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A bioactive bone repair scaffold and preparation method thereof

A bioactive, bone repair technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problem that cartilage and subchondral bone cannot be repaired together, so as to reduce cartilage degradation damage, reduce costs, and inhibit the secretion of cytokines Effect

Active Publication Date: 2021-12-07
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem: The purpose of the present invention is to provide a bioactive bone repair scaffold and its preparation method. The internal and external structures of the scaffold can be customized, with zero addition of organic solvents, and good multi-component interface bonding, which can meet the mechanical strength requirements of cancellous bone (0.2 ~ 80Mpa), realized the material design of functional bone repair scaffolds, as well as the self-responsive release of functional ions during service, the deposition and mineralization of apatite, and solved the incompatibility of cartilage and subchondral bone in the process of joint damage repair. fix puzzle

Method used

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  • A bioactive bone repair scaffold and preparation method thereof
  • A bioactive bone repair scaffold and preparation method thereof
  • A bioactive bone repair scaffold and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A bioactive bone repair scaffold. The bioactive bone repair scaffold uses a degradable polymer as a matrix, lithium magnesium silicate and magnesium as a reinforcing phase, and includes:

[0043] Lithium magnesium silicate 5%,

[0044] Magnesium 10%,

[0045] Degradable polymer 85%.

[0046] in:

[0047] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 85% and a pore diameter of 800 μm.

[0048] The magnesium and magnesium-lithium silicate are both granular reinforcing phases, wherein the magnesium-lithium silicate is a powder with a particle size of 50-100 μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥ 99.8 wt%, in a regular spherical shape, with a particle size of less than 40 μm .

[0049] The degradable polymer is powdery D-polylactic acid PDLA.

[0050] Its preparation steps are as follows:

[0051] S1. Pre-gel: Weigh 0.5g of magnesium lithium silicate powder, add it to 1L of deionized wa...

Embodiment 2

[0057] A bioactive bone repair scaffold. The bioactive bone repair scaffold uses a degradable polymer as a matrix, lithium magnesium silicate and magnesium as a reinforcing phase, and includes:

[0058] Lithium Magnesium Silicate 10%,

[0059] Magnesium 20%,

[0060] Degradable polymer 70%.

[0061] in:

[0062] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 80% and a pore diameter of 700 μm.

[0063] The magnesium and magnesium-lithium silicate are both granular reinforcing phases, wherein the magnesium-lithium silicate is a powder with a particle size of 50-100 μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥ 99.8 wt%, in a regular spherical shape, with a particle size of less than 40 μm .

[0064] The degradable polymer is powdered polycaprolactone PCL.

[0065] Its preparation steps are as follows:

[0066] S1. Pre-gel: Weigh 1.0g of lithium magnesium silicate powder, add it to 1L of deionized wa...

Embodiment 3

[0072] A bioactive bone repair scaffold. The bioactive bone repair scaffold uses a degradable polymer as a matrix, lithium magnesium silicate and magnesium as a reinforcing phase, and includes:

[0073] Lithium Magnesium Silicate 12%,

[0074] Magnesium 24%

[0075] Degradable polymer 64%.

[0076] in:

[0077] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 75% and a pore diameter of 600 μm.

[0078] The magnesium and magnesium-lithium silicate are both granular reinforcing phases, wherein the magnesium-lithium silicate is a powder with a particle size of 50-100 μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥ 99.8 wt%, in a regular spherical shape, with a particle size of less than 40 μm .

[0079] The degradable polymer is powdered poly-L-lactic acid PLLA.

[0080] Its preparation steps are as follows:

[0081] S1. Pre-gel: Weigh 1.2g of lithium magnesium silicate powder, add it to 1L of deionized ...

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Abstract

The invention discloses a bioactive bone repairing scaffold and a preparation method thereof. The bioactive bone repairing scaffold uses a degradable polymer as a matrix, lithium magnesium silicate and magnesium as a reinforcing phase, and includes: lithium magnesium silicate 5-5% by mass percentage 15%, magnesium 10-30%, degradable polymer 55-85%. The preparation steps are as follows: 1) preparation of lithium magnesium silicate hydrogel; 2) preparation of mixture; 3) preparation of 3D printing raw material particles; 4) 3D printing of bioactive bone repair scaffold. The internal and external structure of the scaffold can be customized, with zero addition of organic solvents, and the multi-component interface is well combined, which can meet the mechanical strength requirements of cancellous bone (0.2-80Mpa). Deposition can synergistically repair bone and cartilage injuries, realize the individualized preparation of bioactive bone repair scaffolds, and broaden its application prospects in the fields of rehabilitation and treatment of bone and cartilage injuries.

Description

technical field [0001] The invention relates to a bioactive bone repair bracket and a preparation method thereof, belonging to the technical field of material preparation. Background technique [0002] Bone grafting scaffolds provide new ideas for joint bone repair and regeneration. About 2.2 million bone scaffolds are used in orthopedic surgery every year in the world, mainly to stimulate new bone formation to replace and regenerate bones caused by joint trauma and disease infection. defect. Orthopedic implant products mainly include spine products, trauma products, artificial bone joint products, etc. At present, joints, trauma and spine are the three mainstream categories of orthopedic medical devices in China. With the advent of aging, bone and joint injury repair will be the fastest growing field in the future. [0003] Articular cartilage injury is one of the most challenging problems in orthopedics and sports medicine given the poor self-healing ability of articular...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/04A61L27/02A61L27/50A61L27/54A61L27/56A61L27/58B33Y10/00B33Y70/10
CPCA61L27/025A61L27/047A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/412A61L2430/06B33Y10/00B33Y70/00C08L67/04
Inventor 白晶周星星董强胜姚庆强张明张惠康程兆俊薛烽
Owner SOUTHEAST UNIV
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