Duck adenovirus type-3 virus strain and yolk antibody preparation and application thereof

Abstract

The invention discloses a duck adenovirus type-3 virus strain and yolk antibody preparation and application thereof. The duck adenovirus type-3 virus strain is produced by a duck adenovirus type-3 virus GD06 strain immune poultry with the preservation number being CCTCC NO:V201905. The virus strain has the good specificity and immunogenicity. The yolk antibody of the adenovirus type-3 is high in safety, infection of the duck adenovirus type-3 is effectively prevented, the immunity protecting rate is high, and the duck adenovirus type-3 is effectively treated; the virus strain can be used for detecting duck adenovirus type-3 virus and has the wide application prospect.

Description

Technical field [0001] The invention belongs to the field of animal antigen and antibody, in particular the preparation and application of a duck adenovirus type 3 virus strain and its egg yolk antibody. Background technique [0002] Fowl adenovirus is a common infectious disease of poultry and wild fowl. In recent years, duck adenovirus type 3 (DAdV-3) has spread widely in my country. After being infected with duck adenovirus type 3, muscovy ducks will have liver enlargement, paleness, splenomegaly, congestion and other symptoms. The mortality rate of this disease can reach more than 50%, causing huge losses to the duck industry. In recent years, the prevalence of duck adenovirus type 3 has shown an outbreak trend, seriously jeopardizing the development of the duck industry. [0003] Duck adenovirus type 3 currently has no effective prevention and control methods, but there are research reports on inactivated vaccines. However, such vaccines are still in the scientific research ...

AI Technical Summary

Problems solved by technology

[0003] There is currently no effective prevention and control method for duck adenovirus type 3, but there are research reports on inactivated vaccines, but such vaccines are still in the scientific research stage and are still No successful reports and products produced

At the same time, the existing research has the following problems: First, the infection model design is unreasonable. Ducks infected with the virus did not show typical symptoms, the virus was not detected in various tissues, and the ducks did not show death symptoms, which was different from the clinical data; It is because ducks cannot produce effective antibodies in a short period of time after being vaccinated with inactivated vaccines, and even if they produce antibodies in a short period of time, the protection rate against the virus is low, so it is not suitable for ducks less than 2 weeks old

[0004] At present, there is no effective duck adenovirus type 3 animal infection model, and there is no prevention and treatment for duck adenovirus type 3. A new duck adenovirus type is urgently needed The strain of adenovirus type 3 as animal evaluation model and the safe and effective yolk antibody produced by it

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