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Meningeal or spinal meningeal biological membrane prepared by collagen materials and preparation method of meningeal or spinal meningeal biological membrane

A collagen material and biofilm technology, applied in medical science, prosthesis, etc., can solve problems such as low collagen content, impact, and poor mechanical properties

Inactive Publication Date: 2019-05-24
南杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of collagen fibers in weak acids (such as acetic acid) is limited, resulting in poor mechanical properties of the final dura (spinal) membrane product due to its low collagen content, and the ability to prevent body fluid leakage is also affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] Take the self-made collagen fiber plate and cut it into collagen pieces of 2.5mm×2.5mm by machine at room temperature. Put the collagen into a grinder at an ambient temperature of 4°C, and grind it into powder at a speed of 10,000 rpm. Use 80-mesh and 100-mesh metal sieves to obtain collagen powder with a pore size of 80-100 mesh. Weigh 1g of collagen powder at room temperature, add it to 100ml of acetic acid solution, adjust the pH to 4.2, and make a 1% collagen solution, stir with a stirrer at a low speed until swelling, and continue to stand for several hours to form a solution. Pour the collagen solution into a homogenizer, homogenize intermittently (the machine works for 1 minute, and rests for 1 minute), for a total of 15 minutes to obtain a uniform collagen solution, and remove air bubbles by vacuum filtration. A hollow circular plastic tube (inner diameter 5cm, height 5cm) is open at both ends, a 100-mesh metal screen is embedded in one end as the bottom of the...

example 2

[0018] Commercially available flocculent collagen fibers were taken and machine-cut into 5 mm long collagen strips at room temperature. The collagen strips were put into a grinder at 4°C ambient temperature at 8000 rpm to grind into powder. Sieve the collagen powder with 80-100 mesh aperture size with 80 mesh and 100 mesh metal sieves. Weigh 5g of collagen powder at room temperature, add it to 1000ml of acetic acid solution, adjust the pH to 4.0, and make a 0.5% collagen solution, stir with a stirrer at a low speed until swelling, and continue to stand for several hours to form a solution. Pour the collagen solution into a homogenizer, homogenize intermittently (the machine works for 1 minute, and rests for 1 minute), for a total of 20 minutes to obtain a uniform collagen solution, and remove air bubbles by vacuum filtration. A hollow circular plastic tube (inner diameter 12cm, height 5cm) is open at both ends, a 100-mesh metal screen is embedded in one end as the bottom of t...

example 3

[0020] Take the self-made collagen fiber plate and cut it into 5mm long collagen pieces at room temperature. The collagen strips were put into a grinder at 4°C ambient temperature at 8000 rpm to grind into powder. Sieve the collagen powder with 80-100 mesh aperture size with 80 mesh and 100 mesh metal sieves. Weigh 2g of collagen powder at room temperature, add it to 400ml of acetic acid solution, adjust the pH to 3.8, and make a 0.5% collagen solution, stir with a stirrer at low speed until swelling, and continue to stand for several hours to form a solution. Pour the collagen solution into a homogenizer, homogenize intermittently (the machine works for 1 minute, and rests for 1 minute), for a total of 15 minutes to obtain a uniform collagen solution, and remove air bubbles by vacuum filtration. A hollow square plastic tube (diameter 8cm×8cm, height 10cm) with two ends open, a 100-mesh metal screen is embedded in one end as the bottom of the container for placing the collage...

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PUM

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Abstract

The invention relates to a meningeal or spinal meningeal biological membrane prepared by collagen materials and a preparation method of the meningeal or spinal meningeal biological membrane, belongs to the field of biological medical materials, and mainly aims to solve the problems that currently a prepared collagen solution is low in concentration due to the fact that collagen is poor in solubility under a weak acid condition, and a collagen artificial cerebral dura mater (spinal dura mater) prepared by the collagen solution is poor in mechanical performance and body fluid leakage preventionperformance.

Description

technical field [0001] The invention relates to a meningeal or meningeal biofilm prepared from collagen materials and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] The human brain and spinal cord are covered with meninges, which are divided into three layers: dura mater, arachnoid mater and pia mater from outside to inside, which are crucial to maintaining the normal function of the central nervous system. Biocompatible and biodegradable artificial dura (spinal) membranes are often used to restore the integrity and functionality of damaged brain (spinal) membranes caused by diseases and trauma. Collagen has been used clinically as an artificial dura (spinal) membrane. At present, the technological process of artificial dura (spine) membrane with collagen as matrix generally involves the preparation and freezing of collagen solution. In order to be close to the neutral acid-base environment of the brain (spinal) ...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/50
Inventor 南杰
Owner 南杰
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