Application of THBS1 cytokine in preparation of medicament for treating hepatic failure
A liver failure and cytokine technology, applied in the fields of molecular medicine, biomedicine, and clinical medicine, can solve the problems of death of patients and shortage of donor livers.
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Embodiment 1
[0041] Embodiment 1: Injection containing THBS1 cytokines treats a large animal (young pig) model of liver failure
[0042] Animal model: 30 male Chinese young pigs (8-10 kg) were randomly divided into two groups, 15 in each group. Each young pig was injected with D-gal 1.5g / kg in the jugular vein to create a liver failure model.
[0043] Experimental group: Multiple intravenous injections of THBS1 injection at fixed time points after D-gal injection, dose: 10ml / kg, twice a day.
[0044] Control group: inject the same amount of normal saline without THBS1.
[0045] Neither the control group nor the experimental group received other drug treatment.
[0046] figure 1 It is a schematic diagram of the survival time curves of the young pigs of the experimental group and the control group, showing the survival rate of the young pigs of the experimental group and the control group. The results showed that the 3-day survival rate of young pigs in the treatment group containing THB...
Embodiment 2
[0047] Example 2: The small animal (rat) model of liver failure treated by freeze-dried powder injection containing THBS1 cytokine
[0048] Animal model: 100 male rats (200-250 g) were randomly divided into two groups, 50 in each group. Each rat was intraperitoneally injected with D-gal 1.5g / kg to make a liver failure model. THBS1 lyophilized powder and water for injection are prepared into a suspension.
[0049] Experimental group: intraperitoneal injection of THBS1 lyophilized powder suspension 4ml at a fixed time point after D-gal injection, twice a day.
[0050] Control group: inject the same amount of normal saline without THBS1.
[0051] Both the control group and the experimental group received no other drug treatment.
[0052] figure 2Schematic diagram of the survival time curves of rats in the experimental group and the control group, figure 2 The survival rate of the rats in the experimental group and the control group is shown: the results show that the 3-day...
Embodiment 3
[0053] Example 3: The suspension containing THBS1 cytokines treats the rabbit model of liver failure
[0054] Animal model: 40 adult male rabbits (2000-2500 g) were randomly divided into two groups, 20 in each group. Each rabbit was intramuscularly injected with D-gal 1.5g / kg to make a liver failure model.
[0055] Test group: intramuscularly inject 20 ml of THBS1 suspension at a fixed time point after D-gal injection, twice a day.
[0056] Control group: inject the same amount of normal saline without THBS1.
[0057] Both the control group and the experimental group received no other drug treatment.
[0058] image 3 It is a schematic diagram of the survival time curves of rabbits in the experimental group and the control group, image 3 The survival rate of the rabbits in the experimental group and the control group is shown: the results show that the survival rate of the rabbits in the THBS1 treatment group is 90% at 1 day, and 80% at 7 days, while the survival rate at ...
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