Radio frequency response thermosensitive nano-composite embolization material and preparation and application methods thereof

Abstract

The invention discloses a radio frequency response thermosensitive nano-composite embolization material and preparation and application methods thereof. The radio frequency response thermosensitive nano-composite embolization material is in a core-shell structure composed of a radio frequency response nano material core and thermosensitive nano polymers with the molecular chains modified onto thesurface of the core. The preparation method of the radio frequency response thermosensitive nano-composite embolization material comprises weighing out and mixing thermosensitive nano polymer freeze-dried powder with radio frequency response nano materials for self-assembly reaction, performing ultrafiltration and centrifugation, and then collecting and freeze-drying concentrated solution to obtain the radio frequency response thermosensitive nano-composite embolization material. With the characteristic of radio frequency response, the radio frequency response thermosensitive nano-composite embolization material can improve the thermal deposition efficiency and distribution of abundant blood supply tumor areas, give full play to the multiple chemotherapeutic sensitizing effects of thermaltherapy and achieve the synergistic effects of radio frequency thermal therapy, chemotherapy and vascular embolization; the radio frequency response thermosensitive nano-composite embolization material can serve as an embolization agent for embolotherapy as well as a radio frequency response material, achieve intraoperative X-ray developing and long-term postoperative X-ray re-examination, and accordingly have a broad application prospect in the fields such as nanomedicine, disease diagnosis and tumor treatment.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and in particular relates to a radio frequency response temperature-sensitive nanocomposite embolic material and its preparation method and application. Background technique [0002] Due to its insidious onset, rapid invasion and metastasis, and high degree of malignancy, primary liver cancer has become one of the most serious public health problems in my country, and its 5-year survival rate is less than 5%. The clinical efficacy is very limited. At present, interventional therapy is one of the most important treatment methods for advanced liver cancer; in particular, transarterial chemoembolization (TACE) can achieve targeted delivery of vascular embolism agents and chemotherapy drugs in peripheral arteries through superselective perfusion (one of the most efficient targeting strategies), and is recommended as the preferred interventional therapy for liver cancer. [0003] Howe...

AI Technical Summary

Problems solved by technology

In particular, the recently developed RF-responsive nanomaterials (such as gold nanoclusters, carbon nanotubes, graphene, cobalt nanoparticles, etc.) utilize the excellent tissue penetration ability of RF electromagnetic waves to achieve efficient thermal deposition and selective heating of deep tumors. Tumor cells, which are expected to improve the shortcomings of traditional RFA liver cancer treatment, such as small ablation area, poor synergy with chemotherapy, and non-selective damage to adjacent normal tissue cells.

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