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Preparation method of melanin particles

A technology of melanin particles and melanin precursors, which is applied in the field of melanin synthesis, can solve the problems of uneven particle size and irregular spherical structure, and achieves the effects of uniform particle size, good dispersion effect and good ultraviolet absorption effect.

Active Publication Date: 2019-09-13
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The experimental results show that this method can prepare melanin nanoparticles, but the experimental results show that the spherical structure is not very regular, and the particle size is also very uneven (see attached Image 6 ), which limits the application of melanin

Method used

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  • Preparation method of melanin particles
  • Preparation method of melanin particles
  • Preparation method of melanin particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh 0.18g levodopa (Shanghai Aladdin Biochemical Technology Co., Ltd., specification: AR) and dissolve it in 90ml deionized water (the concentration of the aqueous solution containing levodopa is 2mg / ml at this time), add 1mol / L NaOH solution ( Sinopharm Group Chemical Reagent Co., Ltd., specification: AR) is adjusted to system pH and is 7.2, adds 0.06g potassium ferrate (Shanghai McLean Biochemical Technology Co., Ltd., specification: AR), and now the mol ratio of levodopa and oxidant is 1: 0.33, 90°C, after stirring for 6 hours, the reaction ends, slowly add 1mol / L hydrochloric acid solution dropwise to make the system pH≤7. After centrifugal drying, melanin 1 was obtained, with an average diameter of about 78nm.

[0040] combine Figure 2 to Figure 5 It can be seen that both melanin 1 and natural melanin have almost the same infrared characteristic peaks, specifically at 3500-3200cm -1 Occurrence of -OH, -NH 2 And the N-H stretching vibration of the indole struc...

Embodiment 2

[0043]Weigh 0.18g levodopa (Shanghai Aladdin Biochemical Technology Co., Ltd., specification: AR) and dissolve it in 90ml deionized water (the concentration of the aqueous solution containing levodopa is 2mg / ml at this time), add 1mol / L NaOH solution ( Sinopharm Group Chemical Reagent Co., Ltd., specification: AR) is adjusted to system pH and is 8.6, adds 0.06g potassium ferrate (Shanghai McLean Biochemical Technology Co., Ltd., specification: AR), and now the mol ratio of levodopa and oxidant is 1: 0.33, 90°C, after stirring for 5 hours, the reaction ends, slowly add 1mol / L hydrochloric acid solution dropwise to make the system pH≤7. After centrifugal drying, melanin 2 was obtained, with an average diameter of about 50 nm.

[0044] Weigh 5g polycarbonate (DOW Chemical Company, USA, weight average molecular weight is about 30000) in 30g cyclohexanone (Sinopharm Chemical Reagent Co., Ltd., specification: AR), heat and stir to dissolve it completely. Take 0.0025g of melanin 2 p...

Embodiment 3

[0046] Weigh 0.18g of L-tyrosine (Shanghai Aladdin Biochemical Technology Co., Ltd., specification: AR) and dissolve it in 180ml of deionized water (at this time, the concentration of the aqueous solution containing L-tyrosine is 1mg / ml), add 1mol / LNaOH solution (Sinopharm Chemical Reagent Co., Ltd., specification: AR) was adjusted to a system pH value of 8.6, and 0.018 g of potassium ferrate (Shanghai Macklin Biochemical Technology Co., Ltd., specification: AR) was added. At this time, L-tyrosine The molar ratio to the oxidizing agent is 1:0.1, at 90°C, after stirring for 5 hours, the reaction ends, and slowly add 1 mol / L hydrochloric acid solution dropwise to make the system pH≤7. After centrifugal drying, melanin 3 was obtained, with an average diameter of about 30 nm.

[0047] Weigh 5g polycarbonate (DOW Chemical Company, USA, weight average molecular weight is about 30000) in 30g cyclohexanone (Sinopharm Chemical Reagent Co., Ltd., specification: AR), heat and stir to di...

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Abstract

The invention discloses a preparation method of melanin particles. The method comprises the following steps: (1) adding an alkali into a water solution containing a melanin precursor, and adjusting the pH value to be 7-13; (2) adding an oxidizing agent into the system, carrying out heating and stirring to carry out an oxidation reaction on the melanin precursor, and simultaneously promoting a self-polymerization reaction; and (3) ending the reaction, adjusting the pH value of the system to be less than or equal to 7, and carrying out centrifugal drying. The melanin precursor used in the preparation method is low in price, each of the prepared melanin particles is of an obvious spherical shape, and the particle size is uniform. A polymer composite material obtained by compounding the prepared melanin particles with polycarbonate and the like has excellent ultraviolet blocking capability and high cost performance.

Description

technical field [0001] The invention relates to the technical field of melanin synthesis, and furthermore, relates to a preparation method of melanin granules. Background technique [0002] Melanin is a kind of macromolecular compound with irregular structure widely distributed in animals, plants and microorganisms. It is a general term for a class of melanin and brown macromolecular compounds produced during the oxidation and polymerization of phenolic substances. Because the surface of melanin is rich in functional functional groups, it has broad application prospects in cosmetics, hair dyes, UV radiation protection, free radical scavenging, as an amorphous semiconductor, and as a photoprotectant for biopesticides. In addition, melanin is also of great significance to the research of pathology and taxonomy. [0003] However, as a complex polymer, melanin is currently commonly used in two synthetic methods including enzymatic synthesis and chemical synthesis. CN1651574A u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/10C08L69/00C08L77/04C08J5/18
CPCC08G69/10C08J5/18C08J2369/00C08J2477/04
Inventor 东为富王雪飞李婷管鑫王艺杰马丕明陈明清
Owner JIANGNAN UNIV
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