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Biphasic transdermal drug delivery system and preparation method thereof

A drug delivery system and drug-carrying technology, which is applied in pharmaceutical formulations, drug delivery, medical preparations of non-active ingredients, etc., can solve the problems of inapplicable temperature-sensitive drugs, active drugs prone to inactivation, and uncontrollable release rates, etc. problems, achieve good skin affinity and transdermal performance, good skin compatibility, and improve solubility

Active Publication Date: 2019-10-22
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the field of drug delivery, the traditional preparation methods of drug-loaded microspheres include double emulsion method, spray drying method and coacervation method, etc., but these methods suffer from sudden drug release, uncontrollable release rate, and easy inactivation of active drugs during the entrapment process. And defects such as not being suitable for temperature-sensitive drugs due to heating in the preparation process

Method used

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  • Biphasic transdermal drug delivery system and preparation method thereof
  • Biphasic transdermal drug delivery system and preparation method thereof
  • Biphasic transdermal drug delivery system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Configure silk fibroin spinning solution (solvent is water) containing 20% ​​silk fibroin (mass volume ratio) and 2% PEO (mass volume ratio), and add drug-loaded alcohol according to the volume ratio of 40% Plastid, medicine is doxorubicin hydrochloride, concentration is 1mg / mL (mass volume ratio);

[0031] (2) Transfer the spinning solution in step (1) to the syringe, and set the electrospinning parameters: the voltage is 12kV, the advancing speed is 1mL / h, the receiving distance is 15cm, the temperature is 25°C, and the humidity is 10%. The receiver receives and prepares the drug-loaded ethosome-silk fibroin nanofiber membrane;

[0032] (3) placing the nanofibrous membrane prepared in step (2) in a fumigator filled with 75% ethanol for crosslinking for 24 hours;

[0033] (4) Configure 10% polyvinylpyrrolidone K30 (mass volume ratio) electrospray solution (solvent is 1-10:10-100 ethanol aqueous solution by mass ratio), and add drug-loaded alcohol in a ratio of 40%...

Embodiment 2

[0041] (1) Configure a collagen spinning solution (solvent is water) containing 20% ​​collagen (mass volume ratio) and 2% PEO (mass volume ratio), and add drug-loaded ethosomes according to the volume ratio of 40% , the medicine is ketoprofen, and the concentration is 1mg / mL (mass volume ratio);

[0042] (2) Transfer the spinning solution in step (1) to the syringe, and set the electrospinning parameters: the voltage is 15kV, the advancing speed is 0.5mL / h, the receiving distance is 10cm, the temperature is 30°C, and the humidity is 5%. Received by the receiver to prepare the drug-loaded ethosome-silk fibroin nanofiber membrane;

[0043] (3) placing the nanofibrous membrane prepared in step (2) in a fumigator filled with 75% ethanol for crosslinking for 24 hours;

[0044] (4) Configure 10% polyvinylpyrrolidone k30 (mass volume ratio) electrospray solution (solvent is 1-10:10-100 ethanol aqueous solution by mass ratio), and add drug-loaded alcohol in a ratio of 40% by volume ...

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Abstract

The invention relates to a biphasic transdermal drug delivery system and a preparation method thereof. The system is obtained by receiving electrospray drug-loading ethosome composite microspheres byusing a drug-loading ethosome / natural material nanofiber membrane as a receiver. The system of the invention has good skin compatibility, is air-permeable and water-permeable, is softer after being wet and fits the skin more tightly, and is an ideal material for transdermal drug delivery patches.

Description

technical field [0001] The invention belongs to the field of drug carriers, in particular to a biphasic transdermal drug delivery system and a preparation method thereof. Background technique [0002] The transdermal drug delivery system is a drug controlled release system that absorbs drugs through the skin and enters the blood circulation to treat or prevent diseases. Improve patient tolerance and other advantages. An ideal transdermal drug delivery patch requires good adhesion to the skin, good flexibility, air permeability, high transdermal efficiency, and easy use. At the same time, it should take into account the characteristics of wide sources of raw materials, low cost, and easy mass production. [0003] Ethosomes are special liposomes containing low-molecular-weight alcohols. The hydrophilic head and hydrophobic tail in its structure indicate that it can effectively encapsulate not only hydrophilic drugs, but also lipophilic drugs. Many evidences show that ethoso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/127A61K31/704A61K45/00A61K47/32A61K47/36A61K47/42B05D1/04D01D5/00
CPCA61K9/7007A61K9/1271A61K9/0014A61K45/00A61K47/32A61K47/42A61K47/36A61K31/704D01D5/003D01D5/0092B05D1/04
Inventor 王红声张东东宋新然洪火炎马琳琳
Owner DONGHUA UNIV
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