Device for uniformly mixing liquid preparation, and application thereof

A liquid preparation and mixing technology, which is applied to mixers, mixers with rotating stirring devices, and dissolution, etc. It can solve the problems of high labor intensity, shaking plate strength and the effect of mixing methods, and achieve reliable performance and easy operation. convenient effect

Active Publication Date: 2019-06-25
HEHUANG PHARMA SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is labor-intensive, and each person will have a greater impact on the mixing effect due to the different strength and method of shaking the plate. Therefore, it is necessary to study and design a device for mixing liquid preparations to replace manual shaking. disk operation

Method used

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  • Device for uniformly mixing liquid preparation, and application thereof
  • Device for uniformly mixing liquid preparation, and application thereof
  • Device for uniformly mixing liquid preparation, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] The inner car 11 is matched with the two side outer guide rails 121 on the tank car 12 through the track wheels 113, thereby being installed on the tank car 12. Toggle the interlock switch 13 located in the middle of the outer guide rails 121 on both sides. The interlock switch 13 is a sheath-type mechanical interlock switch. Limiting clamping between the second sheath parts on the tanker 12 prevents the inner vehicle 11 from moving back and forth on the tanker 12 and prevents the inner vehicle 11 from sliding down from the tanker 12. Take the liquid preparation and put it into multiple turnover trays respectively. The liquid preparation is Shengmai Injection adding a surfactant as a solubilizer. The surfactant is polysorbate-80. 270 ml ampoules per plate. Open the net fence 112 at one end of the inner car 11, and then put a plurality of turntables into a plurality of layered brackets 111 in the inner car 11, and set up cushions between adjacent turntables, thereby wea...

Embodiment 2

[0150] Comparing Example 1 with the mixing method of Reference Document 1, it can be seen that the present invention adopts equipment mixing, which not only saves labor; and can simultaneously load a plurality of turnover discs such as 36 discs on the inner car, and the production efficiency is obviously improved; The turntable rotates synchronously, the shaking plate is stable, and the consistency of the mixed liquid is good. It can be seen that using this device for automatic rotation is obviously better than manual shaking operation.

[0151] In summary, the invention provides a kind of equipment for mixing liquid preparations and its application, which uses automatic rotating mechanical equipment to replace the manual shaking plate operation, can realize multi-disk product mixing, and is convenient to operate and has excellent performance. Reliable, safe and stable, it is worth popularizing and applying. Therefore, the present invention effectively overcomes various short...

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PUM

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Abstract

The present invention provides a device for uniformly mixing a liquid preparation. The device comprises a sample introduction mechanism and a mixing mechanism, the sample introduction mechanism includes an inner vehicle for storing the liquid preparation, the mixing mechanism includes a rotating cage, and the rotating cage is matched with the inner vehicle to rotationally mix the liquid preparation stored in the inner vehicle. The invention further provides a using method of the device for uniformly mixing the liquid preparation. An automatic rotating machine is used to replace manual wobble plate operation, so the device can realize multi-plate uniform product mixing, also has the advantages of convenience in operation, reliable performances, and good safety and stability, and is very worth promoting.

Description

technical field [0001] The invention belongs to the technical field of mixing liquid preparations, and relates to a device for mixing liquid preparations and its application, in particular to a device for mixing suspensions or emulsions and its application. Background technique [0002] The liquid preparation injection is added a certain amount of surfactant polysorbate-80 as a solubilizer according to the requirements of the process formula. After reaching 93°C (sun point), the hydrogen bond formed between polysorbate-80 and water in its aqueous solution breaks, and the solubility of polysorbate-80 drops sharply and precipitates, forming layers (similar to sugar dissolution), although cooling Afterwards, this process is reversible, but the natural re-dissolving process is extremely slow. In this state, the stability of the product may be affected, and the layered product will be misjudged as unqualified when using a fully automatic light inspection machine for visible forei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F7/02B01F15/00B01F15/02
Inventor 左斌从建东卢明梁思惠
Owner HEHUANG PHARMA SHANGHAI
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