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Polylactic acid/polycaprolactone three-dimensional porous composite monolithic column material and preparation method thereof

A polycaprolactone, three-dimensional porous technology, which is applied in the field of polylactic acid/polycaprolactone three-dimensional porous composite monolithic column material and its preparation, can solve the problems of poor mechanical properties of materials and complex technological processes, and achieve high porosity, Wide application prospects, easy-to-control effects

Inactive Publication Date: 2019-09-10
DONGHUAJINGYUE SUZHOU TEXTILE TECH RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A method for preparing a three-dimensional fluffy porous scaffold. The electrospun membrane of a biodegradable polymer such as polylactic acid is immersed in an alcohol / dry ice mixture, and the electrospun membrane is made fluffy and porous by sublimation and freeze-drying of dry ice, which is beneficial to the growth of cells. Adhesion, growth, and reproduction, but the materials prepared by this method have disadvantages such as poor mechanical properties and complicated process

Method used

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  • Polylactic acid/polycaprolactone three-dimensional porous composite monolithic column material and preparation method thereof
  • Polylactic acid/polycaprolactone three-dimensional porous composite monolithic column material and preparation method thereof
  • Polylactic acid/polycaprolactone three-dimensional porous composite monolithic column material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A polylactic acid / polycaprolactone three-dimensional porous composite monolithic column material is mainly prepared by the following steps:

[0033] (1) Weigh 0.3555g of polylactic acid particles and 0.0395g of polycaprolactone powder with ME104E Mettler-Tolly electronic balance, dissolve in 2mL of dichloromethane, and obtain polylactic acid / polycaprolactone in a steady state blended solution;

[0034] (2) Under the stirring of a magnetic stirrer, add 1.5 mL of n-hexane dropwise to the cloud point in the polylactic acid / polycaprolactone blend solution, so that the polymer solution system changes from a stable state to a metastable state;

[0035] (3) Stand still for 24 hours at 25°C to obtain a wet bulk material and take it out;

[0036] (4) Submerge the bulk material in methanol and place it on a shaker to vibrate, replace the methanol solution every once in a while, take it out after several times, and dry it in vacuum at room temperature for 3 hours to obtain a poro...

Embodiment 2

[0038] A polylactic acid / polycaprolactone three-dimensional porous composite monolithic column material is mainly prepared by the following steps:

[0039] (1) Weigh 0.316g of polylactic acid particles and 0.072g of polycaprolactone powder with ME104E Mettler-Tolly electronic balance, dissolve in 2mL of dichloromethane, and obtain polylactic acid / polycaprolactone in a steady state blended solution;

[0040] (2) Under the stirring of a magnetic stirrer, add 1.5 mL of n-hexane dropwise to the cloud point in the polylactic acid / polycaprolactone blend solution, so that the polymer solution system changes from a stable state to a metastable state;

[0041] (3) Stand still for 24 hours at 25°C to obtain a wet bulk material and take it out;

[0042] (4) Submerge the bulk material in anhydrous methanol and place it on a shaker to vibrate, replace the methanol solution every once in a while, take it out after several times, and dry it in vacuum at room temperature for 3 hours to obtai...

Embodiment 3

[0044] A polylactic acid / polycaprolactone three-dimensional porous composite monolithic column material is mainly prepared by the following steps:

[0045] (1) Weigh 0.2765g of polylactic acid granules and 0.1185g of polycaprolactone powder with ME104E Mettler-Tolly electronic balance, dissolve in 2mL of dichloromethane to obtain polylactic acid / polycaprolactone in a steady state blended solution;

[0046] (2) Under the agitation of a magnetic stirrer, add 1.4 mL of n-hexane dropwise to the cloud point in the polylactic acid / polycaprolactone blend solution, so that the polymer solution system changes from a stable state to a metastable state;

[0047] (3) Stand still for 24 hours at 25°C to obtain a wet bulk material and take it out;

[0048] (4) Submerge the bulk material in anhydrous methanol and place it on a shaker to vibrate, replace the methanol solution every once in a while, take it out after several times, and dry it in vacuum at room temperature for 3 hours to obtai...

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Abstract

The invention provides a polylactic acid / polycaprolactone three-dimensional porous composite monolithic column material and a preparation method thereof. The preparation method comprises the followingsteps: dissolving a certain amount of polylactic acid and polycaprolactone into a good solvent of the polylactic acid and the polycaprolactone; adding a certain amount of a poor solvent into the polylactic acid / polycaprolactone mixed solution to a cloud point to make the system change from a steady state to a metastable state; allowing the metastable-state system to stand until the polylactic acid / polycaprolactone solution spontaneously forms a three-dimensional pass-through porous structure to obtain a wet bulk material; and performing replacement, performing vacuum low-pressure drying to make the polylactic acid / polycaprolactone solidified to form the porous composite monolithic column material. The three-dimensional porous composite monolithic column material prepared by the technicalsolution provided by the invention has the advantages of excellent rapid mass transfer performance and chemical stability, a large specific surface area, easy chemical modification, no toxicity and biodegradability, meets the requirements of ecology and environment protection, and can be widely used in the fields of oil absorption, biomedical applications, drug controlled release, catalyst carriers, tissue engineering and the like.

Description

technical field [0001] The invention relates to the field of natural polymer material processing, in particular to a polylactic acid / polycaprolactone three-dimensional porous composite monolithic column material and a preparation method thereof. Background technique [0002] Polylactic acid and polycaprolactone have good biodegradability and biocompatibility. They are ideal green polymer materials and are often used as support materials for cell growth. However, polylactic acid has poor flexibility and polycaprolactone The low mechanical strength of ester limits the application of both due to the defects in mechanical properties. [0003] At present, polylactic acid and polycaprolactone porous materials are widely used in biomedicine, tissue engineering, oil absorption and other fields. Common preparation methods for porous materials include freeze-drying, porogen, supercritical CO 2 Foaming method and 3D printing technology, etc. A preparation method of biodegradable bio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08J9/28
CPCC08J9/0061C08J9/28C08J2201/0502C08J2367/04C08J2467/04
Inventor 孙晓霞陈明镜王新厚
Owner DONGHUAJINGYUE SUZHOU TEXTILE TECH RES CO LTD
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