Method for preparing biocompatible coating controllable core-shell type magnetic particles

Abstract

The invention belongs to the technical field of magnetic particle preparation, and discloses a method for preparing biocompatible coating controllable core-shell type magnetic particles. The method comprises the following steps: anchoring methylacrylic acid to the Fe3O4 particle surface through a simple coordination reaction between methylacrylic acid MAA and unsaturated iron ions on the Fe3O4 nano-particle surface to form a polymerizable structure Fe3O4-MAA; adding konjac glucomannan, methylacrylic acid, a crosslinking agent, initiator and template, directly polymerizing through a graft copolymerization method to form coating controllable core-shell type magnetic particles with biocompatibility. The method is simple in process and low in cost, and the product can be used in carriers of target magnetic field drug release materials, magnetic resonance imaging contrast agents, magnetic molecularly imprinted polymer and the like.

Description

technical field [0001] The invention belongs to the technical field of magnetic particle preparation, and in particular relates to a method for preparing core-shell magnetic particles with controllable biocompatibility coating. Background technique [0002] At present, the commonly used existing technologies in the industry are as follows: magnetic nanoparticles with a core / shell structure have broad application prospects, and they are widely used in the fields of magnetic separation, biosensors, bioimaging and drug release. For example, superparamagnetic nanoparticles with a core / shell structure can be made into magnetic molecularly imprinted polymers (a highly cross-linked polymer prepared in the presence of template molecules. After the template is removed, it has specific molecular Selective recognition and separation function) is used to selectively recognize or separate target molecules. After it completes the recognition and enrichment of target molecules, it can be e...

AI Technical Summary

Problems solved by technology

[0003] However, there are these problems in the use of these materials: (1) when preparing magnetic nano-hydrogel materials, generally magnetic nanoparticles such as Fe 3 o 4 The particles are directly dispersed in the polymer precursor solution and then polymerized, which is actually a kind of blending effect. This operation is very likely to cause uneven dispersion, and some magnetic particles are not actually wrapped.

Highly controllable core / shell structures are difficult to achieve due to the uncontrollable nature of blending or polymerization at its surface

(3) In addition, because a large number of synthetic monomers are used to polymerize on its surface, or blended with synthetic polymers, the biocompatibility of the resulting material is poor, and if the magnetic material is used in the body, it has better biocompatibility Sex is the prerequisite for its large-scale application

[0004] In summary, the existing problems in the prior art are: the thickness of the shell layer of the current core / shell magnetic materials cannot be adjusted, and the biocompatibility is poor

[0005] The difficulty and significance of solving the above technical problems: the traditional blending method cannot realize the controllable shell of core / shell magnetic materials, which can easily lead to uneven shell or part of the core structure exposed

In addition, due to the use of a large number of synthetic monomers as the shell material, its biocompatibility cannot be guaranteed, thus limiting its application in the field of biomedicine

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