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Bionic stent simulating natural tendon tissue fiber hierarchical structure and preparation method of bionic stent

A fiber structure and tendon technology, applied in the field of bionic materials, can solve problems such as the inability to biomimetic natural tendon tissue fiber hierarchy, and achieve the effects of avoiding tissue adhesion, reducing inflammation, and adjusting mechanical properties

Pending Publication Date: 2019-10-18
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a bionic scaffold for simulating the hierarchical structure of natural tendon tissue fibers and its preparation method, so as to overcome the defect that the prior art cannot simulate the hierarchical structure of natural tendon tissue fibers

Method used

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  • Bionic stent simulating natural tendon tissue fiber hierarchical structure and preparation method of bionic stent
  • Bionic stent simulating natural tendon tissue fiber hierarchical structure and preparation method of bionic stent
  • Bionic stent simulating natural tendon tissue fiber hierarchical structure and preparation method of bionic stent

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Embodiment 1

[0058] (1) Extraction of silk fibroin: cut the silkworm cocoons, remove the silkworm chrysalis, peel off the silkworm cocoons into several layers, put them in a 0.5% sodium bicarbonate aqueous solution and boil for 30 minutes, repeat twice to remove the surface sericin, rinse thoroughly with deionized water, After drying, pure silk fibroin fibers can be obtained. Place silk fibroin fibers in CaCl 2 / H 2 O / absolute ethanol (molar ratio: 1:8:2) ternary solvent, heated to 70°C to dissolve for 40 minutes, then put into a dialysis bag with a molecular weight cut-off of 14000Da and dialyzed at room temperature for 3 days, and filtered the solution to obtain pure The silk fibroin aqueous solution is freeze-dried to obtain spongy silk fibroin.

[0059] (2) Preparation of spinning solution: Weigh 0.6g of P(LLA-CL) (75:25) with a molecular weight of about 200,000 (purchased from Jinan Daigang Biotechnology Co., Ltd.) and 0.2g of silk fibroin in 10mL Hexafluoroisopropanol (purchased f...

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Abstract

The invention relates to a bionic stent simulating a natural tendon tissue fiber hierarchical structure and a preparation method of the bionic stent. The material is a multi-hierarchical structure simulating tendon tissue fibers. A double-nozzle spinning head is adopted, positive and negative electric fields are respectively added, nano fibers are received through a rotating funnel and twisted oncore layer yarns, and stable and continuous primary core-spun yarns are prepared. A plurality of primary core-spun yarns are stranded to serve as core layer yarns, nano fibers are electrostatically spun on the outer layers, the obtained secondary core-spun yarns are stranded to serve as a core layer, nano fibers are electrostatically spun on the outer layer, and tertiary core-spun yarns with a fiber multi-hierarchical structure simulating tendon tissues are prepared and used for a tendon repair stent. The bionic stent is beneficial to tendon repair and normal function recovery, is quite suitable to be used as a tendon injury repair and medical instrument material, and has good application prospect; the preparation method is simple and convenient; and the production efficiency is high.

Description

technical field [0001] The invention belongs to the field of bionic materials, and in particular relates to a bionic support for simulating the hierarchical structure of natural tendon tissue fibers and a preparation method thereof. Background technique [0002] With the progress of human civilization and people's pursuit of health, people's outdoor sports have increased significantly. Due to the continuous occurrence of accidents and the increasingly obvious trend of aging society, sports injuries are also increasing, of which more than 50% of tendons and ligaments are injured. Statistics show that there are at least 30 million patients with tendon injuries every year. Due to the limited ability of tendons and ligaments to regenerate, healing is often accompanied by the formation of fibrotic scar tissue. At present, the repair methods of tendon injury mainly include autologous tendon transplantation, xenogeneic tendon transplantation, and artificial tendon replacement. I...

Claims

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Application Information

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IPC IPC(8): D02G3/44D02G3/36D02G3/04A61F2/82
CPCD02G3/448D02G3/36D02G3/045A61F2/82D10B2331/04D10B2211/20
Inventor 莫秀梅谢宪瑞吴晶磊陈玉杰
Owner DONGHUA UNIV
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