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Skin whitening composition containing mannosylerythritol lipid

A skin whitening and composition technology, applied in the field of skin whitening compositions, can solve the problems of use limitation, insufficient whitening effect, stable skin safety, etc., and achieve the effect of easy preparation and improvement of overall skin color

Pending Publication Date: 2019-06-21
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, their use is limited due to insufficient whitening effects and problems with stability within dosage forms and safety to the skin

Method used

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  • Skin whitening composition containing mannosylerythritol lipid
  • Skin whitening composition containing mannosylerythritol lipid
  • Skin whitening composition containing mannosylerythritol lipid

Examples

Experimental program
Comparison scheme
Effect test

experiment Embodiment 1

[0042] Experimental Example 1: Confirmation of Whitening Effect

[0043] The inhibitory effect of mannose erythritol lipid (hereinafter referred to as MEL) on melanin production in melanogenic cells was measured. Cell Lines and Sera The mouse-derived B16F10 (melanoma cell) cell line and FBS (Cat. No. 30-2020) purchased from ATCC were used. DMEM (Cat. No. 11995) and antibiotic-antimycotic (Cat. No. 15240-062) required for cell culture were purchased from Invitrogen (GIBCO). at 37°C, 10% CO 2 Cell lines were cultured under conditions. The cultured B16F10 cells were removed with 0.05% trypsin-EDTA, and the same number (1×10 4 cells / well) were inoculated into a 48-well plate, and for three consecutive days from the second day, the medium containing α-MSH (200 mM) was replaced with phenol-free DMEM medium, and the phenol-free DMEM medium was added with 1 or 5 ppm MEL treatment. Kojic acid was used as a positive control. After the 5th day, 1N NaOH was added and reacted at 60° ...

experiment Embodiment 2

[0045] Experimental Example 2: Confirmation of Compatibility with Solvents

[0046] 1% of MEL was added to the main ingredients commonly used in common cosmetic formulations and stirred, and then visually observed whether there was precipitation or separation over time at room temperature, and it was shown in Table 1 below.

[0047] Table 1:

[0048] compatibility water △ 1,3-BG ○ Eutanol-G ○ CEH ○ CSA ○

[0049] (○: transparent solution, △: opaque solution, X: separation or precipitation)

[0050] In Table 1, 1,3-BG is 1,3-butanediol, Eutanol-G is octyldodecanol, CEH is cetyl ethyl acetate, and CSA is caprylic-capric triglyceride ester.

experiment Embodiment 3

[0051] Experimental Example 3: Confirmation of Odor Improvement of Hydrogenated MEL Raw Materials

[0052] MEL and hydrogenated MEL were dissolved in a suitable solvent at a concentration of 0.5%, and the odor at room temperature, the off-flavor caused by heating in a water bath for 3 hours, and the off-flavor under sunlight storage conditions were evaluated sensorily, and it was confirmed that the off-flavor of MEL was improved by hydrogenation , as shown in Table 2 below.

[0053] Table 2:

[0054] Room temperature heating Sunlight MEL ○ △ △ Hydrogenated MEL ○ ○ ○

[0055] (○: Good, △: Slight odor or change in taste, X: Severe odor or change in taste)

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Abstract

The present invention relates to a skin whitening composition containing mannosylerythritol lipid (MEL) as an active ingredient. The skin whitening composition according to the present invention suppresses the formation of skin melanocytes and improves the overall skin tone, and thus gives effectiveness of exhibiting clean, darkness-relieved, and bright skin. In addition, the composition can be easily formulated, and thus can be utilized in a high content for various dosage forms even without using a particular additional ingredient for formulating effective ingredient.

Description

technical field [0001] This application claims priority based on Korean Patent Application No. 10-2016-0115380 filed on September 8, 2016, the entire contents of which are incorporated herein by reference. [0002] The present invention relates to a skin whitening composition containing mannose erythritol lipid (MEL) as an active ingredient. Background technique [0003] The skin has physical and chemical UV protection factors and mechanisms to minimize skin damage caused by various photochemical reactions. The stratum corneum of the skin attenuates the energy of ultraviolet rays by reflecting and diffusing them, and melanin, superoxide dismutase (SOD), other antioxidant components, and the like absorb ultraviolet rays penetrating the inside of the skin and attenuate the energy of the ultraviolet rays or by removing Active oxygen generated secondary to ultraviolet rays protects the skin from damage. [0004] However, various skin damages occur when the body receives a larg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61K8/02A61Q19/02
CPCA61K8/60A61Q19/02A61K8/99A61K8/02A61K8/042A61K8/602
Inventor 俞载元黄允均宾圣娥金容震李存桓
Owner AMOREPACIFIC CORP
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