Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of 5-aminolevulinic acid intercalated LEuH complex

A technology of aminolevulinic acid and complexes, applied in chemical instruments and methods, luminescent materials, etc., can solve problems such as poor molecular stability and complex detection and analysis methods of 5-aminolevulinic acid, achieve excellent performance and improve detection sensitivity Sexuality and strong stability

Inactive Publication Date: 2019-09-20
BEIJING INSTITUTE OF PETROCHEMICAL TECHNOLOGY
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular stability of the 5-ALA drug in the current drug carrier is poor, and the detection and analysis methods of 5-aminolevulinic acid are relatively complicated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of 5-aminolevulinic acid intercalated LEuH complex
  • Preparation method of 5-aminolevulinic acid intercalated LEuH complex
  • Preparation method of 5-aminolevulinic acid intercalated LEuH complex

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] A preparation method for a 5-aminolevulinic acid intercalation LEuH complex may include:

[0019] According to the molar ratio of NaOH:5-aminolevulinic acid=0.7~1.5:1, NaOH is added to the aqueous solution of 5-aminolevulinic acid for deprotonation, so as to prepare the sodium salt solution containing 5-aminolevulinic acid . Disperse LEuH in deionized water, add a sodium salt solution containing 5-aminolevulinic acid, then place it at 70-100°C for 12-24 hours, then wash and dry it to obtain 5-aminolevulinic acid Intercalation of LEuH complexes.

[0020] Specifically, the preparation method of the 5-aminolevulinic acid intercalation LEuH complex may include the following embodiments:

[0021] (1) The molar ratio of 5-aminolevulinic acid to LEuH is 3:1.

[0022] (2) The preparation method of the LEuH includes: using 1-2 mmol of hexamethylenetetramine, 1-2 mmol of Eu(NO 3 ) 3 ·6H 2 O, 13~26mmol NaNO 3 The ratio of Eu(NO 3 ) 3 ·6H 2 O, NaNO 3 . Hexamethylenetetra...

Embodiment 1

[0027] A preparation method for a 5-aminolevulinic acid intercalation LEuH complex may include:

[0028] Step 1, adopt homogeneous precipitation method to synthesize LEuH: 1~2mmol Eu(NO 3 ) 3 ·6H 2 O, 13~26mmolNaNO 3 1-2mmol of hexamethylenetetramine was dissolved in 80-160mL of exhausted water, and nitrogen gas was passed through for 5 minutes, hydrothermally reacted at 90°C for 12-24 hours, then suction filtered, washed with distilled water for 3-4 times, vacuum Dry for 24 hours (dry box model DZF-6020, produced by Shanghai Yiheng Technology Co., Ltd.), so as to prepare LEuH.

[0029] Step 2. According to the molar ratio of NaOH:5-aminolevulinic acid=1.5:1, add NaOH to the aqueous solution of 5-aminolevulinic acid to deprotonate, thereby preparing the sodium salt containing 5-aminolevulinic acid solution.

[0030] Step 3. Disperse 0.05-0.10 g of the LEuH in 75-150 mL of deionized water, add 5-50 mL of a sodium salt solution containing 5-aminolevulinic acid (the content ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
heightaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of a 5-aminolevulinic acid intercalated LEuH complex. The preparation method comprises the following steps: adding NaOH into a water solution of 5-aminolevulinic acid according to a molar ratio of (0.7-1.5):1, and carrying out deprotonation to prepare a sodium salt solution containing 5-aminolevulinic acid; and dispersing the LEuH into deionized water, adding a sodium salt solution containing 5-aminolevulinic acid, carrying out a reaction at 70-100 DEG C for 12-24 hours, and then carrying out washing and drying to prepare the 5-aminolevulinic acid intercalated LEuH complex. The 5-aminolevulinic acid intercalated LEuH complex can be used as a drug carrier of 5-aminolevulinic acid (5-ALA) to effectively protect 5-ALA drug molecules, so that the 5-ALA drug molecules have relatively high stability, fluorescence detection on 5-ALA can be realized, and the effect of a sensitive fluorescent probe is achieved.

Description

technical field [0001] The invention relates to the field of 5-aminolevulinic acid (abbreviated as 5-ALA), in particular to a preparation method of a 5-aminolevulinic acid intercalated LEuH (Layered Eu hydroxides, layered europium hydroxide) complex. Background technique [0002] 5-Aminolevulinic acid is an essential substance for organisms to synthesize chlorophyll, heme, vitamin B12, etc. It is widely used in the fields of agriculture and medicine. The structural formula of 5-aminolevulinic acid is: [0003] [0004] In the field of medicine, 5-aminolevulinic acid has the effect of selectively killing cancer cells. It is called the second generation photodynamic therapy drug. reagent. However, the molecular stability of the 5-ALA drug in the current drug carrier is poor, and the detection and analysis methods for 5-aminolevulinic acid are relatively complicated. Contents of the invention [0005] Aiming at the above-mentioned deficiencies in the prior art, the pres...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/78
CPCC09K11/7729
Inventor 谷庆阳马梦涵
Owner BEIJING INSTITUTE OF PETROCHEMICAL TECHNOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com