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Preparation method of nano-cellulose antibacterial hydrogel

A technology of nanocellulose and antibacterial water is applied in the field of preparation of nanocellulose antibacterial hydrogel, which can solve the problems of complex operation process, poor environmental friendliness, complex preparation process, etc., and achieves simple process, excellent antibacterial performance, and preparation process. simple effect

Active Publication Date: 2019-11-22
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of this kind of nanocellulose hydrogel is relatively complicated, and the synthetic hydrophilic polymer is often used as the main body of the gel, which is not environmentally friendly.
In addition, using existing preparation methods to endow nanocellulose hydrogel with antibacterial function often requires additional mixing or loading of antibacterial agents, and the operation process is complicated.
However, there is no report on the preparation of nanocellulose antibacterial hydrogels using polyhexamethyleneguanidine hydrochloride with antibacterial function as a crosslinking agent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of nanocellulose antibacterial hydrogel, comprising the steps of:

[0020] (1) Preparation of TEMPO oxidized nanocellulose colloid: adopt TEMPO oxidation method to pretreat the nanocellulose obtained after mechanical grinding of bleached coniferous wood fibers, and obtain TEMPO oxidized nanocellulose whose surface carboxyl content is 600mmol / Kg, and then Concentrate to a mass concentration of 3% by solvent evaporation, and degas in a vacuum to obtain TEMPO oxidized nanocellulose colloid;

[0021] (2) Preparation of polyhexamethyleneguanidine hydrochloride aqueous solution: polyhexamethyleneguanidine hydrochloride powder (molecular weight is 500) is dissolved in distilled water, the consumption of polyhexamethyleneguanidine hydrochloride and distilled water is by weight The proportioning ratio is 2:98, and after dissolving, a polyhexamethyleneguanidine hydrochloride aqueous solution with a mass concentration of 2% is obtained;

[0022] (3) Gelation ...

Embodiment 2

[0025] A preparation method of nanocellulose antibacterial hydrogel, comprising the steps of:

[0026] (1) Preparation of TEMPO oxidized nanocellulose colloid: the TEMPO oxidized nanocellulose obtained by mechanically grinding the bleached broad-leaved wood fibers was pretreated by TEMPO oxidation to obtain TEMPO oxidized nanocellulose with a surface carboxyl content of 900mmol / Kg, and then Concentrate to a mass concentration of 3% by solvent evaporation, and degas in a vacuum to obtain TEMPO oxidized nanocellulose colloid;

[0027] (2) Preparation of polyhexamethyleneguanidine hydrochloride aqueous solution: polyhexamethyleneguanidine hydrochloride powder (molecular weight is 550) is dissolved in distilled water, the consumption of polyhexamethyleneguanidine hydrochloride and distilled water is by weight The proportioning ratio is 2:98, and after dissolving, a polyhexamethyleneguanidine hydrochloride aqueous solution with a mass concentration of 2% is obtained;

[0028] (3) ...

Embodiment 3

[0031] A preparation method of nanocellulose antibacterial hydrogel, comprising the steps of:

[0032] (1) Preparation of TEMPO oxidized nanocellulose colloid: the TEMPO oxidized nanocellulose with a surface carboxyl content of 1200mmol / Kg is obtained by pretreatment of the nanocellulose obtained by mechanically grinding the bleached bagasse fiber by using the TEMPO oxidation method, and then using a solvent Concentrate to a mass concentration of 3% by evaporation, and degas in a vacuum to obtain TEMPO oxidized nanocellulose colloid;

[0033] (2) Preparation of polyhexamethyleneguanidine hydrochloride aqueous solution: polyhexamethyleneguanidine hydrochloride powder (molecular weight is 600) is dissolved in distilled water, the consumption of polyhexamethyleneguanidine hydrochloride and distilled water is by weight The proportioning ratio is 2:98, and after dissolving, a polyhexamethyleneguanidine hydrochloride aqueous solution with a mass concentration of 2% is obtained;

[...

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PUM

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Abstract

The invention discloses a preparation method of nano cellulose antibacterial hydrogel. The method comprises the following steps: (1) preparing TEMPO oxidized nanocellulose colloid; (2) preparing a polyhexamethylene guanidine hydrochloride aqueous solution; and (3) placing the TEMPO oxidized nano-cellulose colloid into a polytetrafluoroethylene mold, dropwise adding a polyhexamethylene guanidine hydrochloride aqueous solution, performing standing treatment for 24-48 hours, and performing electrostatic adsorption coupling on the TEMPO oxidized nano-cellulose colloid and the polyhexamethylene guanidine hydrochloride aqueous solution to form the nano-cellulose antibacterial hydrogel. The method is simple in process and environmentally friendly in raw material, and the prepared nano-cellulose hydrogel has high strength and good antibacterial performance and is widely applied to the fields of drug loading, controllable release, chemical sensors and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of hydrogel materials and antibacterial materials, and in particular relates to a preparation method of nanocellulose antibacterial hydrogel. Background technique [0002] Hydrogel is a framework structure formed by physical or chemical cross-linking of polymers under certain conditions, and liquid water is dispersed and filled in the structural voids to form a three-dimensional network structure system that can be swollen by water but insoluble in water. Hydrogels formed by natural polymers such as cellulose, chitosan, sodium alginate, and starch have gradually been applied in fields such as agriculture, food, and tissue engineering because of their good biocompatibility and degradability. Among them, cellulose is a hydrophilic polymer polysaccharide composed of D-glucose groups, which is abundant in nature and naturally renewable. Nanocellulose prepared from cellulose has the characteristic...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L1/04C08L79/00C08B15/02
CPCC08J3/075C08B15/02C08J2301/04C08J2479/00C08J2401/04C08J2379/00
Inventor 吴敏刘仁鲁鹏郑璐王志伟
Owner GUANGXI UNIV
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