Compositions comprising amide derivatives and their use in cosmetics

The technology of an amide derivative and a composition is applied to the composition and its application field in cosmetics, which can solve the problems of low toxicity and irritation, toxicity and irritation, etc., to increase the skin, reduce the darkening of the skin, and inhibit the melanin of the skin. calm effect

Active Publication Date: 2022-05-24
广州双慧化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various skin care compositions and regimens have been widely developed in recent years, however, some active ingredients exhibit side effects such as toxicity and irritation while exhibiting skin lightening, therefore, there is an urgent need to develop Composition with excellent effect on the skin

Method used

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  • Compositions comprising amide derivatives and their use in cosmetics
  • Compositions comprising amide derivatives and their use in cosmetics
  • Compositions comprising amide derivatives and their use in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Compositions containing amide derivatives Formulation 1:

[0053] The present embodiment provides a composition comprising an amide derivative, comprising:

[0054] a. the amide derivative (A) represented by the formula (1a);

[0055]

[0056] b. Resorcinol derivative (B) represented by formula (2a);

[0057]

[0058] c. At least one cosmetically acceptable component (C).

[0059] In the content and preferred embodiments of the present invention, the amide derivative (A) represented by the formula (1a) is specifically: (1S,3S,5S)-2-benzyloxycarbonyl-2-azabicyclo[ 3.1.0]-Hexane-3-carboxamide.

[0060] The combined use of the composition comprising the amide derivative (A) represented by the formula (1) and the resorcinol derivative (B) represented by the formula (2) according to the present invention has a positive effect on the skin, and the amide contained therein has a positive effect on the skin. Derivatives have a positive enhancement effect on th...

Embodiment 2～6

[0073] Examples 2-6: Compositions Containing Amide Derivatives Formulations 2-6:

[0074] Examples 2 to 6 respectively provide the following composition formulations containing amide derivatives with formulations 2 to 6, the specific components of which are shown in Table 1.

[0075] Table 1, composition formula 2~6

[0076]

[0077]

experiment example 1

[0088] Experimental Example 1: Skin Permeability Diffusion Experiment:

[0089] Skin penetration studies were performed on the compositions of Examples 1-6, Comparative Examples 7-17 above, using a Franz diffusion cell maintained at 37°C during the experiment. The receptor medium is phosphate buffer at pH 7.4, the receptor volume is 12 mL and the permeation area is 1.77 cm 2 . Hairless full-thickness pig skin (approximately 1.5 mm) was used and all assays were performed in triplicate. 400 [mu]L of each formulation was placed at the donor site of the skin diffusion cell and the experiment was started with continuous mixing of the acceptor medium. Acceptor phase samples were collected at 1, 12, 24 and 48 h using HPLC [Waters C18XBridge, 3.5 μm, 4.6 mm × 150 mm, mobile phase was 20 mM potassium phosphate buffer (pH 4.4):acetonitrile (80:20), flow rate 1 mL / min, injection volume 10 μL, detection at 216 nm, column temperature 40 °C, running time 10 min] to measure the permeabili...

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Abstract

The present invention relates to the field of cosmetics, in particular to a composition comprising amide derivatives and its application in cosmetics, said composition comprising: a. at least one amide derivative (A) represented by formula (1) b. at least one resorcinol derivative (B) represented by formula (2); and c. at least one cosmetically acceptable component (C). The amide derivative contained in the composition described in the present application has a positive enhancement effect on the transdermal delivery of the composition, which is beneficial for the active substance of the composition to penetrate through each layer of skin to reach the site of action, and to prevent skin melanosis, skin aging, etc. The prevention and / or inhibition of visible discontinuous appearance changes of the skin caused by or other diseases, the treatment, regulation or prevention of skin oxidative stress or degenerative process, the inhibition of melanin production and precipitation, the reduction of skin color deepening, the increase of skin, the skin Stay translucent and fair.

Description

technical field [0001] The present invention relates to the field of cosmetics, in particular to a composition comprising an amide derivative and its application in cosmetics, Background technique [0002] The skin is covered on the surface of the human body and is in direct contact with the external environment. It has functions such as protection, sensation, secretion, excretion, and respiration. The skin is closely combined with the epidermis and the dermis. The epidermis is composed of stratified squamous epithelium, which is composed of stratum corneum, transparent layer, granular layer and germinal layer from shallow to deep. Water permeable, with functions such as preventing the outflow of tissue fluid, anti-friction and anti-infection. The cells of the germinal layer continue to proliferate and gradually migrate outward to replenish the shedding stratum corneum. The germinal layer contains a type of melanocytes that can produce melanin, and the color of the skin is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/49A61Q19/02A61Q19/08A61P17/00A61P17/18A61P39/06
CPCA61K8/492A61K8/4966A61Q19/02A61Q19/08A61P17/00A61P17/18A61P39/06A61K2800/592
Inventor 刘海舟
Owner 广州双慧化妆品有限公司
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