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Application of anoectochilus roxburghii extract in preparation of drug for preventing and/or treating D-galactosamine-induced acute liver injury of mice

A technology for acute liver injury and galactosamine, which is applied in the field of medicine and can solve the problems of less research on the protective effect of liver injury

Inactive Publication Date: 2019-06-25
SHANDONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no more specific drugs that can significantly reduce liver damage and promote liver cell regeneration, and traditional Chinese medicine is even rarer, and there are few studies on its protective effect on liver injury at home and abroad

Method used

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  • Application of anoectochilus roxburghii extract in preparation of drug for preventing and/or treating D-galactosamine-induced acute liver injury of mice
  • Application of anoectochilus roxburghii extract in preparation of drug for preventing and/or treating D-galactosamine-induced acute liver injury of mice
  • Application of anoectochilus roxburghii extract in preparation of drug for preventing and/or treating D-galactosamine-induced acute liver injury of mice

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Experimental program
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Effect test

Embodiment 1

[0041] 1 material

[0042] 1.1 Drugs and reagents

[0043] Clematis aureus, purchased from Fuzhou Jialeda Biological Engineering Co., Ltd. (sample number: (180628) Y2895); D-Gal, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.; alanine aminotransferase (Alanine transaminase, ALT) , Aspartate aminotransferase (Aspartate aminotransferase, AST) and lactate dehydrogenase (lactatedehydrogenase, LDH) detection kits were purchased from Ningbo Meikang Biotechnology Co., Ltd. Malondialdehyde (Malondialdehyde, MDA) and the ability to inhibit hydroxyl radical kit were purchased from Nanjing Jiancheng Bioengineering Institute.

[0044] 1.2 Animals

[0045] Kunming mice were purchased from the Animal Experiment Center of Shandong University, and the experimental animal production license number is SCXK (Lu) 20130009. The certificate number for the use of experimental animals is SYXK (Lu) 20150015, and the production license for experimental animal feed is SCXK (Beijing)...

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Abstract

The invention provides an application of an anoectochilus roxburghii extract in preparation of drug for preventing and / or treating D-galactosamine-induced acute liver injury of mice and belongs to thetechnical field of medicines. Experiments prove that the anoectochilus roxburghii extract can remarkably improve D-galactosamine-induced acute liver injury symptoms for the first time, the specific performance is that the necrosis areas of liver cells of mice are obviously decreased, inflammatory cell infiltration, ballooning and fatty degeneration of liver cells are alleviated, the lobular structure of liver tends to be regular, and the arrangement of hepatic cords are regular and tidy. In terms of biochemical indexes, the anoectochilus roxburghii extract can obviously reduce the increased activity of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and malondialdehyde due to the D-galactosamine-induced acute liver injury. A foundation is laid for further development and utilization of anoectochilus roxburghii as a natural medicine raw material, in particular as a drug for preventing and / or treating liver diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of a clematis extract in the preparation of medicines for preventing and / or treating acute liver injury in mice induced by D-galactosamine. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] D-Galactosamine (D-Gal) is an interfering agent of uridine phosphate in liver cells. The pathological and morphological characteristics of the liver tissue of this model are very similar to those of human viral hepatitis, and it can be a good model of human virus. Symptoms of hepatitis. Commonly used chemicals that cause animal liver damage have carbon tetrachlor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P1/16
Inventor 张翠丽岳敏曹雯熊若谷陈方舟汤皓晴赵秀兰
Owner SHANDONG UNIV
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