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Graphene oxide composite hydroxyapatite-loaded sulfur quantum dot antibacterial coating and preparation method thereof

A composite hydroxyapatite and antibacterial coating technology, applied in coatings, antifouling/underwater coatings, paints containing biocides, etc. , to quickly and effectively kill bacteria, the preparation method is simple and easy, and the effect of increasing the production of active oxygen

Active Publication Date: 2021-09-03
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the widespread use of implant materials, the bacterial infection caused by the implant is a big problem. Once the implant is infected, the antibacterial means in the body are very limited, and the bacterial infection caused is difficult to remove. It will cause great pain and economic loss to patients, and even cause amputation or death

Method used

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  • Graphene oxide composite hydroxyapatite-loaded sulfur quantum dot antibacterial coating and preparation method thereof
  • Graphene oxide composite hydroxyapatite-loaded sulfur quantum dot antibacterial coating and preparation method thereof
  • Graphene oxide composite hydroxyapatite-loaded sulfur quantum dot antibacterial coating and preparation method thereof

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preparation example Construction

[0039] Also provided is a preparation method of graphene oxide composite hydroxyapatite-loaded sulfur quantum dot antibacterial coating, comprising the following steps:

[0040] S1. Pretreatment of titanium sheets: Polish the titanium sheets with 240, 400, 600, 800 and 1200 mesh sandpaper in sequence, then ultrasonically clean them with water and ethanol, and then put the titanium sheets into a mixed solution of concentrated sulfuric acid, concentrated hydrochloric acid and water In the process, after heating and reacting in a polytetrafluoroethylene reactor, it is taken out and cleaned, and then calcined in a muffle furnace;

[0041] S2. Preparation of graphene oxide composite hydroxyapatite coating: Add disodium edetate powder to calcium nitrate solution, mix evenly to obtain mixed solution A, mix mixed solution A with diammonium hydrogen phosphate solution in the same volume, Adjust the pH to 8.7-10.5, add the graphene oxide solution, stir well to obtain the mixed solution ...

Embodiment 1

[0051] (1) Pretreatment of titanium sheets: First, polish the titanium sheets with 240, 400, 600, 800, and 1200 mesh sandpaper, then ultrasonically clean them with water and ethanol, and add concentrated sulfuric acid to the titanium sheets: Concentrated hydrochloric acid: The mass ratio of water In a mixed solution of 1:1:1, react in a polytetrafluoroethylene reactor at 60°C for 1.5h, take out the titanium sheet for cleaning, and then calcinate in a muffle furnace at 650°C for 1h to obtain a pretreated titanium sheet.

[0052] (2) Preparation of graphene oxide composite hydroxyapatite coating: add 2g of disodium edetate powder to 30mL of 0.2mol / L calcium nitrate solution, mix evenly to obtain mixed solution A, and then configure 0.12mol / L L of diammonium hydrogen phosphate solution, mix 30mL of mixed solution A with 30mL of diammonium hydrogen phosphate solution in the same volume, adjust the pH to 10.5, add 2mg / mL graphene oxide 10mL, after fully stirring, and step (1) The o...

Embodiment 2

[0056] (1) Pretreatment of titanium sheets: First, polish the titanium sheets with 240, 400, 600, 800, and 1200 mesh sandpaper, then ultrasonically clean them with water and ethanol, and add concentrated sulfuric acid to the titanium sheets: Concentrated hydrochloric acid: The mass ratio of water In a mixed solution of 1:1:1, react in a polytetrafluoroethylene reactor at 70°C for 1 hour, take out the titanium sheet for cleaning, and then calcinate it in a muffle furnace at 600°C for 1.5 hours to obtain a pretreated titanium sheet.

[0057] (2) Preparation of graphene oxide composite hydroxyapatite coating: add 2g of disodium edetate powder to 30mL of 0.2mol / L calcium nitrate solution, mix evenly to obtain mixed solution A, and then configure 0.12mol / L L of diammonium hydrogen phosphate solution, mix 30mL of mixed solution A with 30mL of diammonium hydrogen phosphate solution in the same volume, adjust the pH to 9.5, add 1mg / mL graphene oxide 10mL, after fully stirring, and step...

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Abstract

The invention discloses a graphene oxide composite hydroxyapatite-loaded sulfur quantum dot antibacterial coating, which includes a substrate, the substrate is covered with a composite coating, and the composite coating is graphene oxide composite hydroxyapatite And loaded with sulfur quantum dots. The preparation method includes: S1, pretreatment of the substrate; S2, preparation of graphene oxide composite hydroxyapatite coating; S3, preparation of sulfur quantum dot solution; S4, loading of sulfur quantum dots in a vacuum environment to obtain antibacterial performance composite coating. The coating provided by the invention is easy to prepare, has excellent antibacterial properties, does not cause bacteria to develop drug resistance, and has good biocompatibility, and can be applied to medical implant materials.

Description

technical field [0001] The invention relates to the field of material science and nanomaterial technology, in particular to a graphene oxide composite hydroxyapatite-loaded sulfur quantum dot antibacterial coating that can be excited by near-infrared light and a preparation method thereof. Background technique [0002] Biomedical implant materials are the basis for the study of artificial organs and medical devices. Medical titanium metal has excellent corrosion resistance, elastic modulus close to natural bone, and good biocompatibility. It is often used to manufacture medical devices, prostheses or Artificial organs and artificial bones. However, with the widespread use of implant materials, the bacterial infection caused by the implant is a big problem. Once the implant is infected, the antibacterial means in the body are very limited, and the bacterial infection caused is difficult to remove. It will cause great pain and economic loss to the patient, and even cause ampu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D1/00C09D5/14
Inventor 吴水林徐小默刘想梅
Owner HUBEI UNIV
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