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Croton crassifolius root extract, and supercutical fluid extraction method and application thereof

An extraction method and extraction technology, applied in the field of chicken bone vetch root extract and its supercritical fluid extraction, can solve the problems of less research and achieve high anti-tumor activity, anti-proliferation cell apoptosis, and induction of cell apoptosis Effect

Active Publication Date: 2019-12-06
INST OF AGRO FOOD SCI & TECH SHANDONG ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, it is reported that the low polar part of the herb is rich in active compounds, but there are few specific studies
There is no relevant record about the extraction of the compound of the present invention

Method used

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  • Croton crassifolius root extract, and supercutical fluid extraction method and application thereof
  • Croton crassifolius root extract, and supercutical fluid extraction method and application thereof
  • Croton crassifolius root extract, and supercutical fluid extraction method and application thereof

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Embodiment 1

[0029] (1) Materials and methods

[0030] Crassifolius The roots were purchased at a Chinese herbal medicine market in Bozhou, Anhui, China, in October 2017. This species was identified by Prof. Shan Chenggang, Institute of Agricultural Food Science and Technology, Shandong Academy of Agricultural Sciences (IAST, SAAS), Jinan, China. Voucher samples (No.17-10-29) are kept at the IAST Bioactive Substances and Functional Foods Laboratory at SAAS.

[0031] (2) Extraction process:

[0032] Take the dried root of Jiguxiang, pulverize it with a traditional Chinese medicine grinder, and pass through a 40-mesh sieve (450 μm). Weigh 2.0 kg of sample and fill it with supercritical CO in 10 times 2 In the reaction vessel (650 mL) of the fluid extractor, 200 g each time. At 25 MPa, 35 o C under static extraction for 30 minutes, followed by dynamic extraction for 30 minutes (CO 2 Flow rate 5.0 L / min), with methanol as entrainer (flow rate 5.4 mL / min). A total of 100.4 g of dark ...

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Abstract

The invention belongs to the technical field of medicine extraction, and particularly relates to a Croton crassifolius root extract, and a supercutical fluid extraction method and application thereof.The structural formula of the extract is as shown in the specification. The extract prepared in the invention is prepared from readily available medicinal raw materials, has high purity and high antitumor activity, can resist proliferation and induce apoptosis, shows the potential of serving as an anticancer therapy candidate, is easy to industrialize, can be prepared into different dosage formsas required, and produces huge social benefits.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction, and in particular relates to a chicken bone radix extract and a supercritical fluid extraction method and application thereof. Background technique [0002] Croton is a large genus of Euphorbiaceae with more than 1300 species widely distributed in tropical and subtropical regions. There are about 21 species of jiguxiang grown in China, some of which have long been used to relieve dysmenorrhea and traditional Chinese medicine to treat indigestion and malaria. Plants of the Croton genus are known for their variety of terpenoids with a wide range of biological activities. In addition, alkaloids, flavanones, lignans, polyphenolic compounds, phenylbutyric acid and peptides were obtained. [0003] Croton crassifolius Geisel is a species of Croton, mainly distributed in southern China and other parts of Southeast Asia. As a Chinese medicinal herb called "Ji Gu Xiang", its root has been ...

Claims

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Application Information

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IPC IPC(8): C07D307/46A61P35/00
CPCC07D307/46A61P35/00Y02P20/54Y02A50/30
Inventor 孙金月刘超陈英凯程安玮王新坤王青
Owner INST OF AGRO FOOD SCI & TECH SHANDONG ACAD OF AGRI SCI
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