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Nano channel type natural controlled-release carrier material and preparation method thereof

A technology of nano-pores and carrier materials, applied in the fields of botanical equipment and methods, chemicals for biological control, pharmaceutical formulations, etc., can solve the problems of industry development restrictions, waste water pollution, high production costs, and avoid decomposition or loss. , to ensure the safety of medication, to ensure long-term effect

Active Publication Date: 2019-07-05
XIAMEN UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, problems such as poor sustained and controlled release effects, toxicity and safety issues, or high production costs have plagued the development of the industry. Cost-effective, safe and efficient sustained and controlled release carriers are still the biggest bottleneck in the development of sustained and controlled release drugs
Therefore, the traditional chitin extraction process has the problems of large material consumption and energy consumption, serious waste water pollution, high production cost, poor enterprise benefit, production is restricted by the environment, and it is difficult to produce on a large scale.
Therefore, the global annual output of chitin and its derivative chitosan is less than 200,000 tons, and the development of the industry is greatly restricted.

Method used

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  • Nano channel type natural controlled-release carrier material and preparation method thereof
  • Nano channel type natural controlled-release carrier material and preparation method thereof
  • Nano channel type natural controlled-release carrier material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Example 1 Preparation of chitin-protein composite bio-based material with shrimp shells

[0095] First rinse the shrimp shells and dry them at 160°C, take them out and add them to a single-necked flask equipped with an electric stirrer, and prepare a citric acid solution with a concentration of 10%, wherein the mass ratio of the shrimp shells to the citric acid solution is 1:10, Heating to 50°C, heat preservation treatment for 4 hours to decalcify, select warm water at 50°C to filter through a mesh sieve, recover the calcium citrate in the filtrate, and perform secondary decalcification on the obtained filtrate according to the same experimental conditions, and finally use Filter through a mesh sieve, rinse the filtrate with an appropriate amount of distilled water for several times until it becomes neutral, and after drying, grind it to 200 mesh with a pulverizer to obtain the chitin-protein composite bio-based material. Dry again to constant weight and set aside. Ref...

Embodiment 2

[0096] Embodiment 2 prepares chitosan-calcium carbonate composite bio-based material with shrimp shell

[0097] Add 150.0g of shrimp shell powder to a three-necked flask equipped with an electric stirrer, mix and dissolve 80.0g of potassium hydroxide solid with 40.0g of water, add 400mL of isopropanol, stir evenly, pour into a three-necked flask, React at low temperature for 3.0h, fully hydrolyze the protein and remove acetyl groups, filter, stir the obtained solid with 200mL isopropanol at room temperature for 0.5h, filter, wash with water three times, and dry to constant weight to obtain chitosan - Calcium carbonate composite bio-based material. The protein hydrolyzate obtained by filtration contains amino acids, small peptides and potassium hydroxide. After recycling the isopropanol solvent, it can be used as a raw material for liquid amino acids and potassium fertilizers. Measure the degree of deacetylation by acid-base titration or infrared spectroscopy, dissolve chitosa...

Embodiment 3

[0098] Embodiment 3 prepares calcium carbonate crude product with shrimp shell

[0099] Add 150.0g of shrimp shell powder to a three-necked flask equipped with an electric stirrer, mix and dissolve 80.0g of potassium hydroxide solid with 40.0g of water, add 400mL of isopropanol, stir evenly, pour into a three-necked flask, and reflux React for 3.0 hours, fully hydrolyze the protein and remove the acetyl group, then add 25.0g of chloroacetic acid, add in 5 times, react for 3.0 hours under the condition of 60 ℃ heat preservation, carry out carboxymethylation on chitosan, filter and separate to obtain carboxymethyl A mixture of chitosan and calcium carbonate, the mixture is dissolved in water, filtered to obtain the by-product porous calcium carbonate. The filtrate can be added with 80% ethanol to reverse precipitate the carboxymethyl chitosan product.

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Abstract

The invention relates to a nano channel type natural controlled-release carrier material and a preparation and application methods thereof. Shrimp and crab shells and other products with natural nanochannels are used as the carriers, and the series of functional chemical substance controlled-release carriers with natural nano channels are produced directly or through a coproduction process. Researches discover that the micro-channels with the average pore diameter being about 10 nanometers can effectively store and release various functional substances in a controlled manner, and rich novel carrier product series and flexible combination are provided to satisfy the performance requirements of various controlled-release products. The preparation method is wide in biomass raw material source and cheap, and the produced carriers can satisfy the cost performance requirements of simpleness, high efficiency, greenness and safety. The preparation method can promote the application of controlled-release medicine, pesticides and plant growth regulators and controlled availability fertilizer, the pesticides and fertilizer can be prevented from being decomposed by enzymes or microorganism and from losing by the protection of the nano channels which the microorganisms cannot enter, and a novel efficient, long-acting, safe and cheap animal and plant pesticide and fertilizer system is developed.

Description

technical field [0001] The invention belongs to the field of development, production and application of drug sustained and controlled release materials, in particular to the field of preparation and application of green and safe carriers filled with drugs, fertilizers and other functional chemical substances. Invented a carrier with natural nanopores and a simple preparation method using natural biomass such as shrimp and crab shells as raw materials. Background technique [0002] The slow and controlled release carrier refers to the material that can control the automatic release of functional components at a certain speed within a predetermined time to maintain its effective concentration, and can be widely used in animals, plants and microorganisms. Among them, the most important is the slow and controlled release of drugs that can control the speed, time and location of drug release, and drug slow release carriers can change the way and distribution of drugs into animals...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/36A61K47/46A61K47/02A61K31/192A61K33/14A01N25/10A01N43/90A01N57/20A01N51/00A01P7/04A01P13/00
CPCA01N25/10A01N43/90A01N51/00A01N57/20A61K31/192A61K33/14A61K47/02A61K47/36A61K47/42A61K47/46
Inventor 尹应武李金萍杨少梅廖翠莺吐松叶李艺倪锋赵玉芬
Owner XIAMEN UNIV
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