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Application of THBS1 cytokine in preparation of medicament for treating hepatic failure

A liver failure and cytokine technology, applied in the fields of molecular medicine, biomedicine, and clinical medicine, can solve the problems of death of patients and shortage of donor livers.

Inactive Publication Date: 2019-11-15
杭州笙源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But due to a severe shortage of donor livers, a large number of patients died while waiting for a liver transplant

Method used

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  • Application of THBS1 cytokine in preparation of medicament for treating hepatic failure
  • Application of THBS1 cytokine in preparation of medicament for treating hepatic failure
  • Application of THBS1 cytokine in preparation of medicament for treating hepatic failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: Injection containing THBS1 cytokines treats a large animal (young pig) model of liver failure

[0042] Animal model: 30 male Chinese young pigs (8-10 kg) were randomly divided into two groups, 15 in each group. Each young pig was injected with D-gal 1.5g / kg in the jugular vein to create a liver failure model.

[0043] Experimental group: Multiple intravenous injections of THBS1 injection at fixed time points after D-gal injection, dose: 10ml / kg, twice a day.

[0044] Control group: inject the same amount of normal saline without THBS1.

[0045] Neither the control group nor the experimental group received other drug treatment.

[0046] figure 1 It is a schematic diagram of the survival time curves of the young pigs of the experimental group and the control group, showing the survival rate of the young pigs of the experimental group and the control group. The results showed that the 3-day survival rate of young pigs in the treatment group containing THB...

Embodiment 2

[0047] Example 2: The small animal (rat) model of liver failure treated by freeze-dried powder injection containing THBS1 cytokine

[0048] Animal model: 100 male rats (200-250 g) were randomly divided into two groups, 50 in each group. Each rat was intraperitoneally injected with D-gal 1.5g / kg to make a liver failure model. THBS1 lyophilized powder and water for injection are prepared into a suspension.

[0049] Experimental group: intraperitoneal injection of THBS1 lyophilized powder suspension 4ml at a fixed time point after D-gal injection, twice a day.

[0050] Control group: inject the same amount of normal saline without THBS1.

[0051] Both the control group and the experimental group received no other drug treatment.

[0052] figure 2Schematic diagram of the survival time curves of rats in the experimental group and the control group, figure 2 The survival rate of the rats in the experimental group and the control group is shown: the results show that the 3-day...

Embodiment 3

[0053] Example 3: The suspension containing THBS1 cytokines treats the rabbit model of liver failure

[0054] Animal model: 40 adult male rabbits (2000-2500 g) were randomly divided into two groups, 20 in each group. Each rabbit was intramuscularly injected with D-gal 1.5g / kg to make a liver failure model.

[0055] Test group: intramuscularly inject 20 ml of THBS1 suspension at a fixed time point after D-gal injection, twice a day.

[0056] Control group: inject the same amount of normal saline without THBS1.

[0057] Both the control group and the experimental group received no other drug treatment.

[0058] image 3 It is a schematic diagram of the survival time curves of rabbits in the experimental group and the control group, image 3 The survival rate of the rabbits in the experimental group and the control group is shown: the results show that the survival rate of the rabbits in the THBS1 treatment group is 90% at 1 day, and 80% at 7 days, while the survival rate at ...

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Abstract

The invention discloses application of a THBS1 cytokine in preparation of a medicament for treating hepatic failure. The temperature for transport and storage of the THBS1 cytokine-containing medicament is 2-8 DEG C, the humidity is 45-75%, and the THBS1 is a member of an ABCA superfamily and is mainly used for mediating transmembrane transport of lipids. In the application of the THBS1 cytokine in preparation of the medicament for treating hepatic failure, the biochemical indexes of patients can be significantly improved, the bilirubin level is lowered, the transaminase is reduced, the bloodcoagulation function is improved, the albumin level is raised, hepatocyte death is inhibited, regeneration of hepatocytes and bile duct cells is promoted, fatal complications such as major upper gastrointestinal duct bleeding, severe hepatic encephalopathy and hepatorenal syndromes are prevented, the survival time is significantly prolonged, and the survival rate is increased.

Description

technical field [0001] The invention belongs to the fields of clinical medicine, molecular medicine and biomedicine, and is a new technology for treating liver failure with THBS1 cytokine series drugs, specifically, an application of THBS1 cytokine in the preparation of medicaments for treating liver failure. Background technique [0002] Liver failure is a kind of disease caused by extensive necrosis of the liver caused by various reasons. Except for orthotopic liver transplantation, there is currently no specific treatment. However, due to the severe shortage of donor livers, a large number of patients died while waiting for liver transplantation. Clarifying the pathogenesis of liver failure and early treatment targeting the mechanism can effectively block the progression of the disease and reduce the mortality rate, which is of great significance to the treatment of liver failure. Thrombin is a family of secreted multifunctional proteins consisting of thromboroadins 1-5...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61P1/16
CPCA61K38/19A61P1/16
Inventor 李君陈新李江辛娇娇
Owner 杭州笙源生物科技有限公司
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