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Compound platycodon grandiflorum cough-stopping solution preparation for inhalation and preparing method thereof

A technology of Platycodon grandiflorum and solution, which is applied in the field of pharmacy, can solve the problems that the instructions do not have standardized methods of use, does not include inhalants, and hidden safety hazards in use, and achieves the effects of quick onset of action, high drug concentration, and low dosage

Inactive Publication Date: 2019-10-11
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1365724A discloses a kind of nano-compound bellflower antitussive medicine and preparation method thereof, but limited to pills, powders, tablets, suppositories, etc., excluding inhalants
In clinical practice, nebulized inhalation with injection is often used, but there is no standardized method of use in the instructions, and there are potential safety hazards in use

Method used

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  • Compound platycodon grandiflorum cough-stopping solution preparation for inhalation and preparing method thereof
  • Compound platycodon grandiflorum cough-stopping solution preparation for inhalation and preparing method thereof
  • Compound platycodon grandiflorum cough-stopping solution preparation for inhalation and preparing method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Compound Platycodon grandiflora cough solution for inhalation 1000ml:

[0037]

[0038]Weigh Platycodon grandiflorum, add water and decoct 3 times, add water 12 times, decoct for 4 hours, filter, combine the filtrate, concentrate, cool, add ethanol until the ethanol content is 70%, let stand for more than 8 hours after stirring, filter, recover the filtrate, add water 4 times, passed through a macroporous resin column, washed with water, and eluted with 40% ethanol, collected the eluate, recovered ethanol, concentrated to dryness, and obtained the active ingredients of Platycodon grandiflorum, honey coltsfoot flower, and licorice, and decocted them for 3 times , add 12 times the amount of water, decoct for 4 hours, filter, combine the filtrate, add ethanol until the ethanol content is 80%, stir well, let stand for more than 12 hours, filter, recover ethanol, add water, stand for more than 24 hours, filter, ultrafilter , concentrated to dryness, to obtain the active i...

Embodiment 2

[0040] Compound Platycodon grandiflora cough solution for inhalation 1000ml:

[0041]

[0042] Weigh Platycodon grandiflorum, add water to decoct 3 times, add water 8 times, decoct for 2 hours, filter, combine the filtrate, concentrate, cool, add ethanol until the ethanol content is 85%, stir well and let stand for more than 12 hours, filter, recover the filtrate, add water 4 times, passed through a macroporous resin column, washed with water, and eluted with 40% ethanol, collected the eluate, recovered ethanol, concentrated to dryness, and obtained the active ingredients of Platycodon grandiflorum, honey coltsfoot flower, and licorice, and decocted them for 3 times , add 10 times the amount of water, decoct for 3 hours, filter, combine the filtrates, add ethanol until the ethanol content is 80%, stir well, let stand for more than 12 hours, filter, recover ethanol, add water, stand for more than 24 hours, filter, ultrafilter , concentrated to dryness, to obtain the active i...

Embodiment 3

[0044] Compound Platycodon grandiflora cough solution for inhalation 1000ml:

[0045]

[0046] Weigh Platycodon grandiflorum, add water and decoct 3 times, add water 10 times, decoct for 2 hours, filter, combine the filtrate, concentrate, cool, add ethanol until the ethanol content is 80%, stir well and let stand for more than 12 hours, filter, recover the filtrate, add water 4 times, passed through a macroporous resin column, washed with water, and eluted with 40% ethanol, collected the eluate, recovered ethanol, concentrated to dryness, and obtained the active ingredients of Platycodon grandiflorum, honey coltsfoot flower, and licorice, and decocted twice , add 10 times the amount of water, decoct for 2 hours, filter, combine the filtrates, add ethanol until the ethanol content is 80%, stir well, let stand for more than 12 hours, filter, recover ethanol, add water, stand for more than 24 hours, filter, ultrafilter , concentrated to dryness, to obtain the active ingredient...

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Abstract

The invention relates to a compound platycodon grandiflorum cough-stopping solution preparation for inhalation and a preparing method thereof, and belongs to the field of the pharmaceutics technology.The solution preparation is prepared from traditional Chinese medicine raw materials (platycodon grandiflorum, honey-stir-baked radix polygalae, honey-stir-baked flos farfarae and licorice root) andauxiliary materials (an isotonic agent and a solvent), wherein the consumption ratio of platycodon grandiflorum to honey-stir-baked radix polygalae to honey-stir-baked flos farfarae to licorice root used in the compound platycodon grandiflorum cough-stopping solution preparation for inhalation is (80-200):(20-60):(10-30):(5-20). The compound platycodon grandiflorum cough-stopping solution preparation for inhalation can rapidly form aerosol through an atomizer, the formed aerosol can directly and rapidly act on an affected part, and the medicine acting on the affected part can be rapidly absorbed to have an effect; the use dosage is small, the effect is rapidly realized, the treatment effect is good, and no other toxic or side effects exist.

Description

technical field [0001] The invention relates to a compound platycodon grandiflorum cough solution preparation for inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Compound platycodon grandiflora cough prescription consists of platycodon grandiflorum, honey polygala, honey coltsfoot flower and licorice and other components. Platycodon grandiflorum: clears the lungs, clears the throat, eliminates phlegm, and expels pus; honey polygala: soothes the nerves and improves intelligence, communicates with the heart and kidney, eliminates phlegm, reduces swelling; honey coltsfoot: moistens the lungs and lowers qi, relieves cough and reduces phlegm; licorice: nourishes the spleen and replenishes qi , heat-clearing and toxic substances removing, expelling phlegm and relieving cough, relieving spasm and relieving pain, harmonizing various medicines. [0003] At present, the only dosage form developed by using the prescription...

Claims

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Application Information

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IPC IPC(8): A61K36/69A61K9/72A61P11/14A61P11/10
CPCA61K9/0078A61K9/08A61K36/28A61K36/346A61K36/484A61K36/69A61K47/02A61K47/26A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 张保献胡杰王志华
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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