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Strong-toughness and anti-fouling dual-network hydrogel and preparation method thereof

A dual-network, hydrogel technology, applied in the field of polymer hydrogels, can solve the problems of lack of biocompatibility, anti-protein non-specific adsorption performance, etc., achieve good biocompatibility, and be conducive to large-scale industrial production , the effect of simple operation steps

Active Publication Date: 2019-07-05
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to overcome the problems of lack of biocompatibility and anti-protein non-specific adsorption performance of traditional double network hydrogel, the present invention provides a strong and anti-fouling double network with excellent mechanical properties, anti-fouling and anti-bacterial properties and good biocompatibility Hydrogels

Method used

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  • Strong-toughness and anti-fouling dual-network hydrogel and preparation method thereof
  • Strong-toughness and anti-fouling dual-network hydrogel and preparation method thereof
  • Strong-toughness and anti-fouling dual-network hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Add 0.71g (1.0M) of N-hydroxyethylacrylamide (HEAA) and 0.36g of sodium alginate (SA) with a molecular viscosity of 180mPa.s (1%, 2°C) into 6mL of deionized water, Add 0.2 mol% (relative to HEAA) N,N-methylenebisacrylamide (MBAA) and 1 mol% (relative to HEAA) ammonium persulfate, and stir for 20 minutes to obtain a uniform mixed solution;

[0040] (2) Nitrogen gas was passed into the above mixed solution for 10 minutes, sonicated for 30 minutes under the condition of 80W ultrasonic power, and centrifuged at 7500rpm for 5 minutes;

[0041] (3) Inject the mixed solution treated in step (2) into a sealed glass mould, react at 50°C for 6h under a nitrogen atmosphere, and obtain a covalently crosslinked network after the reaction; during the reaction, the N- Hydroxyethylacrylamide forms a covalent crosslinked network through chemical crosslinking, and free sodium alginate molecules are uniformly embedded in the covalent crosslinked network;

[0042] (4) Put the covalent...

Embodiment 2

[0045] (1) Add 1.07g (1.5M) of N-hydroxyethylacrylamide (HEAA) and 0.36g of sodium alginate (SA) with a molecular viscosity of 220mPa.s (1%, 2°C) into 6mL of deionized water, Add 0.2 mol% (relative to HEAA) N,N-methylenebisacrylamide (MBAA) and 1 mol% (relative to HEAA) ammonium persulfate, and stir for 20 minutes to obtain a uniform mixed solution;

[0046] (2) Nitrogen gas was passed into the above mixed solution for 10 minutes, sonicated for 50 minutes under the condition of 300W ultrasonic power, and centrifuged at 7500rpm for 5 minutes;

[0047] (3) Inject the mixed solution treated in step (2) into a sealed glass mould, react at 50°C for 6h under a nitrogen atmosphere, and obtain a covalently crosslinked network after the reaction; during the reaction, the N- Hydroxyethylacrylamide forms a covalent crosslinked network through chemical crosslinking, and free sodium alginate molecules are uniformly embedded in the covalent crosslinked network;

[0048] (4) Put the covalen...

Embodiment 3

[0051] (1) Add 1.43g (2.0M) N-hydroxyethylacrylamide (HEAA) and 0.36g sodium alginate (SA) with a molecular viscosity of 200mPa.s (1%, 2°C) into 6mL deionized water, Add 0.2 mol% (relative to HEAA) N,N-methylenebisacrylamide (MBAA) and 1 mol% (relative to HEAA) ammonium persulfate, and stir for 20 minutes to obtain a uniform mixed solution;

[0052] (2) Introduce nitrogen gas into the above mixed solution for 30 minutes, sonicate for 40 minutes under the condition of 300 W ultrasonic power, and centrifuge at 7000 rpm for 8 minutes;

[0053] (3) Inject the mixed solution treated in step (2) into a sealed glass mold, react at 45°C for 6h under nitrogen atmosphere, and obtain a covalently crosslinked network after the reaction; during the reaction, the N- Hydroxyethylacrylamide forms a covalent crosslinked network through chemical crosslinking, and free sodium alginate molecules are uniformly embedded in the covalent crosslinked network;

[0054] (4) Put the covalent cross-linke...

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Abstract

The invention relates to the technical field of polymeric hydrogels and provides a strong-toughness and anti-fouling dual-network hydrogel and a preparation method thereof in order to solve the problem and defect that a traditional dual-network hydrogel is lack of biocompatibility and anti-protein non-specific adsorption property. The strong-toughness and anti-fouling dual-network hydrogel is prepared by chemically crosslinking N-hydroxyethyl acrylamide to form a covalent cross-linked network firstly, and then, forming physical crosslinking under a coordination effect of sodium alginate and multivalent cations interspersed in the covalent cross-linked network. The strong-toughness and anti-fouling dual-network hydrogel provided by the invention is excellent in mechanical properties and good in anti-fouling and antibacterial properties as well as biocompatibility so as to have a potential application prospect in the biomedical field; and the preparation method is simple in operation step, mild and easily-controlled in condition, free of specific requirements for equipment and beneficial to large-scale industrial production.

Description

technical field [0001] The invention relates to the technical field of polymer hydrogel, in particular to a strong and antifouling double network hydrogel and a preparation method thereof. Background technique [0002] As a class of "squishy" polymer materials with a three-dimensional structure, hydrogels have attracted great attention in the fields of industry, materials, biology, and medicine. However, the practical applications of conventional hydrogels are often limited by their poor mechanical properties. [0003] Currently, a variety of hydrogels with excellent mechanical properties have been developed, for example, double network hydrogels, nanocomposite hydrogels, topology hydrogels, conformational transition hydrogels, macromolecular microsphere hydrogels Wait. The most typical of these is the double network hydrogel (DN gel) composed of a brittle first network and a flexible second network. The first network composed of rigid chains in the double-network hydroge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/24C08L5/04C08J3/075C08F220/58C08F222/38
CPCC08F220/58C08J3/075C08J2333/24C08J2405/04C08F222/385
Inventor 张静陈丽群冯杰
Owner ZHEJIANG UNIV OF TECH
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