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Preparation of insoluble drug sustained-release film

A technology for insoluble drugs and insoluble drugs, applied in drug delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effect of simple process, low cost and good application prospects

Active Publication Date: 2019-09-27
苏州泉硕纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, although GelMA has many chemical groups attached after modification, it still has good spinnability

Method used

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  • Preparation of insoluble drug sustained-release film
  • Preparation of insoluble drug sustained-release film
  • Preparation of insoluble drug sustained-release film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 1 g of GelMA (substitution degree is 80%), dissolve it in 10 mL of trifluoroethanol, rotate and shake at a speed of 300 rpm on a shaker at 37 °C for 8 hours, take it out, and obtain a clear and transparent solution ; Add 0.1 g of curcumin, and continue to rotate and shake at a speed of 100 rpm on a shaker at 37 ° C for 2 hours to obtain a drug-loaded mixed spinning solution.

[0027] Pour the prepared spinning solution into the liquid feeder (5 mL syringe), use a flattened 25 G injection needle as the injection tube, connect the negative electrode of the high-voltage power supply, connect the aluminum foil fiber receiving plate to the positive electrode, and control the injection volume of the solution by the syringe pump . Turn on the power, adjust the speed of the syringe pump to 1.5 mL / h, adjust the receiving distance to 15 cm, then start the high-voltage power supply, and set the voltage to 15 kV. The GelMA / curcumin nanofiber membrane can be collected. Subse...

Embodiment 2

[0029] Weigh 1 g of GelMA, dissolve it in 10 mL of trifluoroethanol solution, shake it on a shaker at 37 °C at a speed of 300 rpm for 4 hours, take it out, and obtain a clear and transparent solution; then add 0.1 g of rhubarb The element was rotated and shaken at 37°C at a speed of 100 rpm for 2 hours on a shaker to obtain a mixed solution.

[0030] Pour the prepared spinning solution into the liquid feeder (5 mL syringe), use a flattened 25 G injection needle as the injection tube, connect the negative electrode of the high-voltage power supply, connect the aluminum foil fiber receiving plate to the positive electrode, and control the injection volume of the solution by the syringe pump . Turn on the power supply, adjust the speed of the syringe pump to 1 mL / h, adjust the receiving distance to 10 cm, then start the high-voltage power supply, and set the voltage to 13 kV. The GelMA / emodin nanofiber membrane can be collected. Subsequently, the collected membranes were placed...

Embodiment 3

[0032] Weigh 1.5 g of GelMA, dissolve it in 10 mL of trifluoroethanol solution, rotate and shake at a speed of 350 rpm on a shaker at 30 °C for 4 hours, take it out, and obtain a clear and transparent solution; then add 0.25 g of emodin , on a shaker at 30°C at a speed of 100 rpm for 2 hours to obtain a mixed solution.

[0033] Pour the prepared spinning solution into the liquid feeder (5 mL syringe), use a flattened 25G injection needle as the injection tube, connect the negative electrode of the high-voltage power supply, connect the aluminum foil fiber receiving plate to the positive electrode, and control the injection volume of the solution by the syringe pump. Turn on the power supply, adjust the speed of the syringe pump to 6 ml / h, adjust the receiving distance to 20 cm, then start the high voltage power supply, and set the voltage to 18kV. The GelMA / astaxanthin nanofiber membrane can be collected. Subsequently, the collected membranes were placed in a crosslinker solu...

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Abstract

The invention relates to a preparation method of an insoluble drug sustained-release film. The preparation method comprises the following steps of dissolving GelMA in trifluoroethanol to obtain a clear transparent solution, adding an insoluble drug, and uniformly mixing to obtain a spinning solution; then pouring the obtained spinning solution in a liquid feeding device, and performing electrostatic spinning to obtain a GelMA nanofiber loaded with the drug; soaking the whole nanofiber film loaded with the drug in a polymer solution containing an optical crosslinking agent; and finally, taking out the nanofiber film, triggering a crosslinking reaction under UV-irradiation, and performing crosslinking curing on the nanofiber, thereby obtaining the drug sustained-release film. The process is simple and low in cost; and the preparation method can be widely applied to sustained release of various insoluble drugs, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of preparation of medicinal materials, and mainly relates to a preparation method of an insoluble drug slow-release film. Background technique [0002] Poorly soluble drugs generally refer to small molecule drugs with a solubility of less than 10-30 μg / ml. Due to strong intermolecular forces, the crystals of these drugs are difficult to disperse and dissolve in water, thereby hindering their further absorption in the body. Since more than 40% of drugs in the pharmaceutical industry are such poorly soluble small molecules, solubilization has always been a major challenge in the development of pharmaceutical formulations. So far, a variety of techniques have been developed to increase the solubility of poorly soluble drugs, and commonly used methods include changing crystal form, salt formation, surfactant encapsulation, and solid dispersion. Among the many methods mentioned above, although the first three methods can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/42A61K31/12A61K31/122
CPCA61K9/7007A61K47/42A61K31/12A61K31/122A61K2300/00Y02A50/30
Inventor 不公告发明人
Owner 苏州泉硕纳米科技有限公司
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