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Highly anti-coagulant polystyrene microsphere and preparation and application methods thereof

A polystyrene microsphere, high-resistance technology, used in the preparation of microspheres, microcapsule preparations, chemical instruments and methods, etc., can solve problems such as poor blood coagulation, achieve excellent blood compatibility, strong anticoagulation performance, Easy to operate and achieve effects

Active Publication Date: 2019-05-10
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all kinds of polystyrene microsphere adsorbents currently in clinical use on the market or newly developed by researchers all have a common deficiency. They are prone to poor coagulation during use, which leads to anemia in patients after multiple hemodialysis. Even sepsis and other induced diseases
For the anticoagulant modification of polystyrene microspheres for blood purification, there are few reports on effective technical means at present.

Method used

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  • Highly anti-coagulant polystyrene microsphere and preparation and application methods thereof
  • Highly anti-coagulant polystyrene microsphere and preparation and application methods thereof
  • Highly anti-coagulant polystyrene microsphere and preparation and application methods thereof

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preparation example Construction

[0030] Another aspect of the embodiments of the present invention also provides a method for preparing high anticoagulation polystyrene microspheres, which includes:

[0031] In a protective atmosphere, the homogeneously mixed reaction system comprising alkene acid monomers, sodium sulfonate monomers, crosslinking agent monomers, initiators and water is polymerized and crosslinked at 50-100°C for 4-24 hours to obtain Active heparin aqueous solution;

[0032] The polystyrene microsphere body is contacted with the active heparin aqueous solution, and then the obtained polystyrene microsphere is placed in an acidic condition and heated at 45-80°C for 6-24 hours to obtain high anticoagulation through self-polymerization and cross-linking type polystyrene microspheres.

[0033] In some preferred embodiments, the preparation method specifically includes: adding alkenoic acid monomers, sodium sulfonate monomers, and crosslinking agent monomers to deionized water, and then stirring i...

Embodiment example

[0035] Wherein, as a more preferred embodiment of the present invention, the preparation method includes the following steps:

[0036] S1: Add a certain amount of alkene acid monomers, sodium sulfonate monomers, and crosslinking agent monomers to 100 parts by mass of deionized water, and then stir for no less than 30 minutes in a nitrogen or argon atmosphere to eliminate oxygen;

[0037] S2: Add a certain amount of initiator, keep stirring in nitrogen or argon atmosphere, and raise the temperature to 50-100°C, and react for 4-24 hours to obtain an aqueous solution of active heparin;

[0038] S3: After the obtained active heparin aqueous solution is cooled to room temperature, a quantitative amount of polystyrene microspheres is added to the solution and soaked for 0.15-2 hours;

[0039] S4, transfer the polystyrene microspheres into an acidic aqueous solution with a pH value of 0-4, heat at 45-80°C for 6-24 hours, then wash with deionization and then dry to obtain the high an...

Embodiment 1

[0061] Step (1) Add 100g of deionized water into a three-necked flask, then add 3g of acrylic acid, 4g of sodium p-styrene sulfonate and 5g of N-methylolacrylamide, and then stir for 40min under a nitrogen atmosphere at 250 rpm , to get rid of the oxygen in the reaction solution;

[0062] Step (2) Add 0.2 g of azobisisobutylamidine hydrochloride, keep stirring in a nitrogen atmosphere, and raise the temperature to 80° C., and react for 10 hours to obtain an aqueous solution of active heparin;

[0063] Step (3) Weigh 20 g of polystyrene microspheres (commercially purchased product described in Comparative Example 1), and ultrasonically clean them with 20% ethanol / deionized solution for 20 minutes. Then, after the heparinoid aqueous solution obtained in step (2) is cooled to room temperature, the washed polystyrene microspheres are added to the solution and soaked for 1 hour;

[0064] Step (4) Transfer the polystyrene microspheres to an acidic aqueous solution with a pH value o...

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Abstract

The invention discloses a highly anti-coagulant polystyrene microsphere and preparation and application methods thereof. The highly anti-coagulant polystyrene microsphere comprises a polystyrene microsphere body and an anti-coagulant modification layer formed on the surface of the polystyrene microsphere body, wherein the anti-coagulant modification layer comprises a heparinoid functional layer, and the heparinoid function layer comprises an active heparinoid polymer prepared by polymerizing and crosslinking olefin acid monomers, sodium sulfonate monomers and crosslinking agent monomers. The preparation method of the highly anti-coagulant polystyrene microsphere comprises subjecting the olefin acid monomers, the sodium sulfonate monomers, the crosslinking agent monomers and initiators to polymerization and crosslinking reaction to obtain an active heparinoid aqueous solution, subjecting the polystyrene microsphere body to contact with the active heparinoid aqueous solution and then auto-polymerization and crosslinking under acid conditions to obtain the highly anti-coagulant polystyrene microsphere. The prepared highly anti-coagulant polystyrene microsphere is high in blood compatibility, and meanwhile, the preparation method of the highly anti-coagulant polystyrene microsphere is simple in technical process, easy to operate and implement and applicable to industrial productionand popularization.

Description

technical field [0001] The invention belongs to the field of blood purification, and in particular relates to an anticoagulation modification method of a blood toxin adsorbent, in particular to a high anticoagulation polystyrene microsphere, a preparation method thereof, and an application thereof in blood purification. Background technique [0002] Blood purification is currently the core treatment method for patients with kidney disease (especially uremia) to maintain life, and it is also one of the important treatment methods in the fields of poisoning first aid, liver disease and critical illness. At present, the means of blood purification are mainly membrane separation and adsorption separation. Among them, membrane separation can efficiently remove small-molecule toxins in blood, but its ability to remove middle-molecule microglobulins (such as β-microglobulin), pathogenic factors, and interleukins in blood is very limited. Adsorption separation technology must be us...

Claims

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Application Information

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IPC IPC(8): C08F220/58C08F212/14C08F220/06C08F228/02C08J7/12B01J13/14A61M1/16A61M1/36C08L33/24C08L5/08B01J20/26B01J20/28B01J20/30
Inventor 林海波刘富韩秋柳杨
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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