoul virus (Seoul virus). , SEOV) and so on. Sin Nombre virus (SNV) and Andes virus (Andes viruses, ANDV) mainly cause HPS in the American continent. In China, HFRS is mainly caused by HTNV and SEOV, and HFRS caused by HTNV is more severe and has a higher mortality rate. [0003] At present, the HFRS vaccines marketed at home and abroad are all inactivated virus vaccines, including mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12A61P31/14A61P37/04
CPCA61K39/12A61P31/14A61P37/04C12N2760/12034A61K2039/57
Inventor 王美亮郭谌予柴三明杨霄鹏马俊张富婷惠玲
Owner 王美亮
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