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Water-absorbent antibacterial dressing for burn injuries and wounds and preparation method and application thereof

A wound and antibacterial agent technology, which is applied in the field of water-absorbing polymer hydrogel antibacterial dressings for infectious wounds, can solve the problems of poor therapeutic effect of infectious wounds, clinical application of silver toxicity, and limited antibacterial effect, etc., to achieve good elasticity, The effect of high strength and stable structure

Active Publication Date: 2019-08-23
非零和(北京)投资管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some wound dressings are clinically used, such as commercial dressings such as Syvek-Patch, Chitopack C, Tegasorb, HemCon Bandage, and KytoCel, the antibacterial effect is limited, and the effect on infected wounds is not good.
Although nano-silver dressings have broad-spectrum antibacterial effects, the toxicity of silver itself limits its clinical application.

Method used

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  • Water-absorbent antibacterial dressing for burn injuries and wounds and preparation method and application thereof
  • Water-absorbent antibacterial dressing for burn injuries and wounds and preparation method and application thereof
  • Water-absorbent antibacterial dressing for burn injuries and wounds and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Preparation of water-absorbing burn wound antibacterial dressing sample 1

[0051] Using methacrylic anhydride (MAA)-capped polyethylene glycol (PEG) as a crosslinking agent, sodium polyacrylate as a water-absorbing polymer, MAA-capped cyclodextrin as an antibacterial slow-release carrier, and MAA-capped chitosan ( MAACTS) reaction, prepare chitosan derivative resin, load broad-spectrum antibacterial function fungicide iodine, its synthesis process is as follows:

[0052]

[0053] Step 1: Preparation of Backbone Compounds

[0054] Add 3 ml of methacrylic anhydride to 100 ml of chitosan solution with a volume fraction of 2%, and mechanically stir for 120 min at a stirring speed of 500 to 1500 red / min. Methacrylic anhydride-terminated chitosan (MAACTS) was obtained.

[0055] Step 2: Preparation of Crosslinker

[0056] Add 5g of PEG-6000 into 50ml of chloroform, stir magnetically for 30min, add 5ml of methacrylic anhydride, stir magnetically for 6h, volatil...

Embodiment 2

[0063] Example 2 Preparation of water-absorbing burn wound antibacterial dressing sample 2

[0064] Step 1: Add 15ml of 2wt% maleic anhydride (dimethyl sulfoxide as solvent) into 100ml of chitosan solution with a volume fraction of 2%, and mechanically stir for 120min at a stirring speed of 500-1500red / min. Maleic anhydride-terminated chitosan (MCTS) was obtained.

[0065] Step 2: Add 5g of PEG-6000 into 50ml of chloroform, stir magnetically for 30min, add 5g of maleic anhydride, stir magnetically for 6h, volatilize the chloroform, and obtain maleic acid-capped PEG-6000 white powder.

[0066] Step 3: Add 1g of β-cyclodextrin to 50ml of acrylic acid, stir magnetically for 10min, add 15ml of 2wt% maleic anhydride (dimethyl sulfoxide as solvent), and stir magnetically for 6h to obtain maleic acid-terminated β-cyclodextrin Dextrin solution.

[0067] Step 4: Add 50g NaOH to 300ml deionized water in a salt ice bath, and stir mechanically. When the NaOH solution dropped to 0°C, ad...

Embodiment 3

[0071] Example 3 Preparation of water-absorbing burn antibacterial dressing sample 3

[0072] Step 1: Add 5ml of 2wt% itaconic anhydride (dimethyl sulfoxide as solvent) into 100ml of chitosan solution with a volume fraction of 2%, and mechanically stir for 120min at a stirring speed of 500-1500red / min. Itaconic acid-terminated chitosan (ICTS) was obtained.

[0073] Step 2: Add 5g of PEG-6000 to 50ml of chloroform, stir magnetically for 30min, add 5g of itaconic anhydride, stir magnetically for 6h, volatilize the chloroform, and obtain PEG-6000 powder capped with itaconic acid.

[0074] Step 3: Add 1 g of β-cyclodextrin to 50 ml of acrylic acid, stir magnetically for 10 min, add 5 ml of 2 wt% itaconic anhydride (dimethyl sulfoxide as solvent), and stir magnetically for 6 h to obtain itaconic acid-capped β-cyclodextrin Dextrin solution.

[0075] Step 4: Add 50g NaOH to 100ml deionized water in a salt ice bath, and stir mechanically. When the NaOH solution dropped to 0°C, add ...

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Abstract

Provided are a water-absorbent antibacterial dressing for burn injuries and wounds and a preparation method and application thereof. The dressing is a stereoscopic reticular porous sponge, chitosan isadopted as a framework, a super absorbent polymer combined with an antibacterial agent control-released carrier is adopted as branched chains, and macromolecules or polymers of flexiblestructures areadopted as a cross-linking agent among the branched chains. The antibacterial agent control-released carrier is loaded with an antibacterial agent. The weight ratio of the chitosan to the super absorbent polymer to the antibacterial agent control-released carrier to the cross-linking agent to the antibacterial agent in the antibacterial dressing is (0.6-2):(40-60):(0.6-25):(0.1-10):(1-10). The dressing has water absorption performance, moisture retention performance, air permeability, a barrier property, a long-acting antibacterial property, a bleeding stopping function and high strength andis easy to tear off, and is a novel antibacterial compound dressing with a broad-spectrum antibacterial effect. The dressing can be prepared through a one-pot method, is simple in preparation process,low in cost, prominent in treatment effect and high in safety and has remarkable medical value and industrialization potential.

Description

technical field [0001] The invention relates to a liquid-absorbing, moisturizing, antibacterial and healing-promoting biological material, in particular to a water-absorbing polymer hydrogel antibacterial dressing for infectious wounds. Background technique [0002] The skin, the largest organ of the human body, not only maintains metabolism by preventing water evaporation, but also plays an important role in protecting against harmful environments such as ultraviolet rays, chemicals and foreign microorganisms. However, trauma, burns, etc. often lead to tissue cell necrosis, and the defense function of the skin is destroyed. Wound infection is the most common complication and the main cause of delayed healing. External medicine for the treatment of burn wounds has the characteristics of many times of medication and large dosage, which often causes local or systemic toxic and side effects, and even damages internal organs. Burn wounds are often large in size, accompanied by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/28A61L15/24A61L15/46
CPCA61L15/24A61L15/28A61L15/425A61L15/46A61L2300/404A61L2300/406C08L5/08
Inventor 柴家科钱智勇沈显贵王雨薇
Owner 非零和(北京)投资管理有限公司
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