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Extraction method of medicinal components of Chinese magnoliavine fruits, formula granules of medicinal components of Chinese magnoliavine fruits and preparation method of formula granules

The technology of medicinal ingredients and extraction method is applied in the field of extraction of medicinal ingredients of Schisandra chinensis and the preparation of formula granules and formula granules, and can solve the problems of unstable structure of lignans and low content of lignans, etc. Achieve the effect of high content of lignans, good drug stability and low content of excipients

Active Publication Date: 2019-09-27
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems that the structure of lignans in the extraction process of the existing medicinal ingredients of Schisandra chinensis is unstable, easy to be oxidized and destroyed, resulting in low content of lignans in the extract or even complete degradation, the present invention provides a Extraction of Schisandra Medicinal Components and Its Formula Granules and Preparation Method of Formula Granules

Method used

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  • Extraction method of medicinal components of Chinese magnoliavine fruits, formula granules of medicinal components of Chinese magnoliavine fruits and preparation method of formula granules
  • Extraction method of medicinal components of Chinese magnoliavine fruits, formula granules of medicinal components of Chinese magnoliavine fruits and preparation method of formula granules
  • Extraction method of medicinal components of Chinese magnoliavine fruits, formula granules of medicinal components of Chinese magnoliavine fruits and preparation method of formula granules

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Embodiment 1

[0038] A method for extracting medicinal components of Schisandra chinensis, comprising the following steps:

[0039] a. Weigh the schisandra medicinal material, remove visible foreign matter and impurities, and use a powerful crusher to break the peel to scatter the internal seeds;

[0040] b. Put the pulverized schisandra into an extraction tank, add pure water 22 times the mass of schisandra and heat to 100° C., add β-cyclodextrin of 5% by mass of schisandra and sodium bicarbonate of 0.05% by mass of schisandra, and stir evenly. Continue to add pure water 12 times the mass of Schisandra chinensis, heat to 100°C, extract for 25 minutes, filter, separate the filter residue to obtain filtrate 1; add pure water 10 times the quality of the filter residue to the separated filter residue, add β- Cyclodextrin and Schisandra chinensis 1% sodium bicarbonate, heating to 100°C, extracting for 15 minutes, filtering, separating the filter residue to obtain filtrate 2; combining filtrate ...

Embodiment 2

[0048] A method for extracting medicinal components of Schisandra chinensis, comprising the following steps:

[0049] a. Weigh the schisandra medicinal material, remove visible foreign matter and impurities, and use a powerful crusher to break the peel to scatter the internal seeds;

[0050] b. Put the crushed schisandra into the extraction tank, add pure water 14 times the mass of schisandra and heat to 95°C, add 4% schisandra β-cyclodextrin and 0.1% schisandra sodium bicarbonate, stir evenly, Continue to add pure water 8 times the mass of Schisandra chinensis, heat to 98°C, extract for 30 minutes, filter, separate the filter residue to obtain filtrate 1; add pure water 6 times the quality of the filter residue to the separated filter residue, add 2% of the mass of Schisandra β- Cyclodextrin and Schisandra chinensis 2% sodium bicarbonate, heating to 98°C, extracting for 20 minutes, filtering, separating the filter residue to obtain filtrate 2; combining filtrate 1 and filtrat...

Embodiment 3

[0058] A method for extracting medicinal components of Schisandra chinensis, comprising the following steps:

[0059] a. Weigh the schisandra medicinal material, remove visible foreign matter and impurities, and use a powerful crusher to break the peel to scatter the internal seeds;

[0060] b. Put the crushed schisandra into an extraction tank, add pure water 18 times the mass of schisandra and heat to 98°C, add β-cyclodextrin of 5% by mass of schisandra and sodium bicarbonate of 0.08% by mass of schisandra, stir evenly, Continue to add pure water 10 times the mass of Schisandra chinensis, heat to 100°C, extract for 25 minutes, filter, separate the filter residue to obtain filtrate 1; add pure water 8 times the quality of the filter residue to the separated filter residue, add β- Cyclodextrin and Schisandra chinensis 1.5% sodium bicarbonate, heated to 100°C, extracted for 15 minutes, filtered, and separated from the filter residue to obtain filtrate 2; combine filtrate 1 and ...

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Abstract

The invention relates to the technical field of traditional Chinese medicine extraction and particularly discloses an extraction method of medicinal components of Chinese magnoliavine fruits, formula granules of the medicinal components of the Chinese magnoliavine fruits and a preparation method of the formula granules. The extraction method of the medicinal components of the Chinese magnoliavine fruits comprises the steps as follows: a, crushing the Chinese magnoliavine fruits; b, adding purified water to the crushed Chinese magnoliavine fruits, adding beta-cyclodextrin and sodium bicarbonate, uniformly mixing the mixture, performing heating extraction and filtration, and separating filter residues to obtain filtrate; c, adding ethanol with the mass being 5%-10% of the filtrate to the filtrate, and performing concentration and drying on the filtrate to obtain dry extract powder. The content of lignan components in the extracted dry extract powder of the medicinal components of the Chinese magnoliavine fruits is high, the medicinal value and curative effect of the medicinal components are increased, the yield of the medicinal components is increased, and the finished product is bright in color and has specific aroma of the Chinese magnoliavine fruits.

Description

technical field [0001] The invention relates to the technical field of extraction of traditional Chinese medicines, in particular to the extraction of medicinal components of schisandra chinensis, its formula granules and a preparation method of the formula granules. Background technique [0002] Schisandra contains active ingredients, such as: lignans (gomisin A, B, C, D, E, F, G, H, schisandrin A, schisandrin B, schisandrin A, schisandra ester A, etc.) , phenolic acid components (protocatechualdehyde, quinic acid) and volatile oil components (α-thujene, α, β-pinene, α-phellandrene, β-terpinene, etc.). Among them, schisandrin A in lignans is an important material basis for Schisandra chinensis to protect the liver, protect the liver, and scavenge free radicals in the body, but schisandrin A has poor water solubility, unstable component structure, and is easily oxidized and destroyed. , the level of its content directly affects the curative effect and quality of Schisandra ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61K47/69A61K9/16A61K47/36A61K47/26A61K131/00
CPCA61K9/1623A61K9/1652A61K9/1682A61K36/57A61K36/79A61K2236/15A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K47/6951
Inventor 孙福仁高晗郝磊李雪利耿彦梅田方李军山
Owner SHINEWAY PHARMA GRP LTD
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