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Preparation method of drug carrier hydrogel with high biocompatibility

A biocompatible, hydrogel technology, applied in the field of preparation of highly biocompatible drug carrier hydrogels, can solve the problems of low oral bioavailability, side effects, etc., and achieves improved in vivo degradation performance and mild reaction conditions , the effect of improving pH sensitivity and mechanical properties

Inactive Publication Date: 2019-10-29
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to poor dissolution in the stomach, INDs may exhibit low oral bioavailability due to prolonged contact with mucous membranes or may cause side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] First, add 0.5% carboxymethyl nanocellulose and 2% chitosan in sequence to 2% sodium alginate solution, use a high-speed disperser to disperse at a speed of 1000r / min, and disperse for 3 hours to carboxymethyl nanocellulose 1. Chitosan is evenly dispersed in sodium alginate solution to obtain sodium alginate-carboxymethyl nanocellulose-chitosan mixture; secondly, inject the obtained mixture into the mold and soak in 2mol / L hydrochloric acid solution Sodium alginate and chitosan were fully cross-linked for 24 hours; again, the composite hydrogel was soaked in 0.1mol / L sodium periodate solution, oxidized in a refrigerator at 4°C for 12 hours, and freeze-dried for later use; Finally, soak the oxidized and dried composite hydrogel in 0.4 g / ml indomethacin ammonia water for 12 hours, and dry to obtain the indomethacin-loaded composite hydrogel.

Embodiment 2

[0024] First, add 3.6% carboxymethyl nanocellulose and 15% chitosan in sequence to 10% sodium alginate solution, use a high-speed disperser to disperse at a speed of 1000r / min, and disperse for 4 hours to carboxymethyl nanocellulose 1. Chitosan is evenly dispersed in sodium alginate solution to obtain sodium alginate-carboxymethyl nanocellulose-chitosan mixture; secondly, inject the obtained mixture into the mold and soak in 2mol / L hydrochloric acid solution Sodium alginate and chitosan were fully cross-linked for 24 hours; again, the composite hydrogel was soaked in 0.1mol / L sodium periodate solution, oxidized in a refrigerator at 4°C for 12 hours, and freeze-dried for later use; Finally, soak the oxidized and dried composite hydrogel in 0.6 g / ml indomethacin ammonia water for 18 hours, and dry to obtain the indomethacin-loaded composite hydrogel.

Embodiment 3

[0026] First, add 5% carboxymethyl nanocellulose and 20% chitosan in sequence to 20% sodium alginate solution, use a high-speed disperser to disperse at a speed of 1000r / min, and disperse for 5 hours to carboxymethyl nanocellulose 1. Chitosan is evenly dispersed in sodium alginate solution to obtain sodium alginate-carboxymethyl nanocellulose-chitosan mixture; secondly, inject the obtained mixture into the mold and soak in 2mol / L hydrochloric acid solution Sodium alginate and chitosan were fully cross-linked for 24 hours; again, the composite hydrogel was soaked in 0.1mol / L sodium periodate solution, oxidized in a refrigerator at 4°C for 12 hours, and freeze-dried for later use; Finally, soak the oxidized and dried composite hydrogel in 0.8 g / ml indomethacin ammonia water for 24 hours, and dry to obtain the indomethacin-loaded composite hydrogel.

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Abstract

The invention discloses a preparation method of a drug carrier hydrogel with the high biocompatibility. According to the preparation method of the drug carrier hydrogel with the high biocompatibility,sodium alginate tech grade and chitosan are taken as raw materials, the high hydrogel is prepared by using electrostatic interaction between the two polyelectrolytes with opposite charges; meanwhilethe pH sensitivity and the mechanical property of the whole hydrogel are improved through addition of carboxymethyl nanocellulose; furthermore, the degradation property inside the hydrogel is advantageously improved through the oxidized hydrogel; and finally, the composite hydrogel has a certain indometacin slow-release effect. According to the preparation method of the drug carrier hydrogel withthe high biocompatibility, the used raw materials are the sodium alginate tech grade, the chitosan and the carboxymethyl nanocellulose, and the good environmental friendliness and the good biocompatibility are achieved; and the reaction condition is mild, chemical substances such as a cross-linking agent and a photoinitiator are not needed, and a novel thought is provided for indometacin slow-release.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of a highly biocompatible drug carrier hydrogel. Background technique [0002] Hydrogel is a kind of hydrophilic polymer, which can form a cross-linked network structure chemically or physically. Hydrogel is insoluble in water and can absorb water to swell. After swelling, the hydrogel will maintain its original solid shape. Hydrogel is soft, has high water content, and has good biocompatibility and biodegradability. It is a kind of biomaterial with excellent performance. It plays an important role in the field of bioengineering and drug delivery. The hydrogel can be loaded with a certain drug to fix it at a specific site for local treatment, and it can also prolong the release time of the drug and reduce the side effects of the drug. The common raw materials for preparing hydrogels are: guar gum, chitosan, cellulose, sodium alginate, starch, et...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K31/405A61P29/00
CPCA61K9/0024A61K9/06A61K47/36A61K31/405A61P29/00
Inventor 唐艳军毛江淳
Owner ZHEJIANG SCI-TECH UNIV
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