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Application of homoharringtonine in preparing medicine for preventing foot-and-mouth virus infection

A technology of homoharringtonine and foot-and-mouth disease virus, which is applied in the direction of antiviral agents, active ingredients of heterocyclic compounds, etc., and can solve problems such as inability to provide protection for animals

Inactive Publication Date: 2019-05-14
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, vaccine immunization is the main means of preventing and controlling foot-and-mouth disease. However, there is an "immunity window period" in the use of vaccines, that is, it cannot provide protection to animals within 7 days.

Method used

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  • Application of homoharringtonine in preparing medicine for preventing foot-and-mouth virus infection
  • Application of homoharringtonine in preparing medicine for preventing foot-and-mouth virus infection
  • Application of homoharringtonine in preparing medicine for preventing foot-and-mouth virus infection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Experimental materials

[0022] 1.1 Cells, viruses and drugs

[0023] IBRS-2 cells were preserved by our research group; FMDV (O / MY98 / BY / 2010 and A / GDMM / CHA / 2013) were preserved and provided by the National Foot-and-Mouth Disease Reference Laboratory; Homoharringtonine was purchased from MCE Company and prepared with DMSO.

[0024] 1.2 Reagents

[0025] DMEM, fetal bovine serum FBS, and trypsin medium were purchased from Gibco; MTS detection kits were purchased from Abcam; TRIZOL was purchased from Invitrogen; SYBR Premix Ex TaqⅡ kits were purchased from Treasure Bioengineering (Dalian) Co., Ltd.; RIPA The lysate, BCA protein quantification kit, SDS-PAGE gel preparation kit, and ECL were purchased from Beyontian; BSA and PVDF membranes were purchased from BioRad; Tween-20 was purchased from Shanghai Sangon Bioengineering Company; Triton X -100. DMSO was purchased from Sigma Company; mouse anti-β-actin polyclonal antibody, HRP-labeled anti-rabbit or anti-mouse IgG a...

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Abstract

The invention relates to application of homoharringtonine in preparing medicine for preventing foot-and-mouth disease virus infection, and belongs to the technical field of veterinary medicine. By means of the application, highly effective, safe and quality-controllable anti-foot-and-mouth disease virus medicine can be provided for further controlling spread of a foot-and-mouth disease.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to the application of homoharringtonine in the preparation of drugs for preventing foot-and-mouth disease virus infection. Background technique [0002] Foot-and-mouth disease virus is a non-enveloped single-stranded positive-sense RNA virus belonging to the Picornaviridae family. It has been found that the virus includes 7 serotypes including A, O, C, Asian I, and South African I, II, and III, and each serotype is divided into multiple subtypes. The foot-and-mouth disease caused by this virus mainly infects cloven-hoofed animals such as pigs and cattle, and often forms blisters in the mouth, nose, hooves and other parts, accompanied by clinical symptoms such as fever and walking. Foot-and-mouth disease has many transmission routes, wide epidemic range and strong infectivity. Currently, frequent outbreaks in many countries have seriously threatened the development of globa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61P31/14
Inventor 龚美娇常惠芸李世芳邵军军常艳燕张永光
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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