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Detection method of diazepam in fresh water

A detection method, the technology of diazepam, is applied in the field of detection of water environmental pollutants, which can solve problems such as residues, water body impact, and damage to people who eat it, and achieve accurate judgment, good stability, enrichment efficiency, and good purification effect Effect

Inactive Publication Date: 2019-05-17
山东省海洋资源与环境研究院
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Problems solved by technology

[0003] However, in addition to diazepam remaining in farmed animals and aquatic products and causing damage to the people who eat it, because aquatic products inevitably need to come into contact with water bodies when feeding medicines, it will inevitably cause damage to water bodies. Once the water body is affected and polluted, the surrounding soil and growing crops will also be affected by drinking and irrigation of the water body, so sufficient attention should be paid to the detection of diazepam in the water body

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  • Detection method of diazepam in fresh water
  • Detection method of diazepam in fresh water
  • Detection method of diazepam in fresh water

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Embodiment Construction

[0044] Hereinafter, the present invention will be further described through embodiments in conjunction with the drawings.

[0045] The specific implementation examples of the method for detecting diazepam in freshwater of the present invention are as follows:

[0046] (1) Reagents and materials

[0047] a) Ultra-pure water

[0048] b) Methanol: chromatographically pure

[0049] c) Acetonitrile: chromatographically pure

[0050] d) Formic acid: chromatographically pure

[0051] e) MCX column: 60mg, 3mL.

[0052] f) 0.45μm cellulose acetate filter membrane

[0053] g) 0.22μm PVDF filter membrane

[0054] h) 0.2mol / L hydrochloric acid: Take 10mL premium grade pure concentrated hydrochloric acid and add it to 490mL ultrapure water.

[0055] i) 5% ammonia water methanol: Take 25mL superior grade pure ammonia water and add it to 475mL methanol.

[0056] j) Fixed solution: formic acid, acetonitrile and water are prepared in a volume ratio of 0.01:7:3.

[0057] k) 100mg / L diazepam standard stock soluti...

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Abstract

The invention relates to a detection method of diazepam in fresh water and belongs to the technical field of water environment pollutant detection. After a detecting water sample is filtered by a filter membrane, hydrochloric acid is added, the detecting water sample is treated through an MCX small column, the enrichment efficiency of the diazepam has obvious advantages, the enrichment efficiencyand the purification effect are better, the lower detection limit and better stability can be achieved, the detection limit of the diazepam can reach 0.5 ng / L, thus the content of the diazepam in a water body can be detected rapidly and effectively, the pollution situation of the water body environment is judged accurately, and risk early-warning is conveniently established in advance.

Description

Technical field [0001] The invention relates to a method for detecting diazepam in fresh water, and belongs to the technical field of water environment pollutant detection. Background technique [0002] Diazepam, also known as Valium, is a central nervous system sedative, its chemical name is 1-methyl-5-phenyl-7chloro-1,3-dihydro-2H-1,4-benzodiazepine -2-2 Ketone is mainly used for the treatment of sedation, hypnosis and epilepsy in humans and animals. The metabolism of diazepam is mainly carried out in the liver. In recent years, criminals have illegally used diazepam during the feeding, fishing, and transportation of aquatic animals without authorization, resulting in residues of diazepam in aquatic products. After diazepam’s residual aquatic products, the burden on the liver will increase, the mind will be dizzy, memory impairment, and severe skin rashes, leukopenia, and motor nerve and muscle function will be inhibited. For this reason, the Ministry of Agriculture issued a n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/08
Inventor 徐英江任传博田秀慧韩典峰薛敬林张华威罗晶晶黄会
Owner 山东省海洋资源与环境研究院
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