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Preparation method of hollow mesoporous silica antibacterial agent grafted with guanidine salt polymer

A guanidine salt polymer and silica technology, which is applied in the directions of botanical equipment and methods, chemical instruments and methods, animal repellents, etc., can solve the problem that the combination of hollow mesoporous silica and guanidine salt polymers cannot be realized. and other problems, to achieve the effect of low cost, simple operation process, efficient and broad-spectrum sterilization effect

Inactive Publication Date: 2019-10-11
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem mainly solved by the present invention is to provide a preparation method of grafted guanidinium salt polymer hollow mesoporous silica antibacterial agent to solve the problem that the combination of hollow mesoporous silica and guanidinium salt polymer cannot be realized in the prior art The problem

Method used

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  • Preparation method of hollow mesoporous silica antibacterial agent grafted with guanidine salt polymer
  • Preparation method of hollow mesoporous silica antibacterial agent grafted with guanidine salt polymer
  • Preparation method of hollow mesoporous silica antibacterial agent grafted with guanidine salt polymer

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Effect test

Embodiment 1

[0031] Weigh 100g of deionized water, 0.5g of emulsifier cetyltrimethylammonium bromide and mix them, fully stir for 20-30min to form a water phase, weigh 13g of tetraethyl orthosilicate, 0.65g of KH560, 1.5g of hydrophobic solvent A Base silicone oil, 0.5g co-stabilizer hexadecane mixed, ultrasonic 15-30min to form an oil phase, slowly add the oil phase to the water phase and continue stirring for 20-30min to obtain a pre-emulsion; under the condition of ice water bath, use a homogeneous emulsifier Emulsify the pre-emulsion at 16,000rpm for 5min to prepare a mini-emulsion; add 0.38g of cross-linking agent triethylamine to the mini-emulsion and stir at room temperature for 24h to obtain epoxy-modified hollow mesoporous silica, which is centrifuged and washed with absolute ethanol at a low speed After 3-5 times, dry it for later use;

[0032] Ultrasonically disperse 0.2g of epoxy-modified hollow mesoporous silica in 250ml of deionized water, add 3g of 25wt% PHMG aqueous solutio...

Embodiment 2

[0036] Weigh 100g of deionized water, 0.5g of emulsifier cetyltrimethylammonium bromide and mix them, fully stir for 20-30min to form a water phase, weigh 13g of tetraethyl orthosilicate, 1.3g of KH560, 1.5g of hydrophobic solvent A Base silicone oil, 0.5g co-stabilizer hexadecane mixed, ultrasonic 15-30min to form an oil phase, slowly add the oil phase to the water phase and continue stirring for 20-30min to obtain a pre-emulsion; under the condition of ice water bath, use a homogeneous emulsifier Emulsify the pre-emulsion at 16000rpm for 5min to prepare a mini-emulsion; add 0.38g of cross-linking agent triethylamine to the mini-emulsion and stir at room temperature for 24h to obtain epoxy-modified hollow mesoporous silica, which is centrifuged and washed with absolute ethanol at a low speed After 3-5 times, dry it for later use;

[0037] Ultrasonically disperse 0.2g of epoxy-modified hollow mesoporous silica in 250ml of deionized water, add 3g of 25wt% PHMG aqueous solution,...

Embodiment 3

[0041] Weigh 100g of deionized water, 0.5g of emulsifier cetyltrimethylammonium bromide and mix them, stir thoroughly for 20-30min to form a water phase, weigh 13g of tetraethyl orthosilicate, 1.95g of KH560, 1.5g of hydrophobic solvent A Base silicone oil, 0.5g co-stabilizer hexadecane mixed, ultrasonic 15-30min to form an oil phase, slowly add the oil phase to the water phase and continue stirring for 20-30min to obtain a pre-emulsion; under the condition of ice water bath, use a homogeneous emulsifier Emulsify the pre-emulsion at 16,000rpm for 5min to prepare a mini-emulsion; add 0.38g of cross-linking agent triethylamine to the mini-emulsion and stir at room temperature for 24h to obtain epoxy-modified hollow mesoporous silica, which is centrifuged and washed with absolute ethanol at a low speed After 3-5 times, dry it for later use;

[0042] Ultrasonically disperse 0.2g of epoxy-modified hollow mesoporous silica in 250ml of deionized water, add 3g of 25wt% PHMG aqueous so...

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Abstract

The invention discloses a hollow mesoporous silica antibacterial agent grafted with a guanidine salt polymer and a preparation method thereof. The method includes the following steps that (1), epoxy modified hollow mesoporous silica microspheres are synthesized by a miniemulsion method, wherein an inorganic silicon source monomer, gamma-glycidyl ether oxypropyl trimethoxysilane, a hydrophobic solvent and a co-stabilizer serve as oil phases, an emulsifier and deionized water serve as water phases, and the oil phases and the water phases are mixed, homogenized and emulsified to obtain miniemulsion; a cross-linking agent is added for magnetic stirring at room temperature for 24 hours, and then epoxy modified hollow mesoporous silica microspheres are obtained; (2), guanidine salt polymer-polyhexamethylene guanide hydrochloride (PHMG) is prepared; (3), the epoxy modified hollow mesoporous silica is dispersed in water, a PHMG aqueous solution is added, and after magnetic stirring at room temperature for a certain time, the hollow mesoporous silica microspheres grafted with the guanidine salt polymer is obtained. The PHMG is grafted onto the surfaces of the hollow mesoporous silica microspheres to prepare the novel antibacterial agent, the antibacterial agent has excellent antibacterial performance, and involved raw materials are cheap, easy to obtain, and environmentally friendly.

Description

technical field [0001] The invention relates to the technical field of functional composite materials, in particular to a method for preparing a grafted guanidinium polymer hollow mesoporous silicon dioxide antibacterial composite material. Background technique [0002] Hollow mesoporous silica spheres have the dual advantages of hollow and mesoporous, the regular pore structure and the spherical hollow part greatly increase its specific surface area, and the raw materials are abundant, cheap, easy to prepare, high in bioavailability, and easy to use. Many advantages such as chemical modification make it a good carrier material used in catalysis, biomedicine and other aspects, especially in drug sustained release, showing good application prospects. [0003] As a guanidinium salt polymer, polyhexamethyleneguanidine hydrochloride (PHMG) is easily soluble in water. Its aqueous solution is colorless, odorless, non-flammable and non-explosive. It has a strong killing effect on b...

Claims

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Application Information

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IPC IPC(8): A01N25/08A01N47/44A01P1/00C08G83/00C08G73/00C02F1/50C02F1/28
CPCA01N25/08A01N47/44C02F1/281C02F1/50C08G73/00C08G83/001
Inventor 杨建军张孜文吴庆云张建安吴明元刘久逸
Owner ANHUI UNIVERSITY
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